Patents by Inventor Bao-Shan Huang
Bao-Shan Huang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9487532Abstract: Methods are provided which include converting oripavine to other opiates, including converting oripavine to naltrexone, buprenorphine, 14-hydroxymorphinone and/or converting 14-hydroxymorphinone to oxymorphone. Purification and salt formation are optionally included.Type: GrantFiled: October 23, 2013Date of Patent: November 8, 2016Assignee: PENICK CORPORATIONInventor: Bao-Shan Huang
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Patent number: 9108974Abstract: Methods are provided which include converting oripavine to other opiates, including converting oripavine to naltrexone, buprenorphine, 14-hydroxymorphinone and/or converting 14-hydroxymorphinone to oxymorphone. Purification and salt formation are optionally included.Type: GrantFiled: October 16, 2007Date of Patent: August 18, 2015Assignee: PENICK CORPORATIONInventor: Bao-Shan Huang
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Publication number: 20140051861Abstract: Methods are provided which include converting oripavine to other opiates, including converting oripavine to naltrexone, buprenorphine, 14-hydroxymorphinone and/or converting 14-hydroxymorphinone to oxymorphone. Purification and salt formation are optionally included.Type: ApplicationFiled: October 23, 2013Publication date: February 20, 2014Applicant: PENICK CORPORATIONInventor: Bao-Shan HUANG
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Patent number: 8357802Abstract: Methods are provided which include converting oripavine to other opiates, including converting oripavine to naltrexone, buprenorphine, 14-hydroxymorphinone and/or converting 14-hydroxymorphinone to oxymorphone. Purification and salt formation are optionally included.Type: GrantFiled: January 25, 2011Date of Patent: January 22, 2013Assignee: Penick CorporationInventor: Bao-Shan Huang
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Publication number: 20120330017Abstract: Methods are provided which include converting oripavine to other opiates, including converting oripavine to naltrexone, buprenorphine, 14-hydroxymorphinone and/or converting 14-hydroxymorphinone to oxymorphone. Purification and salt formation are optionally included.Type: ApplicationFiled: August 31, 2012Publication date: December 27, 2012Applicant: PENICK CORPORATIONInventor: Bao-Shan HUANG
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Publication number: 20120196888Abstract: Methods are provided which include converting oripavine to other opiates, including converting oripavine to naltrexone, buprenorphine, 14-hydroxymorphinone and/or converting 14-hydroxymorphinone to oxymorphone. Purification and salt formation are optionally included.Type: ApplicationFiled: February 28, 2012Publication date: August 2, 2012Applicant: PENICK CORPORATIONInventor: Bao-Shan HUANG
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Publication number: 20120156290Abstract: Methods are provided which include converting oripavine to other opiates, including converting oripavine to naltrexone, buprenorphine, 14-hydroxymorphinone and/or converting 14-hydroxymorphinone to oxymorphone. Purification and salt formation are optionally included.Type: ApplicationFiled: February 28, 2012Publication date: June 21, 2012Applicant: PENICK CORPORATIONInventor: Bao-Shan HUANG
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Patent number: 8134002Abstract: Methods are provided which include converting oripavine to other opiates, including converting oripavine to 14-hydroxymorphinone and/or converting 14-hydroxymorphinone to oxymorphone. Purification and salt formation are optionally included.Type: GrantFiled: May 2, 2007Date of Patent: March 13, 2012Assignee: Penick CorporationInventor: Bao-Shan Huang
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Publication number: 20110118466Abstract: Methods are provided which include converting oripavine to other opiates, including converting oripavine to naltrexone, buprenorphine, 14-hydroxymorphinone and/or converting 14-hydroxymorphinone to oxymorphone. Purification and salt formation are optionally included.Type: ApplicationFiled: January 25, 2011Publication date: May 19, 2011Applicant: Penick CorporationInventor: Bao-Shan HUANG
