Patents by Inventor Barbara Chen

Barbara Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CELL NICHE ENGINEERING PLATFORM, MULTIPLEXED BIOCHIPS RESULTING THEREFROM AND METHODS OF USE THEREOF
    Publication number: 20240132819
    Abstract: Provided are cell niche engineering platform which represents a valuable in vitro tool for investigating physiological and pathological cellular activities, an all-in-one technology to engineer cell niche (particularly soluble cell niche factors) with retained bioactivities, a mask-free, non-contact, biocompatible and multiphoton-based microfabrication and micropatterning method for engineering a spatially and quantitatively controllable soluble proteins/bioactive factors and cell-cell adhesion molecules. An universal cell niche engineering platform is provided that contributes to reconstituting heterogeneous native soluble cell niche for signal transduction modeling and drug screening studies.
    Type: Application
    Filed: February 7, 2022
    Publication date: April 25, 2024
    Inventors: Pui Barbara CHAN, Chi Hung YIP, Abigail Dee CHEN, Xinna WANG, Nan HUANG
  • Useful indole compounds
    Patent number: 7960544
    Abstract: Indoles that have activity as inhibitors of FAAH are described as are indoles and indole derivatives that have activity as inhibitors of DAO.
    Type: Grant
    Filed: December 18, 2006
    Date of Patent: June 14, 2011
    Assignee: Ironwood Pharmaceuticals, Inc.
    Inventors: Wilmin Bartolini, Brian M. Cali, Barbara Chen, Yueh-Tyng Chien, Mark G. Currie, G. Todd Milne, James Philip Pearson, John Jeffrey Talley, Jane Yang, Craig Zimmerman, Charles Kim, Kevin Sprott, Timothy Barden, Regina Lundigran, Ara Mermerian
  • USEFUL INDOLE COMPOUNDS
    Publication number: 20090264653
    Abstract: Indoles that have activity as inhibitors of FAAH are described as are indoles and indole derivatives that have activity as inhibitors of DAO.
    Type: Application
    Filed: December 18, 2006
    Publication date: October 22, 2009
    Inventors: Wilmin Bartolini, Brian M Cali, Barbara Chen, Yueh-Tyng Chien, Mark G. Currie, G. Todd Milne, James Philip Pearson, John Jeffrey Talley, Jane Yang, Craig Zimmerman, Charles Kim, Kevin Sprott, Timothy Barden, Regina Lundigran, Ara Mermerian
  • Useful indole compounds
    Publication number: 20070203209
    Abstract: Indoles having various activities, including indoles that are CRTH2 are described. The compounds are useful for treating asthma, neuropathic pain, allegic rhinitis and other disorders.
    Type: Application
    Filed: August 18, 2006
    Publication date: August 30, 2007
    Inventors: Wilmin Bartolini, Brian Cali, Barbara Chen, Yueh-Tyng Chien, Mark Currie, G. Milne, James Pearson, John Talley, Jing Yang, Craig Zimmerman, Alex Monreal
  • Stable and palatable oral liquid sumatriptan compositions
    Publication number: 20070166336
    Abstract: The present invention is directed to improved oral liquid compositions that include sumatriptan, or a pharmaceutically acceptable salt or metabolite thereof, and a pharmaceutically acceptable carrier that includes a liquid portion of the composition. The compositions are substantially free of oxidation impurities. Typically, the compositions include a sweetening agent and a flavoring agent, or a bitterness-reducing agent and flavoring agent. Processes of preparing such compositions and methods of administering such compositions are also included.
    Type: Application
    Filed: December 13, 2006
    Publication date: July 19, 2007
    Inventors: David Delmarre, Ajit Narang, Kaidi Zhao, Meagan Weldele, Barbara Chen, Carlos-Julian Centeno, Danchen Gao
  • Modulators of CRTH2 Activity
    Publication number: 20070161698
    Abstract: Modulators of the CRTH2 receptor and their use in the treatment of various disorders, including asthma are described.
    Type: Application
    Filed: March 13, 2007
    Publication date: July 12, 2007
    Inventors: Yueh-Tyng Chien, G. Milne, Mark Currie, John Talley, Brian Cali, Barbara Chen, Craig Zimmerman, Jing Yang
  • Modulators of CRTH2 activity
    Patent number: 7205329
    Abstract: Modulators of the CRTH2 receptor and their use in the treatment of various disorders, including asthma are described.
