Abstract: A display panel is provided. The display panel includes a first substrate, a second substrate, and a liquid crystal layer. The liquid crystal layer includes multiple liquid crystal molecules. The display panel includes multiple primary spacer assemblies, and each of the multiple the primary spacer assemblies includes a first primary spacer, a second primary spacer, and a piezoelectric element. The first primary spacer is adjacent to the second primary spacer, and two opposite ends of the piezoelectric element are respectively connected to the first primary spacer and the second primary spacer.

Abstract: A display panel is provided. The display panel includes a display region and a non-display region surrounding a periphery of the display region. The non-display region includes a multiple corner regions and multiple linear regions. The display panel further includes a first substrate, a second substrate, a liquid crystal layer, and a bezel assembly. The bezel assembly includes multiple support members and multiple sealant. At least one of the multiple support members is disposed in the corner region and the sealant is disposed in the linear region. The support member and the sealant bonds the first substrate and the second substrate. Two opposite ends of the sealant are respectively connected with one of the support members in two corner regions, and the liquid crystal layer is sealed between the first substrate and the second substrate. A display device having the display panel is also provided.

Abstract: The present disclosure discloses a method for expressing and preparing a bivalent bispecific antibody. In the present disclosure, each portion of a bivalent bispecific antibody and an immune hybrid protein thereof is respectively expressed in a suitable prokaryotic or eukaryotic cell system, separated and purified by high-performance affinity chromatography, and then spliced in vitro by trans-splicing reaction mediated by an intein, to prepare the bivalent specific antibody and an immune hybrid protein thereof.

Abstract: The present invention relates to stable and high-producing site-specific integration (SSI) host cells, e. g. Chinese hamster ovary (CHO)-derived host cells, methods to produce and to use them.

Abstract: The present disclosure relates to the field of biological technologies, and discloses a method for expressing and preparing a polyvalent multi-specific antibody and an immune hybrid protein. By using the characteristics of protein Intein, a novel method for preparing a polyvalent specific antibody, a hybrid immune protein having an antibody fused to a cytokine, an immunotoxin having an antibody fused to a toxin, or an immune hybrid protein having an antibody fused to other active proteins is designed and developed. Each portion of a hybrid protein is respectively expressed in a suitable prokaryotic or eukaryotic cell system, separated and purified by high-performance affinity chromatography, and then spliced in vitro by trans-splicing mediated by the intein, to prepare a polyvalent specific antibody and an immune hybrid protein. The method has high production efficiency, and wide scope of application, and facilitates the separation and purification of the products.

Abstract: The present invention relates to stable and high-producing site-specific integration (SSI) host cells, e. g. Chinese hamster ovary (CHO)-derived host cells, methods to produce and to use them.

Abstract: The present invention relates to stable and high-producing site-specific integration (SSI) host cells, e. g. Chinese hamster ovary (CHO)-derived host cells, methods to produce and to use them.

Abstract: The present disclosure relates to the field of biological technologies, and discloses a method for expressing and preparing a bivalent bispecific antibody. In the present disclosure, each portion of a bivalent bispecific antibody and an immune hybrid protein thereof is respectively expressed in a suitable prokaryotic or eukaryotic cell system, separated and purified by high-performance affinity chromatography, and then spliced in vitro by trans-splicing reaction mediated by an intein, to prepare the bivalent specific antibody and an immune hybrid protein thereof. The method has high production efficiency and wide scope of application, and facilitates the separation and purification of the products. The product prepared through the present method has bivalent bispecific immune affinity and cytotoxic bioactivity. Therefore, the present disclosure provides a novel method for preparing biological drugs for directionally attacking cancers or other diseases.

Abstract: The present invention relates to stable and high-producing site-specific integration (SSI) host cells, e.g. Chinese hamster ovary (CHO)-derived host cells, methods to produce and to use them.