Patents by Inventor Bang Luu
Bang Luu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120136068Abstract: The present invention relates to an agent for improving renal dysfunction comprising as an active ingredient a compound represented by the following formula (1): wherein each R1, R2, and R3 represents a hydrogen atom or a methyl group, and X represents a linear or branched alkylene or alkenylene group having 10 to 28 carbon atoms.Type: ApplicationFiled: February 7, 2012Publication date: May 31, 2012Applicant: MEIJI CO., LTD.Inventors: Keisuke Sato, Motoaki Saito, Bang Luu, Masashi Yamada, Hiroto Suzuki
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Patent number: 7902249Abstract: Provided is an indole long-chain alcohol, or a hydrate or an isomer thereof, represented by the following formula (I): wherein R1, R2, R3 and R4 each independently represent a hydrogen atom, a methyl group, an acetyl group, or a hydroxyl group, and n represents a number from 0 to 20; and a medicinal composition comprising the same. The indole long-chain alcohol (I) exhibits an excellent nerve growth promoting effect, as well as potent antioxidative and anti-tumor effects, and is therefore useful as a prophylactic and/or therapeutic agent for cerebral diseases including dementia diseases, and malignant tumors including brain tumors.Type: GrantFiled: June 3, 2008Date of Patent: March 8, 2011Assignee: Meiji Dairies CorporationInventors: Bang Luu, Djalil Coowar, Masashi Yamada, Yukie Suma, Hiroto Suzuki
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Patent number: 7893304Abstract: The present invention provides compounds that are useful for preventing or treating brain dysfunctions, motor dysfunctions, or urinary dysfunctions caused by the degeneration and/or loss of the central nervous system or peripheral nervous system cells.Type: GrantFiled: February 23, 2006Date of Patent: February 22, 2011Assignee: Meiji Dairies CorporationInventors: Bang Luu, Dominique Bagnard, Mazen Hanbali, Masashi Yamada, Hiroto Suzuki
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Patent number: 7888395Abstract: The present invention relates to an agent for suppressing STAT3 phosphorylation and for suppressing Notch1 expression comprising as an active ingredient a compound represented by the following formula (1): wherein R1, R2 and R3 each independently represents a hydrogen atom or a methyl group; and X represents a linear or branched alkyl, alkylene or alkenylene group having 10 to 28 carbon atoms.Type: GrantFiled: October 13, 2005Date of Patent: February 15, 2011Assignee: Meiji Dairies CorporationInventors: Bang Luu, Ellane Mohier, Masashi Yamada, Hiroto Suzuki
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Patent number: 7838565Abstract: A preventive and/or therapeutic agent for diabetes complications, which comprises as an effective ingredient a cyclohexenone long-chain alcoholic derivative represented by the following formula (1): wherein, R1, R2 and R3 each independently represents a hydrogen atom or a methyl group and X represents a linear or branched C10-28 alkylene or alkenylene group. The cyclohexenone long-chain alcoholic derivative of the present invention significantly suppresses a reduction in a peripheral nerve conduction rate and alleviates the hypofunction of the bladder so that it is useful as a preventive and/or therapeutic agent for diabetes complications, particularly, for diabetic neuropathy.Type: GrantFiled: February 15, 2002Date of Patent: November 23, 2010Assignee: Meiji Dairies CorporationInventors: Masao Miyagawa, Takeshi Watanabe, Motoaki Saito, Bang Luu, Masashi Yamada, Hiroto Suzuki
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Publication number: 20100094061Abstract: The present invention relates to an agent for suppressing STATS phosphorylation and for suppressing Notch1 expression comprising as an active ingredient a compound represented by the following formula (1): wherein R1, R2 and R3 each independently represents a hydrogen atom or a methyl group; and X represents a linear or branched alkyl, alkylene or alkenylene group having 10 to 28 carbon atoms.Type: ApplicationFiled: October 13, 2005Publication date: April 15, 2010Applicant: Meiji Dairies CorporationInventors: Bang Luu, Ellane Mohier, Masashi Yamada, Hiroto Suzuki
