Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds, and methods of using such compounds for treatment of joint damage or joint injury in a mammal, and for inducing differentiation of mesenchymal stem cells into chondrocytes.

Abstract: A method for providing cross-account data distribution management is disclosed. The method includes receiving an indication of a change in an object repository of a producer account, the change including an addition of data sets into the object repository; scheduling computing resources based on the indication and a predetermined guideline; identifying, via an application programming interface, parameters that correspond to a data warehouse of a consumer account; initiating the computing resources based on the scheduling to copy the data sets from the object repository to a producer data lake; transmitting, based on the identified parameters, the data sets from the producer data lake to a consumer data lake by using a managed data lake; and persisting the data sets from the consumer data lake in the data warehouse.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds; and methods of using such compounds for treating joint damage or injury in a mammal, for inducing hyaline cartilage production or for inducing differentiation of chondrogenic progenitor cells into mature chondrocytes.

Abstract: A method for managing an activation state of a current node of a first wireless communication network that also includes a neighbor node. The current node including a first radio hosting a first access point to a core network, and a second radio hosting a second access point to a user network that is configured to connect the client device to the current node. The method includes, upon receipt of a communication request by the current node, reactivation of the other of the first and second radios, when said current node is in a partially deactivated state, and when it has been determined that a connection of the current node to the core network is required to process said communication request, reactivation of the at least one neighbor node by the current node sending a discovery request on at least one radio of said at least one neighbor node.

Abstract: Disclosed herein are methods and systems for rapid detection of antibiotic resistance of a microorganism in a sample. A modified recombinant phage is also disclosed which comprises an indicator gene in the late gene region. The specificity of infectious agents allows a specific microorganism to be targeted, and an indicator signal may be amplified to optimize assay sensitivity.

Abstract: Disclosed herein are methods and systems for rapid detection of microorganisms such as Cronobacter spp. in a sample. A genetically modified bacteriophage is also disclosed which comprises an indicator gene in the late gene region. The specificity of the bacteriophage, such as Cronobacter-specific bacteriophage, allows detection of a specific microorganism, such as Cronobacter spp. and an indicator signal may be amplified to optimize assay sensitivity.

Abstract: A magnetic device includes a first magnetic layer, a second magnetic layer, and a nonmagnetic layer between the first and second magnetic layers and including: a first layer in contact with the first magnetic layer and including a magnesium oxide, a second layer in contact with the second magnetic layer and including a magnesium oxide, and a third layer between the first and second layers and including a scandium nitride.

Abstract: Embodiments of the present invention are directed to a Content Delivery Network (CDN) for broadcasting data streams. The CDN allows a streamer to stream live (in realtime) on a network(s), such as the Internet, for a live audience to view and to interact with the live entertainment. Each of the broadcast clients send data streams to the CDN via an input node, wherein the CDN output a selected media stream to one or more selected viewing clients via the output node. The architecture of the CDN contains one or more System Racks. Each of the System Racks contains multiple media channels. In operation, the data stream of a broadcasting client is sent to the CDN and distributed into selected channels. The data streams in each of the selected channels are outputted to viewing clients of a corresponding type.

Abstract: The present invention relates to a composition for the prevention or treatment of a muscle disease, comprising an extract of Ponciri Fructus. The extract of the present invention has the effect of increasing the expression of genes related to myotube cell differentiation and/or athletic performance, increasing muscle weight, and/or improving athletic performance.

Abstract: Methods, systems, and devices for data management are described. A database for managing one or more subscriptions to a cloud service that provides computing resources may be generated. The database may include multiple tables corresponding to multiple geographic regions. Based on the subscriptions, the tables may be updated to reflect respective computing resource allotments for respective geographic regions. A request to apply a software-as-a-service product to customer data may be received from a geographic region. In response to the request, available computing resources for the geographic region may be identified and a determine of whether to configure the available computing resources for the instantiation of the software-as-a-service product instance may be determined. Based on the determining, an indication of whether the software-as-a-service product instance is initiated may be provided.

Abstract: A system for detecting refractive power of a dry ophthalmic lens under inspection, comprising: a) a top camera 10 arranged to view the ophthalmic lens 40 through an optical module 25; b) an optically transparent surface 30 to position the ophthalmic lens 40 for inspection; c) a precisely calibrated glass target 50 suitably positioned on a transparent plate 60, arranged to achieve an image of the ophthalmic lens 40 overlaid with the image of the pattern on the target 50; d) at least one light source having multiple wavelength LEDs to capture different images under multiple lighting conditions.

