Patents by Inventor Barbara A. Azzolina

Barbara A. Azzolina has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MurC gene and enzyme of
    Patent number: 7022829
    Abstract: This invention provides isolated polynucleotides that encode the MurC protein of Pseudomonas aeruginosa. Purified and isolated MurC recombinant proteins are also provided. Nucleic acid sequences which encode functionally active MurC proteins are described. Assays for the identification of modulators of the of expression of murC and inhibitors of the activity of MurC, are also provided.
    Type: Grant
    Filed: September 11, 2000
    Date of Patent: April 4, 2006
    Assignee: Merck & Co., Inc.
    Inventors: Mohamend El-Sherbeini, Barbara Azzolina
  • Murf gene and enzyme of Pseudomonas aeruginosa
    Patent number: 6949336
    Abstract: This invention provides isolated polynucleotides that encode the MurF (UDP-N-acetylmuramyl-L-alanine-D-glutamate-m-DaD:D-alanine-D-alanine ligase) protein of Pseudomonas aeruginosa. Purified and isolated MurF recombinant proteins are also provided. Nucleic acid sequences which encode functionally active MurF proteins are described. Assays for the identification of modulators of the expression of murF and inhibitors of the activity of MurF, are also provided.
    Type: Grant
    Filed: September 6, 2000
    Date of Patent: September 27, 2005
    Assignee: Merck & Co., Inc.
    Inventors: Mohamend El-Sherbeini, Barbara Azzolina
  • Murd protein and gene of Pseudomonas aeruginosa
    Patent number: 6890910
    Abstract: This invention provides isolated polynucleotides that encode the MurD protein of Pseudomonas aeruginosa. Purified and isolated MurD recombinant proteins are also provided. Nucleic acid sequences which encode functionally active MurD proteins are described. Assays for the identification of modulators of the of expression of murD and inhibitors of the activity of MurD, are also provided.
    Type: Grant
    Filed: May 26, 1999
    Date of Patent: May 10, 2005
    Assignee: Merck & Co., Inc.
    Inventors: Mohammed El-Sherbeini, Barbara Azzolina
  • MurE protein and gene of pseudomonas aeruginosa
    Patent number: 6870041
    Abstract: This invention provides isolated polynucleotides that encode the MurE protein of Pseudomonas aeruginosa. Purified and isolated MurE recombinant proteins are also provided. Nucleic acid sequences which encode functionally active MurE proteins are described. Assays for the identification of modulators of the of expression of murE and inhibitors of the activity of MurE, are also provided.
    Type: Grant
    Filed: September 11, 2000
    Date of Patent: March 22, 2005
    Assignee: Merck & Co., Inc.
    Inventors: Mohamend El-Sherbeini, Barbara Azzolina
  • MraY gene and enzyme of pseudomonas aeruginosa
    Patent number: 6861516
    Abstract: Polynucleotides and polypeptides of Pseudomonas aeruginosa MraY, an enzyme involved in bacterial cell wall biosynthesis, are provided. The recombinant MraY enzyme is catalytically active in the first step of the membrane cycle of peptidoglycan biosynthesis. Also provided are proteins encoded by the sequences, host cells expressing the recombinant enzyme, and probes and primers.
    Type: Grant
    Filed: September 29, 2000
    Date of Patent: March 1, 2005
    Assignee: Merck & Co., Inc.
    Inventors: Mohamed El-Sherbeini, Barbara A. Azzolina
  • 5-Amino or substituted amino 1,2,3,-triazoles useful as antiproliferative agents
    Patent number: 4847257
    Abstract: 5-Amino or substituted amino 1,2,3-triazoles are disclosed as a new class of antiproliferative agents useful in the treating and managing of psoriasis, inflammatory bowel syndrome, cutaneous leishmanilisis and certain types of cancer.
    Type: Grant
    Filed: August 20, 1987
    Date of Patent: July 11, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Donald Hupe, Lawrence Argenbright, Nancy Behrens, Barbara A. Azzolina