Abstract: A magnetic resonance (MR) generating a static (BO) magnetic field of 5 Tesla or higher controller is configured to control an MR scanner to perform an MR sequence (14) including: performing an excitation/localization sub-sequence (30) on a subject disposed in the static (BO) magnetic field generated by the MR scanner to excite 1H polarization in a selected spatial region of the subject; performing 5 a polarization transfer sub-sequence (32) to transfer localized 1H polarization generated by the excitation/localization sub-sequence to a selected species of non-proton nuclei; and performing a magnetic resonance spectroscopy (MRS) readout sub-sequence (40) to acquire MRS data for the selected species of non-proton nuclei in the selected spatial region of the subject. The polarization transfer sub-sequence includes a pair of phase 10 distortion canceling trapezoidal 180° refocusing pulses (36, 37) operating on the selected species of non-proton nuclei.

Abstract: A magnetic resonance (MR) sequence (14) is performed, including: applying a preparatory MR sub-sequence (S prep) providing water signal suppression; performing a magnetic resonance spectroscopy (MRS) sub-sequence (S MRS) after applying the preparatory MR sub-sequence to acquire H MRS data with water signal suppression; and performing an MR reference sub-sequence (S Ref) to acquire MR reference data. The MR reference sub-sequence is performed after the MRS sub-sequence. Phase and B0 correction of the H MRS data with water signal suppression are performed using the MR reference data to generate corrected MRS data. The excitation pulse (g) of the MR reference sub-sequence has a flip angle of less than or equal to o, and more preferably has a flip angle of less than or equal to 3 o. In some embodiments the MR sequence has a total repetition time (TR) of 2000 msec or less.

Abstract: A magnetic resonance imaging (MRI) system (600), for acquiring magnetic resonance (MR) information of a volume, includes at least one controller (610) configured generate at least a portion of a stimulated echo acquisition mode (STEAM) CEST-sequence including first through third 90° radio frequency (RF) pulses, and a first pulse train situated before the first 90° RF pulse. The first pulse train has first number of pulses. The controller (610) is further configured to generate at least another portion of the STEAM CEST sequence comprising a second pulse train situated between the second and third 90° RF pulses, the second pulse train comprising a second number of pulses which is less than the first number of pulses; generating end of spoil gradients; and/or to ac quire MR information during an acquisition window which is stated at least partially after the end of spoil gradients.

Abstract: A magnetic resonance (MR) system for detecting concentrations of one or more metabolites in a volume of interest (VOI), the system including at least one controller which: may apply to the VOI a multiple quantum filter (MQF) Point Resolved Spetroscopy (PRESS) sequence comprising first and second 90° RF pulses, a third 90° RF pulse, first and second 180° adiabatic pulses, and a composite dual-band delay alternating with nutation for tailored excitation (DANTE) pulse train having a plurality of N block pulses (N being an integer), the DANTE pulse train situated in time between the first and second 90° RF pulses, the first and second 180° adiabatic pulses situated in time after third 90° RF pulse; detect MR Free Induced Decay (FID) signal emitted from the VOI; and/or reconstruct the detected MR FID signal to obtain metabolite spectrum information.

Abstract: A magnetic resonance (MR) sequence (14) is performed, including: applying a preparatory MR sub-sequence (S prep) providing water signal suppression; performing a magnetic resonance spectroscopy (MRS) sub-sequence (S MRS) after applying the preparatory MR sub-sequence to acquire H MRS data with water signal suppression; and performing an MR reference sub-sequence (S Ref) to acquire MR reference data. The MR reference sub-sequence is performed after the MRS sub-sequence. Phase and B0 correction of the H MRS data with water signal suppression are performed using the MR reference data to generate corrected MRS data. The excitation pulse (g) of the MR reference sub-sequence has a flip angle of less than or equal to o, and more preferably has a flip angle of less than or equal to 3 o. In some embodiments the MR sequence has a total repetition time (TR) of 2000 msec or less.

Abstract: A magnetic resonance (MR) generating a static (BO) magnetic field of 5 Tesla or higher controller is configured to control an MR scanner to perform an MR sequence (14) including: performing an excitation/localization sub-sequence (30) on a subject disposed in the static (BO) magnetic field generated by the MR scanner to excite 1H polarization in a selected spatial region of the subject; performing 5 a polarization transfer sub-sequence (32) to transfer localized 1H polarization generated by the excitation/localization sub-sequence to a selected species of non-proton nuclei; and performing a magnetic resonance spectroscopy (MRS) readout sub-sequence (40) to acquire MRS data for the selected species of non-proton nuclei in the selected spatial region of the subject. The polarization transfer sub-sequence includes a pair of phase 10 distortion canceling trapezoidal 180° refocusing pulses (36, 37) operating on the selected species of non-proton nuclei.