Patents by Inventor Barbara Capecchi

Barbara Capecchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for generating immune responses utilizing nucleic acids encoding fusion proteins comprising CD4 minimal modules and invasin polypeptides that are capable of binding to the HIV envelope and exposing cryptic neutralization epitopes
    Patent number: 8568734
    Abstract: Fusion proteins comprising CD4 minimal modules that bind to HIV Env polypeptides in a non-CD4 backbone are described. Also described are complexes of these fusion proteins with Env as well as methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides are also provided.
    Type: Grant
    Filed: March 21, 2012
    Date of Patent: October 29, 2013
    Assignee: Novartis Vaccines and Diagnostics Inc.
    Inventors: Vega Masignani, Maria Scarselli, Barbara Capecchi, Victoria Sharma, Susan W Barnett, Indresh K. Srivastava, Rino Rappuoli
  • FUSION PROTEINS COMPRISING CD4 MINIMAL MODULES AND METHODS OF USE THEREOF
    Publication number: 20120177657
    Abstract: Fusion proteins comprising CD4 minimal modules that bind to HIV Env polypeptides in a non-CD4 backbone are described. Also described are complexes of these fusion proteins with Env as well as methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides are also provided.
    Type: Application
    Filed: March 21, 2012
    Publication date: July 12, 2012
    Applicant: NOVARTIS VACCINES AND DIAGNOSTICS, INC.
    Inventors: Vega MASIGNANI, Maria SCARSELLI, Barbara CAPECCHI, Victoria SHARMA, Susan W. BARNETT, Indresh K. SRIVASTAVA, Rino RAPPUOLI
  • Fusion proteins comprising CD4 minimal modules and invasin polypeptides that are capable of binding to the HIV envelope and exposing cryptic neutraliziation epitopes
    Patent number: 8206720
    Abstract: Fusion proteins comprising CD4 minimal modules that bind to HIV Env polypeptides in a non-CD4 backbone are described. Also described are complexes of these fusion proteins with Env as well as methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides are also provided.
    Type: Grant
    Filed: June 8, 2005
    Date of Patent: June 26, 2012
    Assignee: Novartis Vaccines & Diagnostics, Inc
    Inventors: Vega Masignani, Maria Scarselli, Barbara Capecchi, Victoria Sharma, Susan W. Barnett, Indresh K. Srivastava, Rino Rappuoli
  • Polypeptides for oligomeric assembly of antigens
    Patent number: 7915218
    Abstract: A system for expressing antigenic polypeptides in oligomeric form fuses the antigenic polypeptide to an oligomerisation polypeptide such that the oligomerisation polypeptide can interact with other oligomerisation polypeptides and bring multiple copies of the antigenic polypeptide into close proximity in the form of an oligomer. Expressing the polypeptides in oligomeric form in this way can improve their immunogenicity compared to a monomeric form.
    Type: Grant
    Filed: July 22, 2005
    Date of Patent: March 29, 2011
    Assignee: Novartis AG
    Inventors: Barbara Capecchi, Vega Masignani, Rino Rappuoli, Maria Scarselli
  • Fusion Proteins Comprising CD4 Minimal Modules and Methods of Use Thereof
    Publication number: 20100183653
    Abstract: Fusion proteins comprising CD4 minimal modules that bind to HIV Env polypeptides in a non-CD4 backbone are described. Also described are complexes of these fusion proteins with Env as well as methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides are also provided.
    Type: Application
    Filed: June 8, 2005
    Publication date: July 22, 2010
    Applicant: CHIRON CORPORATION
    Inventors: Vega Masignani, Maria Scarselli, Barbara Capecchi, Victoria Sharma, Susan W. Barnett, Indresh K. Srivastava, Rino Rappuoli
  • Inhibitors Based on Fusion, Hr1 and Hr2 Sequences in Bacterial Adhesin
    Publication number: 20090176699
    Abstract: A known surface adhesin (NadA) in Neisseria meningitidis contains sequences which correspond to the fusion peptide, HR1 repeat and HR2 repeat seen in the envelope protein of viruses. Fusion inhibitors may thus be used to inhibit meningococcal infection, and the invention provides a compound that can bind to the heptad repeat sequence(s) HR1 and/or HR2 of the NadA adhesin on the surface of a meningococcus, thereby inhibiting the ability of the meningococcus either to infect a host organism or to spread an existing infection.
    Type: Application
    Filed: July 6, 2005
    Publication date: July 9, 2009
    Applicant: CHIRON SRL
    Inventors: Vega Masignani, Rino Rappuoli, Barbara Capecchi, Silvana Savino, Maria Beatrice Arico
  • Polypeptides for Oligomeric Assembly of Antigens
    Publication number: 20080260769
    Abstract: A system for expressing antigenic polypeptides in oligomeric form fuses the antigenic polypeptide to an oligomerisation polypeptide such that the oligomerisation polypeptide can interact with other oligomerisation polypeptides and bring multiple copies of the antigenic polypeptide into close proximity in the form of an oligomer. Expressing the polypeptides in oligomeric form in this way can improve their immunogenicity compared to a monomeric form.
    Type: Application
    Filed: July 22, 2005
    Publication date: October 23, 2008
    Inventors: Barbara Capecchi, Vega Masignani, Rino Rappuoli, Maria Scarselli