Patents by Inventor Baoxiang WANG

Baoxiang WANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tetramaleimide linkers and use thereof
    Patent number: 11666623
    Abstract: The present invention is directed to tetramaleimide linkers and use thereof, more specifically to the compounds represented by formula I and their use in the preparation of antibody-drug conjugates (ADCs). The ADCs obtained from the tetramaleimide linkers have high homogeneity and stability, and could be used effectively for the treatment of various diseases including tumors. The definition of the groups in formula I is the same as that in the description.
    Type: Grant
    Filed: April 18, 2018
    Date of Patent: June 6, 2023
    Assignee: NewBio Therapeutics, Inc.
    Inventors: Deqiang An, Nianhe Han, Peng Zhu, Di Zeng, Baoxiang Wang, Huali Li, Chun Yang
  • Oxadiazole linkers and use thereof
    Patent number: 11241503
    Abstract: The present invention is directed to oxadiazole linkers and use thereof, more specifically to the compounds represented by formula I, II, and III, and their use in the preparation of antibody-drug conjugates (ADCs). The ADCs obtained from said oxadiazole linkers have high homogeneity and stability, and could be used effectively for the treatment of various diseases including tumors. The definition of the groups in formula I, II, and III is the same as that in the description.
    Type: Grant
    Filed: June 4, 2018
    Date of Patent: February 8, 2022
    Assignee: NewBio Therapeutics, Inc.
    Inventors: Nianhe Han, Deqiang An, Di Zeng, Baoxiang Wang, Huali Li, Hang Chen, Chun Yang
  • OXADIAZOLE LINKERS AND USE THEREOF
    Publication number: 20210154320
    Abstract: The present invention is directed to oxadiazole linkers and use thereof, more specifically to the compounds represented by formula I, II, and III, and their use in the preparation of antibody-drug conjugates (ADCs). The ADCs obtained from said oxadiazole linkers have high homogeneity and stability, and could be used effectively for the treatment of various diseases including tumors. The definition of the groups in formula I, II, and III is the same as that in the description.
    Type: Application
    Filed: June 4, 2018
    Publication date: May 27, 2021
    Inventors: Nianhe HAN, Deqiang AN, Di ZENG, Baoxiang WANG, Huali LI, Hang CHEN, Chun YANG
  • TETRAMALEIMIDE LINKERS AND USE THEREOF
    Publication number: 20210128668
    Abstract: The present invention is directed to tetramaleimide linkers and use thereof, more specifically to the compounds represented by formula I and their use in the preparation of antibody-drug conjugates (ADCs). The ADCs obtained from the tetramaleimide linkers have high homogeneity and stability, and could be used effectively for the treatment of various diseases including tumors. The definition of the groups in formula I is the same as that in the description.
    Type: Application
    Filed: April 18, 2018
    Publication date: May 6, 2021
    Inventors: Deqiang AN, Nianhe HAN, Peng ZHU, DI ZENG, Baoxiang WANG, Huali LI, Chun YANG
  • Trimaleimide linkers and uses thereof
    Patent number: 10314922
    Abstract: A type of trimaleimide linkers and uses thereof are disclosed. The trimaleimide linkers can be applied for preparation of antibody-drug conjugate as shown by formula I: L-(T-A-D)n I wherein, L is an antibody, antibody fragment or protein; T is a trimaleimide linker; A is a cleavable linker group or a noncleavable linker; D is a drug; n is an integer ranging from 1 to 8.
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: June 11, 2019
    Assignee: NewBio Therapeutics, Inc.
    Inventors: Nianhe Han, Deqiang An, Di Zeng, Baoxiang Wang, Hang Yang, Li Jian, Chun Yang
  • Trimaleimide Linkers and Uses Thereof
    Publication number: 20180147295
    Abstract: A type of trimaleimide linkers and uses thereof are disclosed. The trimaleimide linkers can be applied for preparation of antibody-drug conjugate as shown by formula I: L-(T-A-D)nI wherein, L is an antibody, antibody fragment or protein; T is a trimaleimide linker; A is a cleavable linker group or a noncleavable linker; D is a drug; n is an integer ranging from 1 to 8.
    Type: Application
    Filed: May 17, 2016
    Publication date: May 31, 2018
    Inventors: Nianhe HAN, Deqiang AN, Di ZENG, Baoxiang WANG, Hang YANG, Li JIAN, Chun YANG