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Patent number: 7691900Abstract: The invention relates to any isolated or synthetic compound and, in particular, to compounds having formula which can: modulate the cell specification of neural stem cells, promote the differentiation and subsequent survival of differentiating glial cells and neurones, and promote the differentiation of oligodendrocyte precursor cells into mature oligodendrocytes. In addition, the inventive compounds can reduce the inflammatory component of diseases that affect the nervous system, for example, by reducing activation of the microglia an/or astrocytes and/or by reducing reactive gliosis. The invention also relates to the methods of preparing such compounds and to the use of same in the preparation of a pharmaceutical composition that is intended for the prevention or treatment of diseases that affect the nervous system. More specifically, the inventive compounds have general formula.Type: GrantFiled: September 24, 2004Date of Patent: April 6, 2010Assignee: AxoGlia Therapeutics S.A.Inventors: Bang Luu, Paul Heuschling, Thierry Muller, Eleonora Morga
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Publication number: 20100048731Abstract: The present invention relates to a compound of general formula (I) below in which R1, R2 and R3 represent, independently of one another, a hydrogen atom or a C1-C6 alkyl group or a (C1-C6 alkyl)carbonyl group, R4, R5, R6 and R7 represent a hydrogen or a C1-C6 alkyl group, a C1-C6 alkoxy group or a (C1-C6 alkyl)carbonyloxy group, and n is an integer between 8 and 20, or its pharmaceutically acceptable addition salts, isomers, enantiomers and diastereoisomers, and also mixtures thereof. The invention also relates to a pharmaceutical composition comprising the compound and to the use thereof as a neurotrophic agent.Type: ApplicationFiled: March 2, 2007Publication date: February 25, 2010Applicants: Centre National de la Recherche Scientifique(CNRS), Universite de LuxembourgInventors: Bang Luu, Frédérique Hauss, Djalil Coowar, Jiawei Liu, Paul Heuschling, Eleonora Morga, Luc Grandbarbe, Alessandro Michelucci
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Publication number: 20090069442Abstract: The present invention provides therapeutic agents for sensory disorders represented by the following formula (1): [wherein R1, R2, and R3 each represent a hydrogen atom or a methyl group, and X represents a linear or branched C10-C28 alkylene or alkenylene group]. The cyclohexenone long chain alcohol of the present invention improves hyperalgesia or hypoalgesia, and thus is useful as therapeutic agents for sensory disorders. Sensory disorders that can be prevented or treated by the present invention include chronic intractable pain, neurogenic pain, reduction of pain threshold caused by nerve injuries, hypesthesia or hyperesthesia caused by diabetes and nerve injuries, and the like.Type: ApplicationFiled: January 18, 2006Publication date: March 12, 2009Inventors: Hirohito Shiomi, Yutaka Tamura, Bang Luu, Masashi Yamada, Keizou Koyama, Hiroto Suzuki
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Publication number: 20090036542Abstract: The present invention provides compounds represented by formula (1) shown below: (wherein R1, R2, R3, R4, and R5 are each individually selected from among a hydrogen atom, methyl group, acetyl group, hydroxyl group, and alkoxy group; and X represents an alkylene group or alkenylene group); and compounds represented by formula (2) shown below: (wherein R6, R7, R8, R9, and R10 are each individually selected from among a hydrogen atom, alkyl group, acetyl group, hydroxyl group, and alkoxy group; A represents an oxygen atom or NH, and m is 0 or 1; and Y represents an alkylene group or alkenylene group, and Z represents a hydrogen atom or hydroxyl group). The compounds of the present invention are useful for preventing or treating brain dysfunctions, motor dysfunctions, or urinary dysfunctions caused by the degeneration and/or loss of the central nervous system or peripheral nervous system cells.Type: ApplicationFiled: February 23, 2006Publication date: February 5, 2009Inventors: Bang Luu, Dominique Bagnard, Mazen Hanbali, Masashi Yamada, Hiroto Suzuki
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Publication number: 20080312336Abstract: The present invention provides preventive and/or therapeutic agents for either one, or both, of a diabetic vascular disorder and a diabetic respiratory disorder comprising, as an active ingredient, a cyclohexenone long chain alcohol compound represented by the following formula (1): [wherein R1, R2, and R3 each represent a hydrogen atom or a methyl group, and X represents a linear or branched C10-C28 alkylene or alkenylene group]. Since the cyclohexenone long chain alcohol of formula (1) improves diabetic vascular smooth muscle contraction and bronchial smooth muscle contraction, it is useful as a preventive and/or therapeutic agent for a diabetic vascular disorder or a respiratory disorder.Type: ApplicationFiled: November 24, 2005Publication date: December 18, 2008Inventors: Keisuke Satoh, Motoaki Saito, Bang Luu, Masashi Yamada, Hiroto Suzuki