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Publication number: 20110009634Abstract: Methods are provided which include converting oripavine to other opiates, including converting oripavine to 14-hydroxymorphinone and/or converting 14-hydroxymorphinone to oxymorphone. Purification and salt formation are optionally included.Type: ApplicationFiled: May 2, 2007Publication date: January 13, 2011Applicant: PENICK CORPORATIONInventor: Bao-Shan Huang
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Publication number: 20100274019Abstract: Methods are provided which include converting oripavine to other opiates, including converting oripavine to naltrexone, buprenorphine, 14-hydroxymorphinone and/or converting 14-hydroxymorphinone to oxymorphone. Purification and salt formation are optionally included.Type: ApplicationFiled: October 16, 2007Publication date: October 28, 2010Applicant: PENICK CORPORATIONInventor: Bao-Shan Huang
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Publication number: 20080125592Abstract: Methods are provided which include converting oripavine to other opiates, including converting oripavine to naltrexone, buprenorphine, 14-hydroxymorphinone and/or converting 14-hydroxymorphinone to oxymorphone. Purification and salt formation are optionally included.Type: ApplicationFiled: October 16, 2007Publication date: May 29, 2008Applicant: PENICK CORPORATIONInventor: Bao-Shan Huang
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Patent number: 6013796Abstract: For the synthesis of 3-methylnaltrexone from codeine in this invention, codeine is converted to 6-acetylcodeine, which is N-demethylated to 6-acetylcodeine hydrochloride, followed by alkylating the nitrogen to form 17-cyclopropylmethylnorcodeine. The latter is oxidized to 17-cyclopropylmethylnorcodeinone. For the synthesis of naltrexone from morphine in this invention, morphine is converted to 3-benzylnormorphine as described above in the synthesis of noroxymorphone. 3-Benzylnormorphine is reacted with cyclopropylmethyl halide to produce 3-benzyl-17cyclopropylmethylnormorphine, a novel compound, which is oxidized to 3-benzyl-17-cyclopropylmethyl-normorphinone, a novel compound, by Swern oxidation.Type: GrantFiled: July 16, 1998Date of Patent: January 11, 2000Assignee: Penick CorporationInventors: Bao-Shan Huang, Yansong Lu, Ben-Yi Ji, Aris P Christodoulou
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Patent number: 6008355Abstract: A process is provided for preparing oxycodone from codeine comprising either:(A) the steps of(1) oxidizing codeine so as to form codeinone;(2) converting codeinone to oxycodone in a two-step-one-pot reaction: first reacting codeinone with hydrogen peroxide in water in the presence of an acid at from about 15.degree. to about 70.degree. C. to form 14-hydroxycodeinone and then catalytically hydrogenating 14-hydroxycodeinone in its original reaction mixture to form oxycodone; or(B) the steps of(1) oxydizing codeine so as to form codeinone;(2) reacting codeinone with an acylating agent so as to form codeinone dienol acylate;(3) oxidizing codeinone dienol acylate with an oxidation agent in water or a solubilizing solvent mixture in the presence of an acid at from about 15.degree. to about 70.degree. C. to form 14-hydroxycodeinone;(4) hydrogenating 14-hydroxycodeinone in its original reaction mixture to form oxycodone.Type: GrantFiled: July 16, 1998Date of Patent: December 28, 1999Assignee: Penick CorporationInventors: Bao-Shan Huang, Yansong Lu, Ben-Yi Ji, Aris P Christodoulou
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Patent number: 6008354Abstract: The invention provides processes for the conversion of normorphinone and its derivatives, which can be synthesized from morphine, to the corresponding 14-hydroxynormorphinone and its derivatives including oxycodone, oxymorphone, noroxymorphone and naltrexone. Noroxymorphone is a key intermediate for the production of important narcotic analgesics and antagonists. The invention also provides certain novel intermediates.Type: GrantFiled: July 16, 1998Date of Patent: December 28, 1999Assignee: Penick CorporationInventors: Bao-Shan Huang, Yansong Lu, Ben-Yi Ji, Aris P. Christodoulou
