Patents by Inventor Baoxian Zhang

Baoxian Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12264146
    Abstract: Provided are a Rho kinase inhibitor, a method for preparing same and the uses thereof. The Rho kinase inhibitor designates a compound of Formula I, a stereoisomer thereof or pharmaceutically acceptable salt thereof. The Rho kinase inhibitor promotes endothelial cells and endothelin expression, prostenin expression, and vascular factors NO synthesis and secretion, has a promoting effect on proprostin expression independently of the doses used, shows lower toxicity, while being safer.
    Type: Grant
    Filed: May 6, 2019
    Date of Patent: April 1, 2025
    Assignee: Beijing Increase Innovative Drug Co., LTD
    Inventors: Baoxian Zhang, Hongwu Zhang, Jie Hu, Zhiyun Kang, Chunmei Xue, Wenhui Li, Yanwei Song, Zhenzhen Wu, Anping Chen, Fang Wang, Hengchun Ren, Jun Li
  • Publication number: 20220313683
    Abstract: A brucine gel formulation, a preparation method therefor and use thereof. Said gel formulation comprises 0.5%-1% of brucine, 0.5%-3% of a gel matrix and 10%-30% of a co-solvent. Said brucine hydrogel does not contain a transdermal enhancer, but has an excellent transdermal effect, is easy to coat, has good biosolubility, good skin absorption and good drug film adhesion, and is non-irritating to the skin and mucosa.
    Type: Application
    Filed: July 31, 2020
    Publication date: October 6, 2022
    Inventors: Baoxian ZHANG, Jie HU, Zhenzhen WU, Qian ZHAO, Chunmei XUE, Wenhui LI, Ying CAO
  • Publication number: 20220002265
    Abstract: Provided are a Rho kinase inhibitor, a method for preparing same and the uses thereof. The Rho kinase inhibitor designates a compound of Formula I, a stereoisomer thereof or pharmaceutically acceptable salt thereof. The Rho kinase inhibitor promotes endothelial cells and endothelin expression, prostenin expression, and vascular factors NO synthesis and secretion, has a promoting effect on proprostin expression independently of the doses used, shows lower toxicity, while being safer.
    Type: Application
    Filed: May 6, 2019
    Publication date: January 6, 2022
    Inventors: Baoxian ZHANG, Hongwu ZHANG, Jie HU, Zhiyun KANG, Chunmei XUE, Wenhui LI, Yanwei SONG, Zhenzhen WU, Anping CHEN, Fang WANG, Hengchun REN, Jun LI
  • Publication number: 20200316003
    Abstract: Disclosed are a fudosteine solution preparation for aerosol inhalation, and a preparation method therefor. The fudosteine solution preparation for aerosol inhalation comprises fudosteine, salts thereof and/or hydrates thereof; a metal complexing agent; and water for injection.
    Type: Application
    Filed: June 17, 2020
    Publication date: October 8, 2020
    Applicant: Beijing Increase Innovation Drug Research Co., LTD
    Inventors: Baoxian Zhang, Jie Hu
  • Publication number: 20200261362
    Abstract: The present disclosure provides a solution preparation for aerosol inhalation of carbocisteine, and a preparation method therefor. The solution preparation for aerosol inhalation of carbocisteine of the present disclosure comprises carbocisteine, a salt thereof and/or a hydrate thereof, a metal complexing agent, a pH adjusting agent, and water for injection. The solution preparation for aerosol inhalation of carbocisteine of the present disclosure has the characteristics of high efficiency, low toxicity, good stability and high safety, and particularly, greatly reduces the hepatotoxicity and the renal toxicity to patients using the drug.
    Type: Application
    Filed: May 7, 2020
    Publication date: August 20, 2020
    Applicant: Beijing Increase Innovation Drug Research Co., LTD
    Inventors: Baoxian ZHANG, Jie HU
  • Publication number: 20120093087
    Abstract: A method, apparatus, and computer program product are provided for routing data packets through a wireless sensor network to a mobile sink in a relatively quick and efficient manner while utilizing low protocol overhead. Additionally, a method, apparatus, and computer program product are provided such that a sensor node within a wireless sensor network maintains sink information and routing information to facilitate efficient delivery of a data packet to a mobile sink within a wireless sensor network.
    Type: Application
    Filed: June 29, 2009
    Publication date: April 19, 2012
    Applicant: NOKIA CORPORATION
    Inventors: Canfeng Chen, Jian Ma, Baoxian Zhang