Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: The present invention relates to compounds which are useful as inhibitors of PTPN11 for the treatment or prevention of cancer and other PTP-mediated diseases. Disclosed herein are new compounds and compounds based on pyrazolopyrazines and their application as pharmaceuticals for the treatment of disease.

Abstract: A system for integrating third-party software components with point of sale (POS) systems includes a memory and a processor in communication therewith. The processor deploys a POS adapter on a POS system. The POS adapter configures a framework for the POS system, interacts with transaction data generated by the POS system, generates an API request based on the first configured framework, accesses a façade gateway based on the API request, and receives one or more responses to the first API request from the façade gateway. The façade gateway translates the API request to be interpretable by the third-party software components, transmits the translated API request to the third-party software components, receives a response to the API request from the third-party software components, translates the response to be interpretable by the POS adapter, and transmits the translated response to the POS adapter such that it is executable by the POS system.

Abstract: A device for storing electrical energy comprises a photo electrode, having a semiconductor layer with a photo dye thereon, a counter electrode, a reservoir comprising a solvent, a first redox mediator for enabling a redox reaction at the photo electrode, a second redox mediator for enabling a redox reaction at the counter electrode, wherein the photo electrode and the counter electrode are at least partly in the solvent, the first redox mediator is adapted to form an entity that is soluble in the solvent when the first redox mediator is in its reduced state, and an entity that is insoluble in the solvent when the first redox mediator is in its oxidized state.

Abstract: A method for forming a control arm is provided. The method includes providing an insert and a mold and also includes overcasting the insert within a metal in the mold. The insert defines a recess that is shaped for receiving a mating component. After the insert is overcast within the metal, the mating component may be positioned or mounted within the recess of the insert. A related control arm is also provided.

Abstract: A method for forming a control arm is provided. The method includes providing an insert and a mold and also includes overcasting the insert within a metal in the mold. The insert defines a recess that is shaped for receiving a mating component. After the insert is overcast within the metal, the mating component may be positioned or mounted within the recess of the insert. A related control arm is also provided.

Abstract: A curling iron operable to protect a portion of the user's skin that is adjacent the heating element from incidental contact with the heating element. The curling iron further includes a handle that is integrally mounted to the heating element. A shield is slidably mounted to the handle and is configured to be deployed to substantially extend the length of the heating element. The shield is further configured to be rotatable about the circumference of the heating element so as to maintain a position such that the shield is intermediate the heating element and the user's skin.

Abstract: A light weight storage bag specifically designed for various types of boots and accessories. The bag fully opens to securely hold one or two pairs of boots while protecting them from moisture and dust in a neat, organized and fashionable manner.

Abstract: A gathering gauge for assisting in the fabrication of a gather in a sewn article of manufacture. The gathering gauge is used to evenly distribute a given length of a fabric over a selected gather length, thereby eliminating guess work normally associated with such task. The gathering gauge is an elongated member defining a first slit for receiving and holding one end of a thread used to gather the fabric. A plurality of second slits is provided for receiving and holding a further portion of the thread. The second slits are disposed along the length of the gathering gauge at pre-selected distances from the first slit. A measuring guide is provided for determining the distance between the first slit and each individual second slit. Thus, depending upon the length of the fabric to be gathered, and either the length of the gather or the amount of gather desired, a particular second slit is selected.

Abstract: A puff quilt square maker and method for fabricating a puff quilt square for use in fabricating a quilt or other similar article, such as a child's book, clothing, or decorative article. The puff quilt square maker is used to fabricate puffs in quitting of various shapes and sizes, including the size of the design and the height of the puff, in order to fabricate virtually any design in soft sculpture. A gathering guide is used to gauge each gathered edge of a piece of fabric. The gathering guide is provided with a first slit for receiving and holding one end of the thread used to gather the fabric and a plurality of second slits for receiving and holding a further portion of the thread. The puff quilt square maker includes a core and a guide ring for fabricating a puff. The fabric is placed over the core, with a reference mark positioned over the center of the core. After the fabric has been aligned with the core, the guide ring is slipped over the fabric to the bottom extent of the core.

Abstract: Provided is a black ink jet ink which exhibits excellent non-fading properties. The ink jet ink is comprised of water, carbon black, cyan and magenta pigments, a water immiscible organic compound exhibiting a high boiling point, and a water miscible compound. The combination of the water immiscible compound and the water miscible compound provides for excellent anti-crusting properties.

Abstract: Provided is an ink jet ink comprised of water, pigment, a water immiscible organic compound exhibiting a high boiling point, and a water miscible compound. The combination of the water immiscible compound and the water miscible compound provides for excellent anti-crusting properties, and provides an ink which upon printing makes a round dot, and which printed images exhibit excellent waterfastness, lightfastness and wet rub resistance.

Abstract: An improvement in a food processor of the type which includes a working bowl mountable on a base housing and enclosing rotatable food processing tools. The bowl includes a removable cover having a food receiving hopper therethrough. The improvement comprises a food pusher which is selectively insertable into the hopper and is in the form of an ingredient dispensing receptable with a dispensing opening for metering an ingredient from the receptacle into the bowl.