Abstract: Provided is an antibody-tumor necrosis factor ? fusion protein and its preparation and applications. Specifically, the present disclosure relates to a fusion protein comprising an antibody moiety and a TNF? moiety, a nucleic acid molecule encoding same, a nucleic acid construct, a host cell and a method of production thereof, as well as applications of these materials in prevention and/or treatment of tumors.

Abstract: Provided are a fusion protein, a preparation method therefor and use thereof. The protein can: (a) inhibit TNFa-induced apoptosis; and/or (b) inhibit TRAIL-induced apoptosis; and/or (c) inhibit differentiation of RANKL-induced mononuclear macrophages. The protein is capable of (i) preventing and/or treating infectious diseases; and/or (ii) preventing and/or treating autoimmune diseases; and/or (iii) preventing and/or treating osteoporosis or loss; and/or (iv) preventing and/or treating tumor-associated diseases.

Abstract: Provided is an antibody-tumor necrosis factor ? fusion protein and its preparation and applications. Specifically, the present disclosure relates to a fusion protein comprising an antibody moiety and a TNF? moiety, a nucleic acid molecule encoding same, a nucleic acid construct, a host cell and a method of production thereof, as well as applications of these materials in prevention and/or treatment of tumors.