Patents by Inventor Baochuan Lin
Baochuan Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10501776Abstract: Mesoporous sorbents are effective for storing and transporting nucleic acids. In particular, two ethane-bridged silica sorbents with amine functionalities are particularly effective and capable of binding nucleic acids for storage.Type: GrantFiled: August 21, 2018Date of Patent: December 10, 2019Assignee: The Government of the United States of America, as represented by the secretary of the NavyInventors: Baochuan Lin, Brandy J. White, Brian Melde
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Publication number: 20190017098Abstract: Mesoporous sorbents are effective for storing and transporting nucleic acids. In particular, two ethane-bridged silica sorbents with amine functionalities are particularly effective and capable of binding nucleic acids for storage.Type: ApplicationFiled: August 21, 2018Publication date: January 17, 2019Inventors: Baochuan Lin, Brandy J. White, Brian Melde
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Patent number: 10077465Abstract: Mesoporous sorbents are effective for storing and transporting nucleic acids. In particular, two ethane-bridged silica sorbents with amine functionalities are particularly effective and capable of binding nucleic acids for storage.Type: GrantFiled: September 13, 2016Date of Patent: September 18, 2018Assignee: The United States of America, as represented by the Secretary of the NavyInventors: Baochuan Lin, Brandy J. White, Brian Melde
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Publication number: 20180073052Abstract: Mesoporous sorbents are effective for storing and transporting nucleic acids. In particular, two ethane-bridged silica sorbents with amine functionalities are particularly effective and capable of binding nucleic acids for storage.Type: ApplicationFiled: September 13, 2016Publication date: March 15, 2018Inventors: Baochuan Lin, Brandy J. White, Brian Melde
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Patent number: 9430610Abstract: The present invention relates to pathogen detection and identification by use of DNA resequencing microarrays. The present invention also provides resequencing microarray chips for differential diagnosis and serotyping of pathogens present in a biological sample. The present invention further provides methods of detecting the presence and identity of pathogens present in a biological sample.Type: GrantFiled: April 10, 2008Date of Patent: August 30, 2016Assignee: The United States of America, as represented by the Secretary of the NavyInventors: Brian K Agan, Eric H Hanson, Russell P Kruzelock, Baochuan Lin, Robb K Rowley, Donald Seto, David A Stenger, Jennifer Johnson, Clark J Tibbetts, Dzung C Thach, Gary J Vora, Elizabeth A Walter, Zheng Wang
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Patent number: 9296771Abstract: A method of attaching a phosphorous dendrimer onto magnetic microparticles by taking magnetic microparticles in a water-based solution, then performing a solvent exchange, then suspending the microparticles in a phosphorous dendrimer solution and shaking, then washing the microparticles with an organic solvent, and then washing the microparticles with a transition solvent. The solvent exchange is done by washing the microparticles with a first concentration of a transition solvent, then washing the microparticles with a second concentration of the transition solvent where the second concentration is greater than the first concentration, then washing the microparticles with an organic solvent, then washing the microparticles with the transition solvent, then washing the microparticles with the organic solvent, and then suspending the microparticles in the transition solvent. Also disclosed is the related phosphorous dendrimer made by this method.Type: GrantFiled: March 13, 2014Date of Patent: March 29, 2016Assignee: The United States of America, as represented by the Secretary of the NavyInventors: Marie J. Archer, Baochuan Lin
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Patent number: 9096849Abstract: A method of: providing a solid surface having a dendrimer molecule bound thereto and a single-stranded probe nucleic acid immobilized to the dendrimer; contacting the solid surface with a sample suspected or known to contain a double-stranded complimentary target nucleic acid; denaturing the target nucleic acids at thermal conditions and in a salt concentration sufficient to denature the target nucleic acids to produce denatured nucleic acids; and cooling the sample to allow hybridization of the denatured nucleic acids to the probe nucleic acids. An article having: one or more paramagnetic microbeads; a dendrimer molecule bound to the beads; and a probe nucleic acid immobilized to the dendrimer.Type: GrantFiled: May 21, 2007Date of Patent: August 4, 2015Assignee: The United States of America, as represented by the Secretary of the NavyInventors: Marie J. Archer, Baochuan Lin, David A Stenger
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Patent number: 9040250Abstract: A composition having proanthocyanidin compounds having an average degree of polymerization of at least about 6. A method of administering to an immunosuppressed patient or a patient diagnosed with sepsis or septic shock a composition having a proanthocyanidin. A method of administering to a patient diagnosed with a gram negative bacterial infection a composition having proanthocyanidin compounds having an average degree of polymerization of at least about 6.Type: GrantFiled: August 2, 2007Date of Patent: May 26, 2015Assignee: The United States of America, as represented by the Secretary of the NavyInventors: James B Delehanty, Brandy J White, Baochuan Lin, Frances S Ligler
