Patents by Inventor Barbara Burton

Barbara Burton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lysosomal acid lipase deficiency compositions and methods
    Patent number: 11235036
    Abstract: Compositions and methods relating to potentially pathogenic mutations in the nucleotide sequence of a human LIPA gene. Some LIPA gene products have been discovered to be associated with reduced lysosomal acid lipase (LAL) activity.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: February 1, 2022
    Assignee: Alexion Pharmaceuticals, Inc.
    Inventors: Andrew Hutchinson, John V. W. Reynders, Guillermo del Angel, Nina Jain, Christen D. Forbes, Xiao-Qin Ren, Barbara Burton
  • METHODS FOR REDUCING LIVER FIBROSIS AND TREATING LYSOSOMAL ACID LIPASE DEFICIENCY IN PATIENTS BASED ON ISHAK FIBROSIS STAGE
    Publication number: 20200038491
    Abstract: The present invention provides methods of reducing liver fibrosis in a human patient with a lysosomal acid lipase (LAL) deficiency comprising administering sebelipase alfa to the patient, wherein the patient has been determined to have at least a one point reduction (e.g., a ?1 point reduction or a ?2 point reduction) in Ishak fibrosis stage after administration compared to a baseline Ishak fibrosis stage obtained from the patient prior to administration. Also provided are methods of treating a human patient with a lysosomal acid lipase (LAL) deficiency comprising administering sebelipase alfa to the patient, wherein the patient has been determined to have at least a one point reduction (e.g., a ?1 point reduction or a ?2 point reduction) in Ishak fibrosis stage after administration compared to a baseline Ishak fibrosis stage obtained from the patient prior to administration.
    Type: Application
    Filed: September 28, 2017
    Publication date: February 6, 2020
    Inventors: Anthony QUINN, Zachary GOODMAN, Barbara BURTON, Andrew RANKIN, Mark FRIEDMAN, Paresh SONI
  • LYSOSOMAL ACID LIPASE DEFICIENCY COMPOSITIONS AND METHODS
    Publication number: 20190151420
    Abstract: Compositions and methods relating to potentially pathogenic mutations in the nucleotide sequence of a human LIPA gene. Some LIPA gene products have been discovered to be associated with reduced lysosomal acid lipase (LAL) activity.
    Type: Application
    Filed: June 16, 2017
    Publication date: May 23, 2019
    Applicant: ALEXION PHARMACEUTICALS, INC.
    Inventors: Andrew Hutchinson, John V.W. Reynders, Guillermo del Angel, Nina Jain, Christen D. Forbes, Xiao-Qin Ren, Barbara Burton