Patents by Inventor Bao Duong

Bao Duong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LONG GERMLINE DH GENES AND LONG HCDR3 ANTIBODIES
    Publication number: 20240175049
    Abstract: The invention relates to a long DH (LDH) cassette comprising a recombinant DH construct comprising at least two DH gene segments encoding at least 10 amino acids of the HCDR3 amino acid sequence, wherein at least one of the DH gene segments is a heterologous DH gene segment; an immunoglobulin heavy chain locus and a transgenic non-human animal comprising the same; and their use in producing an immunoglobulin library with long HCDR3 regions.
    Type: Application
    Filed: February 13, 2024
    Publication date: May 30, 2024
    Inventors: Matthias WABL, Werner MUELLER, Peter BURROWS, Gloria ESPOSITO, Bao DUONG
  • ENHANCED IMMUNOGLOBULIN DIVERSITY
    Publication number: 20240156071
    Abstract: The invention provides compositions and methods for enhanced production of immunoglobulin diversity. Specifically, the invention provides compositions and methods for making accessible a B cell receptor repertoire that has not been culled by developmental tolerance mechanisms. The invention also provides transgenic animals, cells, and antibodies resulting from these compositions and methods.
    Type: Application
    Filed: December 22, 2023
    Publication date: May 16, 2024
    Inventors: Matthias WABL, Bao DUONG, Werner MUELLER
  • Long germline DH genes and long HCDR3 antibodies
    Patent number: 11946063
    Abstract: The invention relates to a long DH (LDH) cassette comprising a recombinant DH construct comprising at least two DH gene segments encoding at least 10 amino acids of the HCDR3 amino acid sequence, wherein at least one of the DH gene segments is a heterologous DH gene segment; an immunoglobulin heavy chain locus and a transgenic non-human animal comprising the same; and their use in producing an immunoglobulin library with long HCDR3 regions.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: April 2, 2024
    Assignee: TRIANNI, INC.
    Inventors: Matthias Wabl, Werner Mueller, Peter Burrows, Gloria Esposito, Bao Duong
  • Enhanced immunoglobulin diversity
    Patent number: 11889821
    Abstract: The invention provides compositions and methods for enhanced production of immunoglobulin diversity. Specifically, the invention provides compositions and methods for making accessible a B cell receptor repertoire that has not been culled by developmental tolerance mechanisms. The invention also provides transgenic animals, cells, and antibodies resulting from these compositions and methods.
    Type: Grant
    Filed: September 23, 2020
    Date of Patent: February 6, 2024
    Assignee: TRIANNI, INC.
    Inventors: Matthias Wabl, Bao Duong, Werner Mueller
  • TRANSGENIC MAMMALS AND METHODS OF USE THEREOF
    Publication number: 20220369609
    Abstract: Transgenic mammals that express bovine-based immunoglobulins are described herein, including transgenic rodents that express bovine-based immunoglobulins for the development of bovine therapeutic antibodies.
    Type: Application
    Filed: June 30, 2020
    Publication date: November 24, 2022
    Inventors: Bao DUONG, Werner MUELLER, Peter Daniel BURROWS, Gloria ESPOSITO, Matthias WABL
  • ENHANCED PRODUCTION OF IMMUNOGLOBULINS
    Publication number: 20210292378
    Abstract: The present invention provides methods and compositions for generating transgenic animals, including transgenic mammals, as well as plasma cells that allow for cell surface capture of secreted immunoglobulin molecules produced endogenously in the plasma cells.
    Type: Application
    Filed: June 3, 2021
    Publication date: September 23, 2021
    Inventors: Nigel KILLEEN, Christoph HASENHINDL, Bao DUONG
  • Enhanced production of immunoglobulins
    Patent number: 11053288
    Abstract: The present invention provides methods and compositions for generating transgenic animals, including transgenic mammals, as well as plasma cells that allow for cell surface capture of secreted immunoglobulin molecules produced endogenously in the plasma cells.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: July 6, 2021
    Assignee: TRIANNI, INC.
