Patents by Inventor Baolian Li

Baolian Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11666911
    Abstract: A sample extraction chip and a biological reaction device are disclosed according to the present disclosure. The sample extraction chip includes a chip body and a sample extraction module provided on the chip body, the sample extraction module includes a sample-loading lysis unit, a liquid release-control unit, an extraction unit, a liquid switch-control unit, a liquid collection unit and a sample collection unit, which are connected through flow channels in a sequence of extraction. The liquid release-control unit is configured to store and release liquid reagents, and the liquid switch-control unit is configured to switch between communication of the liquid collection unit and the extraction unit and communication of the sample collection unit and the extraction unit. The sample collection unit includes a front collection portion and a rear collection portion which are both in communication with the liquid switch-control unit.
    Type: Grant
    Filed: December 14, 2020
    Date of Patent: June 6, 2023
    Assignee: Capitalbio Corporation
    Inventors: Longtang Zheng, Lei Wang, Liang Bai, Xinying Zhou, Fei Wen, Yanan Wang, Xiang Chen, Tengfei Guo, Baolian Li, Li Ma, Jing Cheng
  • Patent number: 11577240
    Abstract: A liquid storage and controlled-release device and a biological detection chip. The liquid storage and controlled-release device comprises a liquid storage capsule with a liquid storage body which is deformable under a pressure, and a sealing layer for sealing the liquid storage body. A support platform is provided right below the liquid storage capsule and tightly connected with the liquid storage capsule, wherein, a directional release chamber is provided at the middle of the support platform, and the directional release chamber is provided with a guiding chamber for collecting the liquid and a sharp edge for inducing break. Compared with the conventional technology, the opening for liquid release is at the end far away from the rotation center, so that the liquid can be released completely by the centrifugal force, ensuring the quantitative release of stored liquid and reducing the influence on the accuracy of the subsequent detection.
    Type: Grant
    Filed: February 3, 2021
    Date of Patent: February 14, 2023
    Assignees: Capitalbio Corporation, West China Hospital of Sichuan University
    Inventors: Xinying Zhou, Lei Wang, Liang Bai, Tengfei Guo, Shuo Li, Baolian Li, Bin Zhuang, Xiang Chen, Hongju Guo, Xiaolei Zhao, Wanli Xing, Jing Cheng
  • Patent number: 11565255
    Abstract: A valve system for driving fluid and a method for using the same are provided. The valve system includes a fluid unit far away from the rotation center, a fluid unit close to the rotation center, a fluid transferring unit and a gas path pipeline for communicating the fluid unit close to the rotation center with the fluid unit far away from the rotation center. A rotation radius of a fluid outlet of the fluid unit far away from the rotation center is greater than that of a fluid inlet of the fluid unit close to the rotation center. The fluid outlet of the fluid unit far away from the rotation center is located at an end thereof away from the rotation center, and the fluid inlet of the fluid unit close to the rotation center is located at an end thereof close to the rotation center.
    Type: Grant
    Filed: February 5, 2021
    Date of Patent: January 31, 2023
    Assignees: Capitalbio Corporation, West China Hospital of Sichuan University
    Inventors: Liang Bai, Tengfei Guo, Lei Wang, Xinying Zhou, Juan Xin, Baolian Li, Li Ma, Libing Dong, Jing Cheng
  • Publication number: 20210322979
    Abstract: A liquid storage and controlled-release device and a biological detection chip. The liquid storage and controlled-release device comprises a liquid storage capsule with a liquid storage body which is deformable under a pressure, and a sealing layer for sealing the liquid storage body. A support platform is provided right below the liquid storage capsule and tightly connected with the liquid storage capsule, wherein, a directional release chamber is provided at the middle of the support platform, and the directional release chamber is provided with a guiding chamber for collecting the liquid and a sharp edge for inducing break. Compared with the conventional technology, the opening for liquid release is at the end far away from the rotation center, so that the liquid can be released completely by the centrifugal force, ensuring the quantitative release of stored liquid and reducing the influence on the accuracy of the subsequent detection.
    Type: Application
    Filed: February 3, 2021
    Publication date: October 21, 2021
    Inventors: Xinying Zhou, Lei Wang, Liang Bai, Tengfei Guo, Shuo Li, Baolian Li, Bin Zhuang, Xiang Chen, Hongju Guo, Xiaolei Zhao, Wanli Xing, Jing Cheng
  • Publication number: 20210322980
    Abstract: A whole-process biological detection device is provided. The whole-process biological detection device belongs to the technical field of biological detection, and includes at least one reactor, where the reactor includes at least one sample-loading unit, at least one liquid release-control unit, at least one extraction unit, at least one liquid switch-control unit, at least one liquid collection unit, at least one liquid transfer unit, at least one liquid flow-control unit, at least one liquid quantitative dispersion unit and multiple reaction cells. The product of the solution has the characteristics of high integration, no need for additional reagents, simple operation, stable and reliable, etc., thereby achieving the goal of sealing the whole process of biological detection and effectively avoiding cross-contamination between samples and equipment.
    Type: Application
    Filed: March 1, 2021
    Publication date: October 21, 2021
    Inventors: Lei WANG, Liang BAI, Xiang CHEN, Tengfei GUO, Xinying ZHOU, Jing CHENG, Fei WEN, Yanan WANG, Longtang ZHENG, Peng LIU, Baolian LI, Youchun XU, Bin ZHUANG, Wanli XING
  • Publication number: 20210322983
    Abstract: A valve system for driving fluid and a method for using the same are provided. The valve system includes a fluid unit far away from the rotation center, a fluid unit close to the rotation center, a fluid transferring unit and a gas path pipeline for communicating the fluid unit close to the rotation center with the fluid unit far away from the rotation center. A rotation radius of a fluid outlet of the fluid unit far away from the rotation center is greater than that of a fluid inlet of the fluid unit close to the rotation center. The fluid outlet of the fluid unit far away from the rotation center is located at an end thereof away from the rotation center, and the fluid inlet of the fluid unit close to the rotation center is located at an end thereof close to the rotation center.
    Type: Application
    Filed: February 5, 2021
    Publication date: October 21, 2021
    Inventors: Liang Bai, Tengfei Guo, Lei Wang, Xinying Zhou, Juan Xin, Baolian Li, Li Ma, Libing Dong, Jing Cheng
  • Publication number: 20210322982
    Abstract: A sample extraction chip and a biological reaction device are disclosed according to the present disclosure. The sample extraction chip includes a chip body and a sample extraction module provided on the chip body, the sample extraction module includes a sample-loading lysis unit, a liquid release-control unit, an extraction unit, a liquid switch-control unit, a liquid collection unit and a sample collection unit, which are connected through flow channels in a sequence of extraction. The liquid release-control unit is configured to store and release liquid reagents, and the liquid switch-control unit is configured to switch between communication of the liquid collection unit and the extraction unit and communication of the sample collection unit and the extraction unit. The sample collection unit includes a front collection portion and a rear collection portion which are both in communication with the liquid switch-control unit.
    Type: Application
    Filed: December 14, 2020
    Publication date: October 21, 2021
    Inventors: Longtang Zheng, Lei Wang, Liang Bai, Xinying Zhou, Fei Wen, Yanan Wang, Xiang Chen, Tengfei Guo, Baolian Li, Li Ma, Jing Cheng