Abstract: Methods and devices for delivering therapeutic or diagnostic energy (e.g., light, ultrasound, ionizing radiation (e.g., x-ray), vibration, heat energy, etc.) into the eye. An energy emitting device is positioned on the eye and used to deliver energy into the eye. The device may be constructed to allow the subject's eyelids to open and close while the device is positioned on the eye. The device is useable for various energy based or energy-mediated therapies, including crosslinking of corneal collagen, light therapy, photodynamic therapy, photo-activation of drugs, etc.

Abstract: Consistent with the present disclosure a method is provided in which a plurality of surgical meshes are provided, each of which may include a coating that has a chromophore. Alternatively, each mesh has a plurality of rivets or tacks that include the chromophore. The meshes may then be positioned to overlap one another or be provided adjacent one another inside the body cavity such that the mesh cover the wound site. The meshes may then be exposed to light at a wavelength that activates the chromophore and causes the meshes to adhere to one another and the underlying tissue. In one example, the coating or the tacks includes a combination of relatively high concentration derivatized collagen and riboflavin, lumiflavin or lumichrome.

Abstract: Methods and devices for delivering therapeutic or diagnostic energy (e.g., light, ultrasound, ionizing radiation (e.g., x-ray), vibration, heat energy, etc.) into the eye. An energy emitting device is positioned on the eye and used to deliver energy into the eye. The device may be constructed to allow the subject's eyelids to open and close while the device is positioned on the eye. The device is useable for various energy based or energy-mediated therapies, including crosslinking of corneal collagen, light therapy, photodynamic therapy, photo-activation of drugs, etc.

Abstract: Consistent with the present invention, a tube is provided that contains both a sensing and a laser delivery fiber to the target area. The length of the tube can be varied to any desired length. The end portion of the tube includes a second piece, which is a cap having two through holes or passages. These holes can be formed by standard machining or micromaching methods. The first hole can accommodate the sensing fiber, while the second hole contains the laser delivery fiber. The first and second holes extend in first and second directions, respectively, and form an angle therebetween such that the sensor fiber viewing area is within the radiation area created by the laser delivery fiber. Accordingly, the sensor fiber receives energy emitted from a central portion of the radiation area so that the temperature of the exposed tissue can be accurately determined.

Abstract: The invention provides a wearable device for delivery of light of a desired wavelength and power to the cornea of a subject. The device includes a frame for attachment of a light source housing which includes a light source and a lens positioned in the housing to allow light to be directed to the eye of the subject, and the light source is operably linked to a power source. The invention provides method for the prevention and treatment of ocular disease including infection, neoplasia, and corneal dystrophies. The device of the invention can be used in conjunction with photoactive therapeutic agents.

Abstract: Consistent with the present invention, a tube is provided that contains both a sensing and a laser delivery fiber to the target area. The length of the tube can be varied to any desired length. The end portion of the tube includes a second piece, which is a cap having two through holes or passages. These holes can be formed by standard machining or micromaching methods. The first hole can accommodate the sensing fiber, while the second hole contains the laser delivery fiber. The first and second holes extend in first and second directions, respectively, and form an angle therebetween such that the sensor fiber viewing area is within the radiation area created by the laser delivery fiber. Accordingly, the sensor fiber receives energy emitted from a central portion of the radiation area so that the temperature of the exposed tissue can be accurately determined.