Patents by Inventor Baogen Wu

Baogen Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterocyclic compounds and uses thereof
    Patent number: 12209102
    Abstract: The present disclosure provides compounds and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.
    Type: Grant
    Filed: May 17, 2024
    Date of Patent: January 28, 2025
    Assignee: Kumquat Biosciences Inc.
    Inventors: Pingda Ren, Liansheng Li, Baogen Wu, Xiaoming Li, Zhiyong Chen, Siling Zhao, Yi Liu, Xiuwen Zhu
  • Macrocyclic heterocycles and uses thereof
    Patent number: 12195465
    Abstract: The present disclosure provides compounds and pharmaceutically acceptable salt thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.
    Type: Grant
    Filed: October 30, 2023
    Date of Patent: January 14, 2025
    Assignee: Kumquat Biosciences Inc.
    Inventors: Baogen Wu, Pingda Ren, Zhiyong Chen, Yi Liu
  • HETEROCYCLIC COMPOUNDS AND USES THEREOF
    Publication number: 20240425522
    Abstract: The present disclosure provides compounds and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.
    Type: Application
    Filed: May 17, 2024
    Publication date: December 26, 2024
    Inventors: Pingda Ren, Liansheng Li, Baogen Wu, Xiaoming Li, Zhiyong Chen, Siling Zhao, Yi Liu, Xiuwen Zhu
  • HETEROCYCLIC COMPOUNDS AND USES THEREOF
    Publication number: 20240425525
    Abstract: The present disclosure provides compounds and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.
    Type: Application
    Filed: July 29, 2024
    Publication date: December 26, 2024
    Inventors: Pingda Ren, Liansheng Li, Baogen Wu, Xiaoming Li, Zhiyong Chen, Siling Zhao, Yi Liu, Xiuwen Zhu
  • HETEROCYCLIC COMPOUNDS AND USES THEREOF
    Publication number: 20240390389
    Abstract: The present disclosure provides compounds and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of certain oncogenic proteins.
    Type: Application
    Filed: April 12, 2024
    Publication date: November 28, 2024
    Inventors: Baogen Wu, Liansheng Li, Pingda Ren, Yi Liu, Siling Zhao, Xiaoming Li, Zhiyong Chen, Zhimin Zhu
  • HETEROCYCLIC COMPOUNDS AND USES THEREOF
    Publication number: 20240368191
    Abstract: The present disclosure provides compounds and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.
    Type: Application
    Filed: November 10, 2023
    Publication date: November 7, 2024
    Inventors: Xiaoming Li, Liansheng Li, Baogen Wu, Yuan Liu, Rasmus Hansen, Zhiyong Chen, Pingda Ren
  • MACROCYCLIC HETEROCYCLES AND USES THEREOF
    Publication number: 20240270736
    Abstract: The present disclosure provides compounds and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.
    Type: Application
    Filed: November 28, 2023
    Publication date: August 15, 2024
    Inventors: Baogen Wu, Liansheng Li, Pingda Ren, Zhiyong Chen, Siling Zhao, Xiuwen Zhu
  • Heterocyclic compounds and uses thereof
    Patent number: 12059425
    Abstract: The present disclosure provides compounds and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of certain oncogenic proteins.
    Type: Grant
    Filed: February 12, 2024
    Date of Patent: August 13, 2024
    Assignee: Kumquat Biosciences Inc.
    Inventors: Baogen Wu, Liansheng Li, Pingda Ren, Yi Liu, Siling Zhao, Xiaoming Li, Zhiyong Chen, Zhimin Zhu
  • HETEROCYCLIC COMPOUNDS AND USES THEREOF
    Publication number: 20240226113
    Abstract: The present disclosure provides compounds and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of certain oncogenic proteins.
    Type: Application
    Filed: February 12, 2024
    Publication date: July 11, 2024
    Inventors: Baogen Wu, Liansheng Li, Pingda Ren, Yi Liu, Siling Zhao, Xiaoming Li, Zhiyong Chen, Zhimin Zhu
  • MACROCYCLIC HETEROCYCLES AND USES THEREOF
    Publication number: 20240208975
    Abstract: The present disclosure provides compounds and pharmaceutically acceptable salt thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.
    Type: Application
    Filed: October 30, 2023
    Publication date: June 27, 2024
    Inventors: Baogen Wu, Pingda Ren, Zhiyong Chen, Yi Liu
  • HETEROCYCLIC COMPOUNDS AND USES THEREOF
    Publication number: 20240109918
    Abstract: The present disclosure provides compounds and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.
    Type: Application
    Filed: May 3, 2023
    Publication date: April 4, 2024
    Inventors: Xiaoming Li, Yuan Liu, Pingda Ren, Liansheng Li, Zhiyong Chen, Baogen Wu, Siling Zhao
  • Macrocyclic heterocycles and uses thereof
    Patent number: 11912708
    Abstract: The present disclosure provides compounds and pharmaceutically acceptable salt thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.
