Abstract: Disclosed is a linoleic acid derivative of Formula (I) below including a hydrophobic part C17H31 linked to a polar head part “A”: wherein the polar head part A is selected from A1 to A4 below: or a pharmaceutically/food quality acceptable salt thereof.

Abstract: The present invention provides novel compounds of formula (I) and pharmaceutical compositions containing these compounds. The compounds of formula (I) can act as PAR-2 inhibitors, which renders these compounds highly advantageous for use in therapy, particularly in the treatment or prevention of pain, an autoimmune disorder, an autoinflammatory disorder, an inflammatory disorder, a central nervous system disorder, spinal cord injury, a metabolic disorder, a gastrointestinal disorder, a cardiovascular disorder, a fibrotic disorder, a respiratory disorder, a skin disorder, an allergic disorder, or cancer.

Abstract: Disclosed is a linoleic acid derivative of Formula (I) below including a hydrophobic part C17H31 linked to a polar head part “A”: wherein the polar head part A is selected from A1 to A4 below: or a pharmaceutically/food quality acceptable salt thereof.