Abstract: The present disclosure is related to a derivative of berberine, and the preparation method and applications thereof. The present derivative of berberine has a significant anti-myocardial ischemic effect, and its preparation route is feasible and reasonable with lower cost, less toxic and harmful reagents used, no environmental contamination, and is suitable for large-scale production. The cardioprotective derivative of berberine developed in the present disclosure and the preparation method thereof effectively provide a basis for developing novel cardioprotective medicaments, have a great economic benefit in the future, and bring a broad social benefit, leading to promising application prospects.

Abstract: A polypeptide, a composition containing the polypeptide, and a use thereof in preparing a drug for preventing and/or treating neuroblastoma.

Abstract: The present disclosure is related to a derivative of berberine, and the preparation method and applications thereof. The present derivative of berberine has a significant anti-myocardial ischemic effect, and its preparation route is feasible and reasonable with lower cost, less toxic and harmful reagents used, no environmental contamination, and is suitable for large-scale production. The cardioprotective derivative of berberine developed in the present disclosure and the preparation method thereof effectively provide a basis for developing novel cardioprotective medicaments, have a great economic benefit in the future, and bring a broad social benefit, leading to promising application prospects.

Abstract: A polypeptide, a composition containing the polypeptide, and a use thereof in preparing a drug for preventing and/or treating neuroblastoma.

Abstract: Disclosed in the present invention are an emodin succinyl ester compound, a preparation method therefor and a use thereof, the emodin succinyl ester compound having the structure as represented by formula I (R being a C1-5 alkyl group). The method provided in the present invention has a simple method course, and may effectively save time in synthesis and reduce costs, being simple to operate, being easy to implement, and being suitable for industrial production. Experiments show that the emodin succinyl ester compound of the present invention may better promote the healing of diabetic wounds than emodin, and may be used for preparing a drug for promoting the healing of diabetic wounds.

Abstract: Disclosed in the present invention are an emodin succinyl ester compound, a preparation method therefor and a use thereof, the emodin succinyl ester compound having the structure as represented by formula I (R being a C1-5 alkyl group). The method provided in the present invention has a simple method course, and may effectively save time in synthesis and reduce costs, being simple to operate, being easy to implement, and being suitable for industrial production. Experiments show that the emodin succinyl ester compound of the present invention may better promote the healing of diabetic wounds than emodin, and may be used for preparing a drug for promoting the healing of diabetic wounds.

Abstract: The use of an HERG channel inhibitor for controlling the proliferation of cancer cells. Examples of such HERG channel inhibitors include dofetilide, cisapride, E-4031 and a siRNA molecule targeting a sequence involved in the expression of an HERG channel. Other ERG channels are also targets for these inhibitors.