Patents by Inventor Baoan Gao

Baoan Gao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210212947
    Abstract: The present invention relates to the technical field of medicine, which provides a liposomal docetaxel palmitate formulation and a method for preparing the said formulation. The liposomal docetaxel palmitate formulation contains docetaxel palmitate as the main drug, a chelating agent, lecithin and DSPE-PEG2000. It is characterized in that docetaxel is prepared into a docetaxel palmitate lipophilic prodrug, thus overcoming the defect that docetaxel cannot be processed into liposomes due to poor hydrophilicity and hydrophobicity. The liposome prescription of this invention contains a chelating agent with a substantive effect that can prolong the action time of the drug in the body, improve the anti-tumor effect and be prepared smoothly. Therefore, the chelating agent in the formulation is the core technical feature of the present invention.
    Type: Application
    Filed: April 26, 2019
    Publication date: July 15, 2021
    Inventors: Jianming CHEN, Baoan GAO, Youfa XU, Xin WU, Yamin SHI, Lang YAN, Zhiqin FU, Xiaoping LI
  • Publication number: 20190216768
    Abstract: The present invention relates to the field of medical technology. More specifically, the present invention relates to a preparation of taxanes for intravenous administration, which consists of two parts: a drug solution and an emulsion. Said drug solution consists of paclitaxel or docetaxel, a pH regulator and a solvent for injection, wherein said solvent for injection is an organic solvent. Said emulsion includes a fat emulsion and is composed of oil for injection, an emulsifier, an antioxidant, an isotonic regulator, a stabilizer, a pH regulator and water for injection. When used, the drug solution at the clinical dosage can be added and evenly mixed in the emulsion to perform intravenous drip directly; or the drug solution at the clinical dosage can also be firstly added into the emulsion with no less than 5 times volume of the drug solution and then a predetermined amount of normal saline or glucose solution for injection is added to perform intravenous drip.
    Type: Application
    Filed: March 21, 2019
    Publication date: July 18, 2019
    Applicant: JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD.
    Inventors: Jianming Chen, Baoan Gao, Jing Sun, Yue Zhang, Xiaoli Zheng, Ying Li, Dan Guo, Yang Zhang, Zhongbin Wu, Qiuxia Yang, Wei Liu, Peng Gu
  • Patent number: 10314923
    Abstract: A silybin injection contains silybin, sulfobutyl ether-?-cyclodextrin, an organic solvent for injection, a pH regulator, and may further contain a co-solvent, a lyophilization bulking agent, and water for injection.
    Type: Grant
    Filed: December 24, 2015
    Date of Patent: June 11, 2019
    Assignee: Tasly Pharmaceutical Group Co., Ltd.
    Inventors: Jianming Chen, Baoan Gao, Qinqin Zhou, Shuiping Zhou, Nan Cai, Yuansheng Zhang, Chan Wu, Nong Yu, Lina Chen, Wenli Liu
  • Publication number: 20180000965
    Abstract: A silybin injection contains silybin, sulfobutyl ether-?-cyclodextrin, an organic solvent for injection and may further contain a co-solvent, a lyophilization proppant, a pH regulator, water for injection and the like.
    Type: Application
    Filed: December 24, 2015
    Publication date: January 4, 2018
    Inventors: Jianming CHEN, Baoan GAO, Qinqin ZHOU, Shuiping ZHOU, Nan CAI, Yuansheng ZHANG, Chan WU, Nong YU, Lina CHEN, Wenli LIU
  • Publication number: 20170007570
    Abstract: The invention relates to a preparation of taxanes for intravenous administration consisting of a drug solution and an emulsion. The drug solution consists of paclitaxel or docetaxel, a pH regulator and an organic solvent for injection. The emulsion includes a fat emulsion and is composed of oil for injection, an emulsifier, an antioxidant, an isotonic regulator, a stabilizer, a pH regulator and water for injection. When used, the drug solution at the clinical dosage can be added and evenly mixed in the emulsion to perform intravenous drip directly; or the drug solution at the clinical dosage can also be firstly added into the emulsion with no less than 5 times volume of the drug solution and then a predetermined amount of normal saline or glucose solution for injection is added to perform intravenous drip. The preparation of the present invention does not contain solubilizer.
    Type: Application
    Filed: September 23, 2016
    Publication date: January 12, 2017
    Applicant: TASLY HOLDING GROUP CO., LTD.
    Inventors: Jianming Chen, Baoan Gao, Jing Sun, Yue Zhang, Xiaoli Zheng, Ying Li, Dan Guo, Yang Zhang, Zhongbin Wu, Qiuxia Yang, Wei Liu, Peng Gu
  • Patent number: 9241922
    Abstract: A pharmaceutical solution of taxanes, its preparation method, a composition comprising said solution and its pharmaceutical combination package are disclosed. Said pharmaceutical solution comprises taxanes, a pH regulator and a solvent, wherein the pH regulator is a water-soluble acid.
