Patents by Inventor Bao-li Chang

Bao-li Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF MICRO-RIBONUCLEIC ACID (MIRNA) TO DIAGNOSE TRANSPLANT REJECTION AND TOLERANCE OF IMMUNOSUPPRESSION THERAPY
    Publication number: 20190313957
    Abstract: The present invention relates to the discovery that the expression levels of some microRNAs (miRNAs) can use a diagnostic signature to predict transplant outcomes in a transplant recipient. Thus, in various embodiments described herein, the methods of the invention relate to methods of diagnosing a transplant subject for acute rejection such as acute cellular rejection (ACR), methods of predicting a subject's risk of having or developing ACR and methods of assessing in a subject the likelihood of a successful or failure minimization of immunosuppression therapy (IST) dosage from standard ranges.
    Type: Application
    Filed: March 26, 2019
    Publication date: October 17, 2019
    Inventors: Abraham Shaked, Bao-Li Chang, Brendan Keating, Toumy Guettouche
  • USE OF MICRO-RIBONUCLEIC ACID (MIRNA) TO DIAGNOSE TRANSPLANT REJECTION AND TOLERANCE OF IMMUNOSUPPRESSION THERAPY
    Publication number: 20170032100
    Abstract: The present invention relates to the discovery that the expression levels of some microRNAs (miRNAs) can use a diagnostic signature to predict transplant outcomes in a transplant recipient. Thus, in various embodiments described herein, the methods of the invention relate to methods of diagnosing a transplant subject for acute rejection such as acute cellular rejection (ACR), methods of predicting a subject's risk of having or developing ACR and methods of assessing in a subject the likelihood of a successful or failure minimization of immunosuppression therapy (IST) dosage from standard ranges.
    Type: Application
    Filed: April 10, 2015
    Publication date: February 2, 2017
    Applicant: The Trustees of the University of Pennslyvania
    Inventors: Abraham SHAKED, Bao-Li CHANG, Brendan KEATING, Toumy GUETTOUCHE
  • GENETIC POLYMORPHISMS IN THE PROSTATE-SPECIFIC ANTIGEN GENE PROMOTER
    Publication number: 20120003647
    Abstract: The present invention includes methods of identifying a subject at risk for increased cellular PSA production and/or prostate cancer by detecting the presence or absence of a genetic polymorphism in the prostate specific antigen gene.
    Type: Application
    Filed: June 30, 2011
    Publication date: January 5, 2012
    Inventors: Scott D. Cramer, Anuradha Rao, Jianfeng Xu, Bao-li Chang
  • Genetic polymorphisms in the prostate-specific antigen gene promoter
    Patent number: 7993843
    Abstract: The present invention includes methods of identifying a subject at risk for increased cellular PSA production and/or prostate cancer by detecting the presence or absence of a genetic polymorphism in the prostate specific antigen gene.
    Type: Grant
    Filed: March 10, 2010
    Date of Patent: August 9, 2011
    Assignee: Wake Forest University Health Sciences
    Inventors: Scott D. Cramer, Anuradha Rao, Jianfeng Xu, Bao-li Chang
  • GENETIC POLYMORPHISMS IN THE PROSTATE-SPECIFIC ANTIGEN GENE PROMOTER
    Publication number: 20100330566
    Abstract: The present invention includes methods of identifying a subject at risk for increased cellular PSA production and/or prostate cancer by detecting the presence or absence of a genetic polymorphism in the prostate specific antigen gene.
    Type: Application
    Filed: March 10, 2010
    Publication date: December 30, 2010
    Inventors: Scott D. Cramer, Anuradha Rao, Jianfeng Xu, Bao-li Chang
  • Genetic polymorphisms in the prostate-specific antigen gene promoter
    Patent number: 7718372
    Abstract: The present invention includes methods of identifying a subject at risk for increased cellular PSA production and/or prostate cancer by detecting the presence or absence of a genetic polymorphism in the prostate specific antigen gene.
    Type: Grant
    Filed: August 28, 2007
    Date of Patent: May 18, 2010
    Assignee: Wake Forest University Health Sciences
    Inventors: Scott D. Cramer, Anuradha Rao, Jianfeng Xu, Bao-li Chang
  • GENETIC POLYMORPHISMS IN THE PROSTATE-SPECIFIC ANTIGEN GENE PROMOTER
    Publication number: 20080038744
    Abstract: The present invention includes methods of identifying a subject at risk for increased cellular PSA production and/or prostate cancer by detecting the presence or absence of a genetic polymorphism in the prostate specific antigen gene.
    Type: Application
    Filed: August 28, 2007
    Publication date: February 14, 2008
    Inventors: Scott Cramer, Anuradha Rao, Jianfeng Xu, Bao-li Chang