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Publication number: 20140275628Abstract: A method of attaching a phosphorous dendrimer onto magnetic microparticles by taking magnetic microparticles in a water-based solution, then performing a solvent exchange, then suspending the microparticles in a phosphorous dendrimer solution and shaking, then washing the microparticles with an organic solvent, and then washing the microparticles with a transition solvent. The solvent exchange is done by washing the microparticles with a first concentration of a transition solvent, then washing the microparticles with a second concentration of the transition solvent where the second concentration is greater than the first concentration, then washing the microparticles with an organic solvent, then washing the microparticles with the transition solvent, then washing the microparticles with the organic solvent, and then suspending the microparticles in the transition solvent. Also disclosed is the related phosphorous dendrimer made by this method.Type: ApplicationFiled: March 13, 2014Publication date: September 18, 2014Inventors: Marie J. Archer, Baochuan Lin
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Patent number: 8715949Abstract: A composition having: a proanthocyanidin; and a macromolecule, an assembly of macromolecules, a semi-solid, or a solid surface to which the proanthocyanidin is immobilized.Type: GrantFiled: August 2, 2007Date of Patent: May 6, 2014Assignee: The United States of America, as represented by the Secretary of the NavyInventors: James B Delehanty, Brandy J White, Baochuan Lin, Frances S Ligler
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Publication number: 20110183856Abstract: The present invention provides a specific set of gene expression markers from peripheral blood leukocytes that are indicative of a host response to exposure, response, and recovery infectious pathogen infections. The present invention further provides methods for identifying the specific set of gene expression markers, methods of monitoring disease progression and treatment of infectious pathogen infections, methods of prognosing the onset of an infectious pathogen infection, and methods of diagnosing an infectious pathogen infection and identifying the pathogen involved.Type: ApplicationFiled: February 26, 2010Publication date: July 28, 2011Applicants: The Government of the United States of America, as represented by the Secretary of the NavyInventors: Brian K. Agan, Eric H. Hanson, Michael J. Jenkins, Baochuan Lin, Chris C. Olsen, Robb K. Rowley, David A. Stenger, Dzung C. Thach, Clark J. Tibbetts, Elizabeth A. Walter, Jinny Lin Liu
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Patent number: 7979446Abstract: A method of: submitting reference sequences to a taxonomic database to produce taxonomic results; and reporting a taxonomic identification based on the taxonomic results. The reference sequences are the output of genetic database queries that return a score for each reference sequence. A method for processing a biological sequence obtained from an assay by: converting base calls located in a predetermined list of positions within the biological sequence to N; and determining the ratio of single nucleotide polymorphisms in the biological sequence relative to a reference sequence. Each entry in the predetermined list of positions represents the capability of a substance hybridizing to a microarray used to generate the biological sequence. The substance is not the nucleic acid of a target pathogen.Type: GrantFiled: November 12, 2009Date of Patent: July 12, 2011Assignee: The United States of America as represented by the Secretary of the NavyInventors: Anthony P. Malanoski, Baochuan Lin, Joel M Schnur, David A Stenger
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Publication number: 20100112643Abstract: A method of: providing a solid surface having a dendrimer molecule bound thereto and a single-stranded probe nucleic acid immobilized to the dendrimer; contacting the solid surface with a sample suspected or known to contain a target ribonucleic acid; denaturing the target ribonucleic acid; and incubating the sample to allow hybridization of the denatured ribonucleic acid to the probe nucleic acids. The target ribonucleic acid is complementary to the probe nucleic acid.Type: ApplicationFiled: November 4, 2008Publication date: May 6, 2010Applicant: The Government of the United States of America, as represented by the Secretary of the NavyInventors: Marie J. Archer, Baochuan Lin, David A. Stenger
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Patent number: 7695941Abstract: A PCR method involving: providing a biological sample suspected of containing one or more pathogen nucleic acids; adding a plurality of PCR primers corresponding to genes found in the pathogens; and performing a polymerase chain reaction on the sample to amplify a subset of the nucleic acids that correspond to the genes. The primers include at least one primer pair for each pathogen, and the primers contain a tail sequence that is not homologous any pathogen DNA or to any background DNA in the sample. The concentration of at least one primer in the polymerase chain reaction is no more than about 100 nM.Type: GrantFiled: June 6, 2006Date of Patent: April 13, 2010Assignee: The United States of America as represented by the Secretary of the NavyInventors: Baochuan Lin, Kate M. Blaney, Anthony P. Malanoski, Joel M Schnur, David A Stenger