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Publication number: 20080234357Abstract: Provided is an indole long-chain alcohol, or a hydrate or an isomer thereof, represented by the following formula (I): wherein R1, R2, R3 and R4 each independently represent a hydrogen atom, a methyl group, an acetyl group, or a hydroxyl group, and n represents a number from 0 to 20; and a medicinal composition comprising the same. The indole long-chain alcohol (I) exhibits an excellent nerve growth promoting effect, as well as potent antioxidative and anti-tumor effects, and is therefore useful as a prophylactic and/or therapeutic agent for cerebral diseases including dementia diseases, and malignant tumors including brain tumors.Type: ApplicationFiled: June 3, 2008Publication date: September 25, 2008Applicant: MEIJI DAIRIES CORPORATIONInventors: Bang LUU, Djalil Coowar, Masashi Yamada, Yukie Suma, Hiroto Suzuki
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Patent number: 7407983Abstract: Provided is an indole long-chain alcohol, or a hydrate or an isomer thereof, represented by the following formula (I): wherein R1, R2, R3 and R4 each independently represent a hydrogen atom, a methyl group, an acetyl group, or a hydroxyl group, and n represents a number from 0 to 20; and a medicinal composition comprising the same. The indole long-chain alcohol (I) exhibits an excellent nerve growth promoting effect, as well as potent antioxidative and anti-tumor effects, and is therefore useful as a prophylactic and/or therapeutic agent for cerebral diseases including dementia diseases, and malignant tumors including brain tumors.Type: GrantFiled: February 13, 2002Date of Patent: August 5, 2008Assignee: Meiji Dairies CorporationInventors: Bang Luu, Djalil Coowar, Masashi Yamada, Yukie Suma, Hiroto Suzuki
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Publication number: 20080125495Abstract: The present invention relates to an agent for improving renal dysfunction comprising as an active ingredient a compound represented by the following formula (1): wherein each R1, R2, and R3 represents a hydrogen atom or a methyl group, and X represents a linear or branched alkylene or alkenylene group having 10 to 28 carbon atoms.Type: ApplicationFiled: November 25, 2005Publication date: May 29, 2008Applicant: MEIJI DAIRIES CORPORATIONInventors: Keisuke Sato, Motoaki Saito, Bang Luu, Masashi Yamada, Hiroto Suzuki
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Patent number: 7307098Abstract: An indole derivative represented by the following general formula (1): wherein at least one of R1, R2, R3, and R4 represents an alkoxy group containing 1 to 20 carbon atoms, and other groups of the R1, R2, R3, and R4 represent hydrogen, an alkyl group containing 1 to 6 carbon atoms, acetyl group, or hydroxyl group; and either one of X and Y represents —(CH2)nOH wherein n is an integer of 0 to 30, and the other one of the X and Y represents hydrogen atom; or a salt thereof; and a drug and an agent for promoting differentiation of a stem cell containing such indole derivative or its salt as an effective component, wherein the indole derivative (1) has action of inducing differentiation of neural stem cell specifically into a neuron, and this indole derivative is useful as a prophylactic or therapeutic drug for brain dysfunction or neuropathy caused by loss or degeneration of the neuron.Type: GrantFiled: July 22, 2003Date of Patent: December 11, 2007Assignee: Meiji Dairies CorporationInventors: Bang Luu, Djalil Coowar, Ellane Mohier, Masashi Yamada, Yukie Suma, Hiroto Suzuki
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Patent number: 7235700Abstract: A process for producing cyclohexenone long-chain alcohol represented by the following formula (1): (wherein A represents a C10-C18 alkylene or alkenylene group, and each of R1, R2, and R3 individually represents hydrogen or methyl), comprising reacting a 3-alkoxy-2-cyclohexen-1-one derivative represented by the following formula (2): (wherein R1, R2, and R3 have the same meanings as above, and R4 represents a C1-C5 alkyl group) with a Grignard's reagent prepared by protecting the hydroxyl groups of C10-C18 ?-halogenoalcohol through silylation, and hydrolyzing the resultant reaction product.Type: GrantFiled: March 28, 2003Date of Patent: June 26, 2007Assignee: Meiji Dairies CorporationInventors: Bang Luu, Patrick Neuberg, Delphine Trancard, Masashi Yamada, Yukio Ohshiba, Hiroto Suzuki