Abstract: Disclosed herein are methods and systems for rapid detection of microorganisms in a sample. A genetically modified bacteriophage is also disclosed which comprises an indicator gene in the late gene region. The specificity of the bacteriophage, such as Salmonella-specific bacteriophage, allows detection of a specific microorganism, such as Salmonella spp. and an indicator signal may be amplified to optimize assay sensitivity.

Abstract: This disclosure describes enhanced substrate transfer arm (STA) and pedestal designs related to a thermal compression bonding process. The designs include multiple row patterns of the STA and the pedestal used to: pick up a first substrate row from a first row of a tray; place the first substrate row onto a first row of a bond stage corresponding to the first row of the tray; pick up a second substrate row from the tray; place, using the suction cups, the second substrate row onto a remaining empty row of the bond stage; pick up the first substrate row after thermal bonding from the bond stage; place the first substrate row after thermal bonding onto the tray; when all substrates from the tray have been thermally bonded, pick up a last substrate row after thermal bonding from the bond stage; and place the last substrate row onto the tray.

Abstract: An illustrative method includes accessing data representative of a first role associated with a set of permissions with respect to resources within the compute environment and specifying a group of identities assigned to the first role, determining that a first subgroup of one or more identities included the group of identities only uses a first subset of permissions included in the set of permissions to access the resources within the compute environment without using a second subset of permissions, and performing, based on the determining that the first subgroup of one or more identities only uses the first subset of permissions, an operation to reduce permissions usable by the one or more identities.

Abstract: Disclosed herein are methods and systems for rapid detection of antibiotic resistance of a microorganism in a sample. A modified recombinant phage is also disclosed which comprises an indicator gene in the late gene region. The specificity of infectious agents allows a specific microorganism to be targeted, and an indicator signal may be amplified to optimize assay sensitivity.

Abstract: Disclosed herein are system, apparatus, article of manufacture, method and/or computer program product embodiments, and/or combinations and sub-combinations thereof, for tailoring and censoring content based on audience detected. An example embodiment operates by detecting an audience within a vicinity of a media device based on identifying information received by the media device, determining a category of the audience with a user identification system based on the identifying information, identifying a content tailoring rule for the audience based on the category of the audience, retrieving a content to be played by the media device, and modifying the content based on the content tailoring rule and a category label of the content.

Abstract: A system for identifying defects and measuring geometric dimensions in cosmetic ophthalmic lens immersed in a Saline solution, the system, comprising: a) at least one camera for obtaining images of the cosmetic ophthalmic lens, the camera having an optical axis; b) at least one electronically controlled illumination module designed with Visible and infrared LEDs, segmented accordingly and suitably integrated to be positioned along the vertical optical axis for directing light at different angles of the cosmetic ophthalmic lens; c) a customised glass cuvette designed with concave, concentric and spherical surfaces to avoid adding more optical power to the cosmetic ophthalmic lens under inspection and with the radius of the interior surface of the cuvette designed to be bigger than the lens to enable locating the cosmetic ophthalmic lens to the centre of the cuvette during inspection; d) a strobe controller integrated to the illumination module and Camera that is capable of capturing multiple images in quick su

Abstract: Method for communicating via an API, including the steps of: producing a structural description of each version of the transaction; producing a signature which is representative of the structural description of the version; defining and saving an object comprising the signature and the structural description of the version; causing a transmitting software entity to transmit a current message of a current version of the transaction and a current signature of the current version; causing a receiving software entity to receive the current message and the current signature; causing the receiving software entity to identify an object having a signature identical to the current signature, and decoding the current message using the structural description of the object.

Abstract: Disclosed herein are methods and systems for rapid detection of microorganisms in a sample. A genetically modified bacteriophage is also disclosed which comprises an indicator gene in the late gene region. The specificity of the bacteriophage, such as Salmonella-specific bacteriophage, allows detection of a specific microorganism, such as Salmonella spp. and an indicator signal may be amplified to optimize assay sensitivity.

Abstract: A method and system for auto-curating a media are provided. Media content is received over the network interface. A set of markers is identified for the media content, each marker corresponding to one of a plurality of visible and audible cues in the media content. Segments in the media content are identified based on the identified set of markers. An excitement score is computed for each segment based on the identified markers that fall within the segment. A highlight clip is generated by identifying segments having excitement scores greater than a threshold.