Patents by Inventor Barbara Chapman

Barbara Chapman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MERCHANDISING
    Publication number: 20090210359
    Abstract: The invention relates an apparatus (20) for merchandising including a point of sale (29), a stock of at least one product for sale (36, 38, 40), and a display point (22, 24, 26) having at least one package (30, 32, 34), the package including a replica of the at least one product for sale, wherein the apparatus is arranged to enable the package to be exchanged for the at least one product.
    Type: Application
    Filed: March 22, 2007
    Publication date: August 20, 2009
    Applicant: Chapman Research Limited
    Inventor: Barbara Chapman
  • Protein complexes having factor VIII:C activity and production thereof
    Publication number: 20060122376
    Abstract: Recombinant protein complexes having human Factor VIII:C activity are expressed in a eukaryotic host cell by transforming the host cell with first and second expression cassettes encoding a first polypeptide substantially homologous to human Factor VIII:C A domain and a second polypeptide substantially homologous to human Factor VIII:C C domain, respectively. In the present invention, the first polypeptide may be extended having at its C-terminal a human Factor VIII:C B domain N-terminal peptide, a polypeptide spacer of 3-40 amino acids, and a human Factor VIII:C B domain C-terminal peptide. Expression of the second polypeptide is improved by employing an .alpha.sub.1-antitrypsin signal sequence.
    Type: Application
    Filed: November 30, 2005
    Publication date: June 8, 2006
    Applicant: Chiron Corporation
    Inventors: Barbara Chapman, Rae Burke, Mirella Rasmussen, Jan Mikkelson
  • Protein complexes having factor VIII:C activity and production thereof
    Publication number: 20040137579
    Abstract: Recombinant protein complexes having human Factor VIII:C activity are expressed in a eukaryotic host cell by transforming the host cell with first and second expression cassettes encoding a first polypeptide substantially homologous to human Factor VIII:C A domain and a second polypeptide substantially homologous to human Factor VIII:C C domain, respectively. In the present invention, the first polypeptide may be extended having at its C-terminal a human Factor VIII:C B domain N-terminal peptide, a polypeptide spacer of 3-40 amino acids, and a human Factor VIII:C B domain C-terminal peptide. Expression of the second polypeptide is improved by employing an &agr;1-antitrypsin signal sequence.
    Type: Application
    Filed: December 1, 2003
    Publication date: July 15, 2004
    Applicants: Chiron Corporation, Novo Nordisk A/S
    Inventors: Barbara Chapman, Rae Lyn Burke, Mirella Ezban Rasmussen, Jan Mollar Mikkelson
  • Protein complexes having factor VIII:C activity and production thereof
    Publication number: 20030170825
    Abstract: Recombinant protein complexes having human Factor VIII:C activity are expressed in a eukaryotic host cell by transforming the host cell with first and second expression cassettes encoding a first polypeptide substantially homologous to human Factor VIII:C A domain and a second polypeptide substantially homologous to human Factor VIII:C C domain, respectively. In the present invention, the first polypeptide may be extended having at its C-terminal a human Factor VIII:C B domain N-terminal peptide, a polypeptide spacer of 3-40 amino acids, and a human Factor VIII:C B domain C-terminal peptide. Expression of the second polypeptide is improved by employing an &agr;1-antitrypsin signal sequence.
    Type: Application
    Filed: September 26, 2002
    Publication date: September 11, 2003
    Applicant: Chiron Corporation
    Inventors: Barbara Chapman, Rae Lyn Burke, Mirella Ezban Rasmussen, Jan Moller Mikkelson
  • Protein complexes having factor VIII:C activity and production thereof
    Publication number: 20010016340
    Abstract: Recombinant protein complexes having human Factor VIII:C activity are expressed in a eukaryotic host cell by transforming the host cell with first and second expression cassettes encoding a first polypeptide substantially homologous to human Factor VIII:C A domain and a second polypeptide substantially homologous to human Factor VIII:C C domain, respectively. In the present invention, the first polypeptide may be extended having at its C-terminal a human Factor VIII:C B domain N-terminal peptide, a polypeptide spacer of 3-40 amino acids, and a human Factor VIII:C B domain C-terminal peptide. Expression of the second polypeptide is improved by employing an &agr;1-antitrypsin signal sequence.