    Type: Grant
    Filed: July 18, 2005
    Date of Patent: April 17, 2007
    Assignee: Microbia, Inc.
    Inventors: Yueh-Tyng Chien, G. Todd Milne, Mark G. Currie, John Jeffrey Talley, Brian M. Cali, Barbara Chen, Craig Zimmerman, Jing Jing Yang
  • Modulators of CRTH2 activity
    Publication number: 20060135591
    Abstract: Modulators of the CRTH2 receptor and their use in the treatment of various disorders, including asthma are described.
    Type: Application
    Filed: July 18, 2005
    Publication date: June 22, 2006
    Inventors: Yueh-Tyng Chien, G. Milne, Mark Currie, John Talley, Brian Cali, Barbara Chen, Craig Zimmerman, Jing Yang
  • Synthesis of COX-2 and FAAH inhibitors
    Publication number: 20050234244
    Abstract: Methods for preparing indoles that are useful COX-2 inhibitors and intermediates useful in such methods are described.
    Type: Application
    Filed: November 1, 2004
    Publication date: October 20, 2005
    Inventors: Wilmin Bartolini, Brian Cali, Barbara Chen, Yueh-Tyng Chien, Mark Currie, G. Milne, James Pearson, John Talley, Craig Zimmerman
  • Modulators of CRTH2, COX-2 and FAAH
    Publication number: 20050234030
    Abstract: Certain substituted indoles that are modulators of one or more or of CRTH2, COX-2 AND FAAH are described. The compounds are useful for treatment of pain and/or inflammation as well as other disorders.
    Type: Application
    Filed: January 3, 2005
    Publication date: October 20, 2005
    Inventors: Wilmin Bartolini, Brian Cali, Barbara Chen, Yueh-Tyng Chien, Mark Currie, G. Milne, James Pearson, John Talley, Jing Yang, Craig Zimmerman
  • Cycloalkyl alkanoic acids as integrin receptor antagonists
    Patent number: 6949578
    Abstract: The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the ?v?3 and/or ?v?5 integrin.
    Type: Grant
    Filed: July 14, 2004
    Date of Patent: September 27, 2005
    Assignee: Pharmacia Corporation
    Inventors: Ish Kumar Khanna, Michael Clare, Alan F. Gasiecki, Thomas Rogers, Barbara Chen, Mark Russell, Hwang-Fun Lu
  • Heteroarylalkanoic acids as integrin receptor antagonists
    Patent number: 6933304
    Abstract: The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively antagonizing the ?V?3 and/or the ?V?5 integrin without significantly antagonizing the IIb/IIIa or ?V?6 integrin.
    Type: Grant
    Filed: June 15, 2001
    Date of Patent: August 23, 2005
    Assignee: Pharmacia Corporation
    Inventors: Srinivasan Raj Nagarajan, Ish Kumar Khanna, Michael B. Tollefson, Scott B. Mohler, Barbara Chen, Mark Russell, Balekudru Devadas, Thomas D. Penning, Lori A. Schretzman, Dale P. Spangler, Mark Laurence Boys, Nizal Samuel Chandrakumar, Hung-Fun Lu
  • Cycloalkyl alkanoic acids as integrin receptor antagonists derivatives
    Patent number: 6921767
    Abstract: The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the ?v?3 and/or ?v?5 integrin.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: July 26, 2005
    Assignee: Pharmacia Corporation
    Inventors: Nagarajan R. Srinivasan, Ish Kumar Khanna, Michael Clare, Alan Gasiecki, Thomas Rogers, Barbara Chen, Mark Russell, Hwang-Fun Lu, Yu Yi, Renee M. Huff, Bipinchandra N. Desai, Balekudru Devadas, Mihir D. Parikh, Thomas Penning
  • Cycloalkyl alkanoic acids as integrin receptor antagonists
    Patent number: 6900232
    Abstract: The present invention relates to a class of compounds represented by the Formula I Wherein A1 is a pyridinyl of the formula optionally substituted by one or more Rk selected from the group consisting of hydroxy, alkyl, alkoxy, alkoxyalkyl, thioalkyl, haloalkyl, cyano, amino alkylamino, halogen, acylamino, sulfonamide and —COR; and R is hydroxy, alkoxy, alkyl or amino; and pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the ?v?3 and/or ?v?5 integrin.
