Abstract: An adapter (50) for achieving intradennal dosed delivery of a liquid by use of a dosed drug delivery device including a reservoir having a pierceable septum, the adapter having a connector including an attachment configuration (22) for sliding a recess of the adapter onto a projection of the dosed drug delivery device and a hollow needle (25) deployed for piercing the septum. At least one microneedle (10) projects from the connector. A flow path arrangement (28) interconnects the needle and the hollow microneedle(s). The recess is shaped to restrict the microneedle(s) to only a finite number of rotational orientations relative to the axis of the device. The connector and/or the needle is adapted for application of a sealant to prevent leakage of the liquid.

Abstract: An injection system applicable to off-the-shelf syringes having a microneedle hub may reduce dead space and isolate the drug fluid from the microneedle chip to avoid compatibility issues. An insert may be disposed inside a male luer fitting and extend so that it is also disposed inside the female luer fitting using an insert. A septum may isolate the drug fluid from the microneedle chip in the hub prior to activation and the septum may, after activation, seal the triangular space in the hub to prevent leakage of fluid back to the syringe.