    Type: Application
    Filed: December 22, 2000
    Publication date: August 23, 2001
    Applicant: Chiron Corporation and Novo Nordisk A/S
    Inventors: Barbara Chapman, Rae Lyn Burke, Mirella Ezban Rasmussen, Jan Moller Mikkelson
  • Protein complexes having factor VIII:C activity and production thereof
    Patent number: 6228620
    Abstract: Recombinant protein complexes having human Factor VIII:C activity are expressed in a eukaryotic host cell by transforming the host cell with first and second expression cassettes encoding a first polypeptide substantially homologous to human Factor VIII:C A domain and a second polypeptide substantially homologous to human Factor VIII:C C domain, respectively. In the present invention, the first polypeptide may be extended having at its C-terminal a human Factor VIII:C B domain N-terminal peptide, a polypeptide spacer of 3-40 amino acids, and a human Factor VIII:C B domain C-terminal peptide. Expression of the second polypeptide is improved by employing an &agr;1-antitrypsin signal sequence.
    Type: Grant
    Filed: May 16, 1995
    Date of Patent: May 8, 2001
    Assignees: Chiron Corporation, Novo Nordisk A/S
    Inventors: Barbara Chapman, Rae Lyn Burke, Mirella Ezban Rasmussen, Jan Moller Mikkelson
  • Protein complexes having Factor VIII:C activity and production thereof
    Patent number: 6060447
    Abstract: Recombinant protein complexes having human Factor VIII:C activity are expressed in a eukaryotic host cell by transforming the host cell with first and second expression cassettes encoding a first polypeptide substantially homologous to human Factor VIII:C A domain and a second polypeptide substantially homologous to human Factor VIII:C C domain, respectively. In the present invention, the first polypeptide may be extended having at its C-terminal a human Factor VIII:C B domain N-terminal peptide, a polypeptide spacer of 3-40 amino acids, and a human Factor VIII:C B domain C-terminal peptide. Expression of the second polypeptide is improved by employing an .alpha..sub.1 -antitrypsin signal sequence.
    Type: Grant
    Filed: May 16, 1995
    Date of Patent: May 9, 2000
    Assignees: Chiron Corporation, Novo Nordisk A/S
    Inventors: Barbara Chapman, Rae Lyn Burke, Mirella Ezban Rasmussen, Jan Moller Mikkelson
  • Protein complexes having factor VIII:C activity and production thereof
    Patent number: 5789203
    Abstract: Recombinant protein complexes having human Factor VIII:C activity are expressed in a eukaryotic host cell by transforming the host cell with first and second expression cassettes encoding a first polypeptide substantially homologous to human Factor VIII:C A domain and a second polypeptide substantially homologous to human Factor VIII:C C domain, respectively. In the present invention, the first polypeptide may be extended having at its C-terminal a human Factor VIII:C B domain N-terminal peptide, a polypeptide spacer of 3-40 amino acids, and a human Factor VIII:C B domain C-terminal peptide. Expression of the second polypeptide is improved by employing an .alpha..sub.1 -antitrypsin signal sequence.
    Type: Grant
    Filed: June 27, 1994
    Date of Patent: August 4, 1998
    Assignees: Chiron Corporation, Novo Nordisk A/S
    Inventors: Barbara Chapman, Rae Lyn Burke, Mirella Ezban Rasmussen, Jan Moller Mikkelson
  • Protein complexes having Factor VIII:C activity and production thereof
    Patent number: 5595886
    Abstract: DNA constructs encoding human Factor VIII:C protein are disclosed. In particular, the DNA construct contains a nucleotide sequence that encodes a first polypeptide homologous to the A domain of human Factor VIII:C linked to a second polypeptide homologous to the C domain of human Factor VIII:C by a polypeptide spacer that comprises a peptide homologous to a human Ig heavy chain hinge region. Recombinant methods for producing human Factor VIII:C protein are also disclosed.
    Type: Grant
    Filed: December 3, 1993
    Date of Patent: January 21, 1997
    Assignee: Chiron Corporation
    Inventors: Barbara Chapman, Rae L. Burke