Patents by Inventor Baoguo Zhu

Baoguo Zhu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for determining glycosylation and terminal modification of samples during protein purification process
    Patent number: 9645156
    Abstract: The present invention provides a method for determining glycosylation and terminal modifications of immunoglobulin during immunoglobulin purification process, which can simultaneously and rapidly determine glycosylation, N-terminal pyroglutamination and C-terminal de-lysination of immunoglobulin, including Step 1) separating immunoglobulin by using cation-exchange resin, and collecting different components in according to retention time; Step 2) denaturing the components of immunoglobulin obtained in step 1) with a denaturant, followed by reducing them with a reducing agent, to separate the light chain and heavy chain; Step 3) separating the light chain and heavy chain of immunoglobulin of step 2) by using reverse phase ultrahigh pressure liquid chromatography; Step 4) measuring the molecular weights of the light chain and heavy chain obtained in step 3) with mass spectrum; and Step 5) analyzing the chromatographic data obtained in step 3) and the mass spectrometric data obtained in step 4) to determine glyco
    Type: Grant
    Filed: April 24, 2013
    Date of Patent: May 9, 2017
    Assignee: LIVZON MABPHARM INC.
    Inventors: Baoguo Zhu, Yucai Peng, Jiaming Yang
  • A METHOD FOR DETERMINING GLYCOSYLATION AND TERMINAL MODIFICATION OF SAMPLES DURING PROTEIN PURIFICATION PROCESS
    Publication number: 20150362506
    Abstract: The present invention provides a method for determining glycosylation and terminal modifications of immunoglobulin during immunoglobulin purification process, which can simultaneously and rapidly determine glycosylation, N-terminal pyroglutamination and C-terminal de-lysination of immunoglobulin.
    Type: Application
    Filed: April 24, 2013
    Publication date: December 17, 2015
    Inventors: Baoguo ZHU, Yucai PENG, Jiaming YANG
  • Humanized anti-TNF? antibodies
    Patent number: 8658171
    Abstract: The present invention provides a humanized anti-TNF monoclonal antibody and the use thereof. The humanized anti-TNF monoclonal antibody significantly reduces the immunogenicity of murine-antibody while retaining the ability of antibody to recognize antigen, compared with conservative mouse chimeric antibody. Therefore, safety of the antibody in clinical applications has been improved.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: February 25, 2014
    Assignee: Livzon Mabpharm Inc.
    Inventors: Baoguo Zhu, Desheng Tao, Bill Nai-Chau Sun, Lee-Hwei King Sun, Ruey Shyan Liou, Cecily Rou-Yun Sun, Qiang Li, Yucai Peng, Jingwei Zhang, Zhenxiang Hu
  • Humanized Anti-TNFalpha Antibodies
    Publication number: 20120219547
    Abstract: The present invention provides a humanized anti-TNF monoclonal antibody and the use thereof. The humanized anti-TNF monoclonal antibody significantly reduces the immunogenicity of murine-antibody while retaining the ability of antibody to recognize antigen, compared with conservative mouse chimeric antibody. Therefore, safety of the antibody in clinical applications has been improved.
    Type: Application
    Filed: February 24, 2012
    Publication date: August 30, 2012
    Inventors: Baoguo Zhu, Desheng Tao, Bill Nai-Chau Sun, Lee-Hwei King Sun, Ruey Shyan Liou, Cecily Rou-Yun Sun, Qiang Li, Yucai Peng, Jingwei Zhang, Zhenxiang Hu
  • Storage bag
    Patent number: D1021638
    Type: Grant
    Filed: December 29, 2023
    Date of Patent: April 9, 2024
    Inventor: Baoguo Zhu