    Inventors: Nigel Killeen, Christoph Hasenhindl, Bao Duong
  • TRANSGENIC MAMMALS AND METHODS OF USE THEREOF
    Publication number: 20210000087
    Abstract: Transgenic mammals that express canine-based immunoglobulins are described herein, including transgenic rodents that express canine-based immunoglobulins for the development of canine therapeutic antibodies.
    Type: Application
    Filed: June 30, 2020
    Publication date: January 7, 2021
    Inventors: Bao DUONG, Peter Daniel BURROWS, Werner MUELLER, Gloria ESPOSITO, Matthias WABL
  • ENHANCED IMMUNOGLOBULIN DIVERSITY
    Publication number: 20210000089
    Abstract: The invention provides compositions and methods for enhanced production of immunoglobulin diversity. Specifically, the invention provides compositions and methods for making accessible a B cell receptor repertoire that has not been culled by developmental tolerance mechanisms. The invention also provides transgenic animals, cells, and antibodies resulting from these compositions and methods.
    Type: Application
    Filed: September 23, 2020
    Publication date: January 7, 2021
    Inventors: Matthias WABL, Bao DUONG, Werner MUELLER
  • Enhanced immunoglobulin diversity
    Patent number: 10813346
    Abstract: The invention provides compositions and methods for enhanced production of immunoglobulin diversity. Specifically, the invention provides compositions and methods for making accessible a B cell receptor repertoire that has not been culled by developmental tolerance mechanisms. The invention also provides transgenic animals, cells, and antibodies resulting from these compositions and methods.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: October 27, 2020
    Assignee: TRIANNI, INC.
    Inventors: Matthias Wahl, Bao Duong, Nigel Killeen
  • ENHANCED PRODUCTION OF IMMUNOGLOBULINS
    Publication number: 20200190218
    Abstract: The present invention provides cells, transgenic animals, including transgenic mammals and particularly rodents, comprising engineered immunoglobulin alleles. Mutations in the alleles are designed to compromise allelic exclusion and have potential to be exploited for the isolation of bispecific antibodies.
    Type: Application
    Filed: February 27, 2020
    Publication date: June 18, 2020
    Inventors: Matthias WABL, Bao DUONG
  • ENHANCED IMMUNOGLOBULIN DIVERSITY
    Publication number: 20190053474
    Abstract: The invention provides compositions and methods for enhanced production of immunoglobulin diversity. Specifically, the invention provides compositions and methods for making accessible a B cell receptor repertoire that has not been culled by developmental tolerance mechanisms. The invention also provides transgenic animals, cells, and antibodies resulting from these compositions and methods.
    Type: Application
    Filed: November 30, 2016
    Publication date: February 21, 2019
    Inventors: Matthias Wabl, Bao Duong, Nigel Killeen
  • ENHANCED PRODUCTION OF IMMUNOGLOBULINS
    Publication number: 20170226162
    Abstract: The present invention provides methods and compositions for generating transgenic animals, including transgenic mammals, as well as plasma cells that allow for cell surface capture of secreted immunoglobulin molecules produced endogenously in the plasma cells.
    Type: Application
    Filed: February 3, 2017
    Publication date: August 10, 2017
    Inventors: Nigel Killeen, Christoph Hasenhindl, Bao Duong
  • ENHANCED PRODUCTION OF IMMUNOGLOBULINS
    Publication number: 20170058052
    Abstract: The present invention provides cells, transgenic animals, including transgenic mammals and particularly rodents, comprising engineered immunoglobulin alleles. Mutations in the alleles are designed to compromise allelic exclusion and have potential to be exploited for the isolation of bispecific antibodies.
    Type: Application
    Filed: August 24, 2016
    Publication date: March 2, 2017
    Inventors: Matthias Wabl, Bao Duong