    Type: Grant
    Filed: June 15, 2001
    Date of Patent: May 31, 2005
    Assignee: Pharmacia Corporation
    Inventors: Ish Kumar Khanna, Michael Clare, Alan F. Gasiecki, Thomas Rogers, Barbara Chen, Mark Russell, Hwang-Fun Lu
  • Heteroarylalkanoic acids as integrin receptor antagonists derivatives
    Publication number: 20050043344
    Abstract: The present invention relates to pharmaceutical compositions comprising compounds of the Formula I, or a pharmaceutically acceptable salt thereof, and methods of selectively inhibiting or antagonizing the ?V?3 and/or the ?V?5 integrin without significantly inhibiting the ?V?6 integrin.
    Type: Application
    Filed: December 22, 2003
    Publication date: February 24, 2005
    Inventors: Mark Boys, Lori Schretzman, Michael Tollefson, Nizal Chandrakumar, Ish Khanna, Maria Nguyen, Victoria Downs, Scott Mohler, Glen Gesicki, Thomas Penning, Barbara Chen, Yaping Wang, Albert Khilevich, Bipinchandra Desai, Yi Yu, John Wendt, Heather Stenmark, Hongwei Wu, Renee Huff, Srinivasan Nagarajan, Balekudru Devadas, Hwang-Fun Lu, Mark Russell, Dale Spangler, Mihir Parikh
  • COX-2 and FAAH inhibitors
    Publication number: 20050032747
    Abstract: The invention features compounds that inhibit COX-2 and/or FAAH. The COX-2 inhibitors are selective COX-2 inhibitors in that they are selective for COX-2 compared to COX-1. Certain of the FAAH inhibitors are selective for FAAH relative to COX-2. Certain of the COX-2 inhibitors, in addition for being selective for COX-2 relative to COX-1, are selective for COX-2 relative to FAAH.
    Type: Application
    Filed: July 1, 2004
    Publication date: February 10, 2005
    Inventors: Wilmin Bartolini, Brian Cali, Barbara Chen, Yueh-Tyng Chien, Mark Currie, G. Milne, James Pearson, John Talley, Craig Zimmerman
  • Thiazole compounds as integrin receptor antagonists derivatives
    Publication number: 20050004189
    Abstract: The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the ?v?3 and/or the ?v?5 integrin without significantly inhibiting the ?v?6 integrin.
    Type: Application
    Filed: December 19, 2003
    Publication date: January 6, 2005
    Inventors: John Wendt, Heather Stenmark, Hongwei Wu, Yaping Wang, Barbara Chen, Thomas Penning, Victoria Downs, Mark Boys, Mark Russell, Dale Spangler
  • Pyrazole compounds as integrin receptor antagonists derivatives
    Publication number: 20050004200
    Abstract: The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the ?V?3 and/or the ?V?5 integrin without significantly inhibiting the ?V?6 integrin.
    Type: Application
    Filed: December 19, 2003
    Publication date: January 6, 2005
    Inventors: Thomas Penning, Albert Khilevich, Barbara Chen, Preete Gandhi, Yaping Wang, Victoria Downs, Mark Boys, Mark Russell, Dale Spangler, Renee Huff
  • Cycloalkyl alkanoic acids as integrin receptor antagonists
    Publication number: 20040259869
    Abstract: The present invention relates to a class of compounds represented by the Formula I 1
    Type: Application
    Filed: July 14, 2004
    Publication date: December 23, 2004
    Inventors: Ish Kumar Khanna, Michael Clare, Alan F. Gasiecki, Thomas Rogers, Barbara Chen, Hwang-Fun Lu
  • Cycloalkyl alkanoic acids as integrin receptor antagonists derivatives
    Publication number: 20040092538
    Abstract: The present invention relates to a class of compounds represented by the Formula I 1
    Type: Application
    Filed: December 20, 2002
    Publication date: May 13, 2004
    Inventors: Srinivasan R. Nagarajan, Ish Kumar Khanna, Michael Clare, Alan Gasiecki, Thomas Rogers, Barbara Chen, Mark Russell, Hwang-Fun Lu, Yu Yi, Renee M. Huff, Bipinchandra N. Desai, Balekudru Devadas, Mihir D. Parikh, Thomas Penning