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Publication number: 20100070195Abstract: A method of: submitting reference sequences to a taxonomic database to produce taxonomic results; and reporting a taxonomic identification based on the taxonomic results. The reference sequences are the output of genetic database queries that return a score for each reference sequence. A method for processing a biological sequence obtained from an assay by: converting base calls located in a predetermined list of positions within the biological sequence to N; and determining the ratio of single nucleotide polymorphisms in the biological sequence relative to a reference sequence. Each entry in the predetermined list of positions represents the capability of a substance hybridizing to a microarray used to generate the biological sequence. The substance is not the nucleic acid of a target pathogen.Type: ApplicationFiled: November 12, 2009Publication date: March 18, 2010Applicant: The Government of the United States of America, as represented by the Secretary of the NavyInventors: Anthony P. Malanoski, Baochuan Lin, Joel M. Schnur, David A. Stenger
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Patent number: 7668664Abstract: A computer-implemented method as follows. Providing a list of target sequences associated with one or more organisms. Providing a list of candidate prototype sequences suspected of hybridizing to one or more of the target sequences. Generating a collection of probes corresponding to each candidate prototype sequence, each collection of probes having a set of probes for every subsequence. The sets consist of the corresponding subsequence and every variation of the corresponding subsequence formed by varying a center nucleotide of the corresponding subsequence. Generating a set of fragments corresponding to each target sequence. Calculating the binding free energy of each fragment with a perfect complimentary sequence of the fragment. Determining which extended fragments are perfect matches to any of the probes. Assembling a base call sequence corresponding to each candidate prototype sequence.Type: GrantFiled: August 22, 2007Date of Patent: February 23, 2010Assignee: The United States of America as represented by the Secretary of the NavyInventors: Anthony P. Malanoski, Zheng Wang, Baochuan Lin, David A Stenger, Joel M Schnur
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Patent number: 7623997Abstract: A method of: submitting reference sequences to a taxonomic database to produce taxonomic results; and reporting a taxonomic identification based on the taxonomic results. The reference sequences are the output of genetic database queries that return a score for each reference sequence. A method for processing a biological sequence obtained from an assay by: converting base calls located in a predetermined list of positions within the biological sequence to N; and determining the ratio of single nucleotide polymorphisms in the biological sequence relative to a reference sequence. Each entry in the predetermined list of positions represents the capability of a substance hybridizing to a microarray used to generate the biological sequence. The substance is not the nucleic acid of a target pathogen.Type: GrantFiled: June 6, 2006Date of Patent: November 24, 2009Assignee: The United States of America as represented by the Secretary of the NavyInventors: Anthony P. Malanoski, Baochuan Lin, Joel M Schnur, David A Stenger
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Publication number: 20090170717Abstract: The present invention relates to pathogen detection and identification by use of DNA resequencing microarrays. The present invention also provides resequencing microarray chips for differential diagnosis and serotyping of pathogens present in a biological sample. The present invention further provides methods of detecting the presence and identity of pathogens present in a biological sample.Type: ApplicationFiled: April 10, 2008Publication date: July 2, 2009Applicants: The Government of the United States of America, as represented by the Secretary of the Navy, The Government of the United States of America, as represented by the Secretary of the Air ForceInventors: Brian K. Agan, Eric H. Hanson, Russell P. Kruzelock, Baochuan Lin, Robb K. Rowley, Donald Seto, David A. Stenger, Jennifer Johnson, Clark J. Tibbetts, Dzung C. Thach, Gary J. Vora, Elizabeth A Walter, Zheng Wang
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Publication number: 20080293594Abstract: A method of: providing a solid surface having a dendrimer molecule bound thereto and a single-stranded probe nucleic acid immobilized to the dendrimer; contacting the solid surface with a sample suspected or known to contain a double-stranded complimentary target nucleic acid; denaturing the target nucleic acids at thermal conditions and in a salt concentration sufficient to denature the target nucleic acids to produce denatured nucleic acids; and cooling the sample to allow hybridization of the denatured nucleic acids to the probe nucleic acids. An article having: one or more paramagnetic microbeads; a dendrimer molecule bound to the beads; and a probe nucleic acid immobilized to the dendrimer.Type: ApplicationFiled: May 21, 2007Publication date: November 27, 2008Applicant: The Govermment of the US, as represented by the Secretary of the NavyInventors: Marie J. Archer, Baochuan Lin, David A. Stenger
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Publication number: 20080176933Abstract: A composition having proanthocyanidin compounds having an average degree of polymerization of at least about 6. A method of administering to an immunosuppressed patient or a patient diagnosed with sepsis or septic shock a composition having a proanthocyanidin. A method of administering to a patient diagnosed with a gram negative bacterial infection a composition having proanthocyanidin compounds having an average degree of polymerization of at least about 6.Type: ApplicationFiled: August 2, 2007Publication date: July 24, 2008Applicant: The Government of the US, as represented by the Secretary of the NavyInventors: James B. Delehanty, Brandy J. White, Baochuan Lin, Frances S. Ligler