    Type: Grant
    Filed: October 22, 2010
    Date of Patent: January 26, 2016
    Assignee: Tasly Holding Group Co., Ltd.
    Inventors: Jianming Chen, Baoan Gao, Li Deng, Qiuxia Yang, Jing Sun, Wei Liu, Peng Gu, Yingying Zhang, Jialiang Zhang
  • Publication number: 20140045927
    Abstract: The present invention relates to the field of medical technology. More specifically, the present invention relates to a preparation of taxanes for intravenous administration, which consists of two parts: a drug solution and an emulsion. Said drug solution consists of paclitaxel or docetaxel, a pH regulator and a solvent for injection, wherein said solvent for injection is an organic solvent. Said emulsion includes a fat emulsion and is composed of oil for injection, an emulsifier, an antioxidant, an isotonic regulator, a stabilizer, a pH regulator and water for injection. When used, the drug solution at the clinical dosage can be added and mixed homogeneously in the emulsion to perform intravenous drip directly; or the drug solution at the clinical dosage can also be firstly added into the emulsion with no less than 5 times volume of the drug solution and then a predetermined amount of normal saline or glucose solution for injection is added to perform intravenous drip.
    Type: Application
    Filed: October 21, 2013
    Publication date: February 13, 2014
    Applicant: Tianjin Tasly Group Co., Ltd.
    Inventors: Jianming Chen, Baoan Gao, Jing Sun, Yue Zhang, Xiaoli Zheng, Ying Li, Dan Guo, Yang Zhang, Zhongbin Wu, Qiuxia Yang, Wei Liu, Peng Gu
  • Publication number: 20120157517
    Abstract: A pharmaceutical solution of taxanes, its preparation method, a composition comprising said solution and its pharmaceutical combination package are disclosed. Said pharmaceutical solution comprises taxanes, a pH regulator and a solvent, wherein the pH regulator is a water-soluble acid.
    Type: Application
    Filed: October 22, 2010
    Publication date: June 21, 2012
    Applicant: TIANJIN TASLY GROUP CO., LTD.
    Inventors: Jianming Chen, Baoan Gao, Li Deng, Qiuxia Yang, Jing Sun, Wei Liu, Peng Gu, Yingying Zhang, Jialiang Zhang
  • Publication number: 20110195136
    Abstract: The present invention relates to a drop pill for treating coronary heart disease, comprising an active pharmaceutical ingredient (API), a matrix adjuvant, a plastifying adjuvant, propylene glycol and water. the API is prepared from Radix salvia miltiorrhira, Panax notoginseng and Borneol; the matrix adjuvant is erythritol; the plastifying adjuvant is one or more selected from the group consisting of polyethylene glycols, xylitol, lactitol, mannitol, glycerine, soluble amylum, gelatin, methyl cellulose, sodium carboxymethycellulose (CMC-Na), hydroxypropyl methylcellulose (HPMC), arabic gum, alginic acid, dextrin, cyclodextrin (CD), citrate, glycerol acetate, dibutyl sebacate, refined coconut oil and castor oil; Wherein, relative to the total weight of the drop pill, the API is 1˜40 wt %, the plastifying adjuvant 0˜10 wt %, the propylene glycol 1˜10 wt %, the water 0˜10 wt % and the balance is the matrix adjuvant.
    Type: Application
    Filed: September 30, 2009
    Publication date: August 11, 2011
    Inventors: Jianming Chen, Xijun Yan, Yonghong Zhu, Baoan Gao, Shunnan Zhang, Haiou Dong, Jizhong Zhang, Wei Li, Xinjiang Yan, Ying Zhao
  • Publication number: 20110077291
    Abstract: The present invention relates to the field of medical technology. More specifically, the present invention relates to a preparation of taxanes for intravenous administration, which consists of two parts: a drug solution and an emulsion. Said drug solution consists of paclitaxel or docetaxel, a pH regulator and a solvent for injection, wherein said solvent for injection is an organic solvent. Said emulsion includes a fat emulsion and is composed of oil for injection, an emulsifier, an antioxidant, an isotonic regulator, a stabilizer, a pH regulator and water for injection. When used, the drug solution at the clinical dosage can be added and mixed homogeneously in the emulsion to perform intravenous drip directly; or the drug solution at the clinical dosage can also be firstly added into the emulsion with no less than 5 times volume of the drug solution and then a predetermined amount of normal saline or glucose solution for injection is added to perform intravenous drip.
    Type: Application
    Filed: September 30, 2009
    Publication date: March 31, 2011
    Inventors: Jianming Chen, Baoan Gao, Jing Sun, Yue Zhang, Xiaoli Zheng, Ying Li, Dan Guo, Yang Zhang, Zhongbin Wu, Qiuxia Yang, Wei Liu, Peng Gu