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Publication number: 20070105946Abstract: The invention relates to any isolated or synthetic compound and, in particular, to compounds having formula which can: modulate the cell specification of neural stem cells, promote the differentiation and subsequent survival of differentiating glial cells and neurones, and promote the differentiation of oligodendrocyte precursor cells into mature oligodendrocytes. In addition, the inventive compounds can reduce the inflammatory component of diseases that affect the nervous system, for example, by reducing activation of the microglia an/or astrocytes and/or by reducing reactive gliosis. The invention also relates to the methods of preparing such compounds and to the use of same in the preparation of a pharmaceutical composition that is intended for the prevention or treatment of diseases that affect the nervous system. More specifically, the inventive compounds have general formula.Type: ApplicationFiled: September 24, 2004Publication date: May 10, 2007Applicants: UNIVERSITE LOUIS PASTEUR, CENTRAL NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DU LUXEMBOURGInventors: Bang Luu, Paul Heuschling, Thierry Muller, Eleonora Morga
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Patent number: 7166642Abstract: A preventive and therapeutic drug for a neurodegenerative disease containing, as an active ingredient, a cyclohexenone long-chain alcohol compound represented by formula (1) wherein each of R1, R2, and R3 represents a hydrogen atom or a methyl group; and X represents a C10–C28 alkylene group or alkenylene group. Since the compound of the present invention exhibits excellent neurite-extension ability and an inhibition effect on disorders caused by mutation in an SOD gene, it is useful as the active ingredient of a preventive and therapeutic drug for neurodegenerative diseases, inter alia, amyotrophic lateral sclerosis, and as the active ingredient of an inhibitory drug for disorders caused by mutation in an SOD gene.Type: GrantFiled: February 10, 2000Date of Patent: January 23, 2007Assignee: Meiji Dairies CorporationInventors: Bang Luu, Gaby Schmitt, Florence Keyling-Bilger, Celine Girlanda-Junges, Jean-Philippe Loeffler, Bernadette Lutz-Bucher, Jose-Luis Gonzalez de Aguilar, Masashi Yamada, Yukie Suma, Philippe Chabert
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Publication number: 20060135818Abstract: A process for producing cyclohexenone long-chain alcohol represented by the following formula (1): (wherein A represents a C10-C18 alkylene or alkenylene group, and each of R1, R2, and R3 individually represents hydrogen or methyl), comprising reacting a 3-alkoxy-2-cyclohexen-1-one derivative represented by the following formula (2): (wherein R1, R2, and R3 have the same meanings as above, and R4 represents a C1-C5 alkyl group) with a Grignard's reagent prepared by protecting the hydroxyl groups of C10-C18 ?-halogenoalcohol through silylation, and hydrolyzing the resultant reaction product. The process of the present invention for producing cyclohexenone long-chain alcohol requires a reduced number of reaction steps, can be performed with ease and with reduced production cost, and thus finds utility in the industry.Type: ApplicationFiled: March 28, 2003Publication date: June 22, 2006Inventors: Bang Luu, Patrick Neuberg, Delphine Trancard, Masashi Yamada, Yukio Ohshiba, Hiroto Suzuki
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Publication number: 20050261357Abstract: An indole derivative represented by the following general formula (1): wherein at least one of R1, R2, R3, and R4 represents an alkoxy group containing 1 to 20 carbon atoms, and other groups of the R1, R2, R3, and R4 represent hydrogen, an alkyl group containing 1 to 6 carbon atoms, acetyl group, or hydroxyl group; and either one of X and Y represents —(CH2)n OH wherein n is an integer of 0 to 30, and the other one of the X and Y represents hydrogen atom; or a salt thereof; and a drug and an agent for promoting differentiation of a stem cell containing such indole derivative or its salt as an effective component. The indole derivative (1) of the present invention has action of inducing differentiation of neural stem cell specifically into a neuron, and this indole derivative is useful as a prophylactic or therapeutic drug for brain dysfunction or neuropathy caused by loss or degeneration of the neuron.Type: ApplicationFiled: July 22, 2003Publication date: November 24, 2005Applicant: MEIJI DAIRIES CORPORATIONInventors: Bang Luu, Djalil Coowar, Ellane Mohier, Masashi Yamada, Yukie Suma, Hiroto Suzuki