Abstract: Attenuated Toxoplasma gondii mutants and methods using the same as vaccines in the prevention or treatment pancreatic cancer are provided.

Abstract: The present invention provides attenuated Toxoplasma gondii mutants for use as vaccines in the prevention or treatment of cancer.

Abstract: Attenuated Toxoplasma gondii mutants and methods using the same as vaccines in the prevention or treatment pancreatic cancer are provided.

Abstract: Uracil auxotroph mutants of apicomplexans are provided which lack a functional carbamoyl phosphate synthase II (CPSII) enzyme. Also provided are T. gondii autoxtroph mutants which express exogenous antigens, and methods of protecting an animal against a T. gondii and non-T. gondii disease.

Abstract: The present invention provides attenuated Toxoplasma gondii knockout mutants of the de novo pyrimidine synthesis pathway and use of the same in vaccines and methods of providing an immune response and protecting a subject against infection by T. gondii and a non-T. gondii disease.

Abstract: The present invention provides attenuated Toxoplasma gondii mutants for use as vaccines in the prevention or treatment of cancer.

Abstract: The present invention relates to a mutant Toxoplasma gondii which exhibits enhanced homologous recombination. The mutant of the present invention is a knockout in the KU80-dependent nonhomologous end-joining pathway which finds application in generating T. gondii gene knockouts and gene replacements for use in vaccine and drug development.

Abstract: The present invention provides attenuated Toxoplasma gondii knockout mutants of the de novo pyrimidine synthesis pathway and use of the same in vaccines and methods of providing an immune response and protecting a subject against infection by T. gondii and a non-T. gondii disease.

Abstract: The present invention relates to a mutant Toxoplasma gondii which exhibits enhanced homologous recombination. The mutant of the present invention is a knockout in the KU80-dependent nonhomologous end-joining pathway which finds application in generating T. gondii gene knockouts and gene replacements for use in vaccine and drug development.

Abstract: A distributed software redundancy design is disclosed to minimize network outages and other problems associated with component/process failures by spreading software backup (in the so-called “hot state”) across multiple elements. The distributed redundancy architecture of the present invention also permits the location of the hardware backup element to float, that is, if a primary element fails, the functions can be transferred over to the backup element. When the failed primary element is replaced, the replacement hardware can serve as the hardware backup. If one or more of the primary processes on a particular element experiences a software fault, the processor on the line card may terminate and restart the failing process or processes. Once the process or processes are restarted, a copy of the last known dynamic state (i.e.

Abstract: The invention provides a method for fault isolation in a computer system, such as a network device. The method calls for providing a plurality of modular processes, and forming groups, based on hardware in the computer system, of one or more of the plurality of modular processes. A fault within a group is detected, and recovery from the detected fault is accomplished without affecting processes or hardware in other groups.

Abstract: The present invention provides a computer system having a modular control process, and a modular device driver process that works in conjunction with the control process. The device driver process is capable of continuing operation even if the control process is terminated, for example, upon detection of a fault. In one aspect, the invention provides a network device that includes a control plane and a data plane. The control plane includes a modular control application for establishing and terminating network connections, and the data plane has an independent, modular device driver process for transmitting data over network connections established by the control application. The device driver process is capable of continuing to transmit data over established network connections even if the control application is terminated.

Abstract: The present invention provides a method and apparatus for supporting multiple redundancy schemes in a single network device. In one network device, various redundancy schemes are supported including 1:1, 1+1, 1:N, no redundancy or a combination of redundancy schemes. In addition, the redundancy scheme or schemes for physical network device cards (i.e., universal port cards) or ports may be different from the redundancy scheme or schemes for forwarding network device cards. For example, a network manager may want to provide 1:1 or 1+1 redundancy for all universal port cards and/or ports but only 1:N redundancy for each N group of forwarding cards.