    Type: Grant
    Filed: June 2, 2023
    Date of Patent: February 27, 2024
    Assignee: KUMQUAT BIOSCIENCES INC.
    Inventors: Baogen Wu, Pingda Ren, Zhiyong Chen, Yi Liu
  • MACROCYCLIC HETEROCYCLES AND USES THEREOF
    Publication number: 20230339952
    Abstract: The present disclosure provides compounds and pharmaceutically acceptable salt thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.
    Type: Application
    Filed: June 2, 2023
    Publication date: October 26, 2023
    Inventors: Baogen Wu, Pingda Ren, Zhiyong Chen, Yi Liu
  • Substituted pyrido[2,3-d]pyrimidines as inhibitors of Ras pathway signaling
    Patent number: 11648254
    Abstract: The present disclosure provides compounds represented by Formula (I-1): and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.
    Type: Grant
    Filed: March 2, 2022
    Date of Patent: May 16, 2023
    Assignee: Kumquat Biosciences Inc.
    Inventors: Baogen Wu, Xiangzhu Wang, Xiaoming Li, Zhiyong Chen, Pingda Ren, Yi Liu
  • HETEROCYCLES AND USES THEREOF
    Publication number: 20230064360
    Abstract: The present disclosure provides compounds and pharmaceutically acceptable salt thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.
    Type: Application
    Filed: March 2, 2022
    Publication date: March 2, 2023
    Inventors: Baogen Wu, Xiangzhu Wang, Xiaoming Li, Zhiyong Chen, Pingda Ren, Yi Liu
  • N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE
    Publication number: 20220127247
    Abstract: The invention relates to heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.
    Type: Application
    Filed: February 4, 2020
    Publication date: April 28, 2022
    Inventors: Mihai AZIMIOARA, Bei CHEN, Robert EPPLE, James Paul LAJINESS, Casey Jacob Nelson MATHISON, Juliet NABAKKA, Victor Ivanovich NIKULIN, Sejal PATEL, Dean Paul PHILLIPS, Paul Vincent RUCKER, Andrew VALIERE, Baogen WU, Shanshan YAN, Xuefeng ZHU
  • MACROCYCLIC COMPOUNDS AND THEIR USE IN THE TREATMENT OF DISEASE
    Publication number: 20220071971
    Abstract: The invention relates to heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.
    Type: Application
    Filed: December 18, 2019
    Publication date: March 10, 2022
    Inventors: Mihai Azimioara, Badry Bursulaya, Songchun Jiang, Casey Jacob Nelson MATHISON, Victor Ivanovich NIKULIN, Truc Ngoc NGUYEN, Barun OKRAM, Sejal PATEL, Dean Paul PHILLIPS, Lewis WHITEHEAD, Baogen WU, Shanshan YAN, Xuefeng ZHU
  • N-(pyridin-2-ylsulfonyl)cyclopropanecarboxamide Derivatives and their Use in the Treatment of Disease
    Publication number: 20220033407
    Abstract: The invention relates to heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.
    Type: Application
    Filed: December 13, 2019
    Publication date: February 3, 2022
    Inventors: Mihai D. Azimioara, Bei Chen, Robert Epple, Declan Hardy, Ayako Honda, Philip Lam, Hasnain Ahmed Malik, Fabio Meier, Truc Ngoc Nguyen, Barun Okram, Sejal Patel, Rodrigo Rodriguez, Duncan Shaw, Yiping Shen, Baogen WU
  • N-(pyridin-2-yl)pyridine-sulfonamide derivatives and their use in the treatment of disease
    Patent number: 11066369
    Abstract: The invention relates to heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.
    Type: Grant
    Filed: September 10, 2019
    Date of Patent: July 20, 2021
    Assignee: Novartis AG
    Inventors: Mihai Azimioara, Bei Chen, Robert Epple, Ayako Honda, Philip Lam, Hasnain Ahmed Malik, Casey Jacob Nelson Mathison, True Ngoc Nguyen, Victor Ivanovich Nikulin, Sejal Patel, Dean Paul Phillips, Rodrigo A. Rodriguez, Baogen Wu, Xuefeng Zhu
  • N-(pyridin-2-yl)pyridine-sulfonamide Derivatives and their Use in the Treatment of Disease
    Publication number: 20200002281
    Abstract: The invention relates to heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.
    Type: Application
    Filed: September 10, 2019
    Publication date: January 2, 2020
    Inventors: Mihai Azimioara, Bei Chen, Robert Epple, Ayako Honda, Philip Lam, Hasnain Ahmed Malik, Casey Jacob Nelson Mathison, Truc Ngoc Nguyen, Victor Ivanovich Nikulin, Sejal Patel, Dean Paul Phillips, Rodrigo A. Rodriguez, Baogen Wu, Xuefeng Zhu