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Patent number: 5952495Abstract: A process is provided for preparing 14-hydroxynormorphinones having the formula: ##STR1## which comprises reacting normorphinones having the formula: ##STR2## wherein R is selected from the group consisting of lower alkyl of 1 to 7 carbon atoms, cycloalkyl-lower alkyl with 3-6 ring carbon atoms, benzyl and a substituted-benzyl having the formula: ##STR3## wherein Q and Q.sup.1 are individually selected from the group consisting of hydrogen, lower alkyl, trifluoromethyl, nitro, dialkylamino and cyano;R' is selected from the group consisting of R, 2-(4-morpholinyl)ethyl, benzyloxy carbonyl and R"C(O)-- wherein R" is lower alkyl of 1-4 carbon atoms;with hydrogen peroxide at a temperature of from about 15.degree. C. to about 70.degree. C. in the presence of an acid and an aqueous solvent system to solubilize the reactant for a period of time so as to form the 14-hydroxynormorphinones.Type: GrantFiled: July 16, 1998Date of Patent: September 14, 1999Assignee: Penick CorporationInventors: Bao-Shan Huang, Yansong Lu, Ben-Yi Ji, Aris P Christodoulou
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Patent number: 5948788Abstract: Normorphine and normorphinone derivatives are provided as compositions of matter.Type: GrantFiled: July 17, 1998Date of Patent: September 7, 1999Assignee: Penick CorporationInventors: Bao-Shan Huang, Yansong Lu, Ben-Yi Ji, Aris P Christodoulou
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Patent number: 5922876Abstract: A process is provided for preparing oxymorphone from morphine by: (a) reacting morphine with an acyl halide or anhydride to form 3-acylmorphine, or (b) reacting morphine with benzyl-halide to form 3-benzylmorphine, and thereafter either by (3a) or (3b):(3a) introducing a .beta.-oriented hydroxy group at the 14-position of the 3-acyl- or 3-benzyl-morphinone with aqueous hydrogen peroxide and an acid at at temperature of about 15.degree. to about 70.degree. C. to form the 3-acyl or 3-benzyl-14-hydroxymorphinone;(3b) acylating the 3-acyl or 3-benzyl-morphinone with an acylating agent so as to form the dienol acylate followed by oxidizing the dienol acetate to the corresponding 3-acyl or 3-benzyl-14-hydroxymorphinone;(4) hydrogenating the 3-acyl-14-hydroxymorphinone with a catalyst so as to form the 3-acyloxymorphone;(5) hydrolyzing the 3-acyl-oxymorphone with aqueous acidic or basic solution to form oxymorphone;(6) hydrogenating the 3-benzyl-14-hydroxymorphinone with a catalyst so as to form oxymorphone.Type: GrantFiled: July 16, 1998Date of Patent: July 13, 1999Assignee: Penick CorporationInventors: Bao-Shan Huang, Yansong Lu, Ben-Yi Ji, Aris P Christodoulou
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Patent number: 5869669Abstract: The invention provides processes for the conversion of normorphinone and its derivatives, which can be synthesized from morphine, to the corresponding 14-hydroxynormorphinone and its derivatives including oxycodone, oxymorphone, noroxymorphone and naltrexone. Noroxymorphone is a key intermediate for the production of important narcotic analgesics and antagonists. The invention also provides certain novel intermediates.Type: GrantFiled: July 11, 1997Date of Patent: February 9, 1999Assignee: Penick CorporationInventors: Bao-Shan Huang, Yansong Lu, Ben-Yi Ji, Aris P. Christodoulou
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Patent number: 5262537Abstract: This invention pertains to a method for treating a condition of nausea and vomiting in a mammal which comprises administering a therapeutically effective amount of a 4,5,6,7-tetrahydroimidazo[4,5-c]pyridinyl-6-carboxylic acid derivative represented by the formula: ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen or lower-alkyl; R.sub.3 is selected from the group consisting of hydrogen, lower-alkyl, nitro, amino, cyano, and alkylmercapto; R.sub.4 and R.sub.5 are selected from the group consisting of hydrogen, lower-alkyl, aryl, and aryl lower-alkyl, or R.sub.4 and R.sub.5 together with the carbon atom to which they are attached form a 5- or 6-member saturated hydrocarbon ring; R.sub.6 is selected from the group consisting of hydrogen, lower-alkyl, aryl lower-alkyl, formyl, lower-alkyl carbonyl, and aryl carbonyl; R.sub.7 is selected from the group consisting of phenyl, thienyl, indolyl, indazolyl, benzo[b]furanyl, benzo[b]thiophenyl, and R.sub.8 R.sub.9 --N--; R.sub.Type: GrantFiled: March 19, 1993Date of Patent: November 16, 1993Assignee: Anaquest, Inc.Inventors: Bao-Shan Huang, Danging D. Feng, Martin Gall, Suzanne M. Evans, Vidyadhar M. Paradkar, Raghunathan V. Nair, Tamara B. Latham