Patents by Inventor Barbara Chu

Barbara Chu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Replicative RNA reporter systems
    Patent number: 5364760
    Abstract: Highly sensitive methods for assaying for biopolymers, such as by immunoassay or nucleic acid probe hybridization assay, and compositions for carrying out the methods, are provided. The methods employ as reporter group a RNA capable of being autocatalytically replicated by an RNA-dependent RNA polymerase, such as the replicase of bacteriophage Q.beta.. The high sensitivity of the assay methods is due to the rapid, exponential increase in concentration of such a replicative RNA, associated specifically with biopolymer analyte, that can be achieved by autocatalytic RNA replication.
    Type: Grant
    Filed: September 22, 1992
    Date of Patent: November 15, 1994
    Assignees: The Salk Institute for Biological Studies, The Trustees of Columbia University
    Inventors: Barbara Chu, Fred R. Kramer, Paul Lizardi, Leslie E. Orgel
  • Replicative RNA reporter systems
    Patent number: 4957858
    Type: Grant
    Filed: April 16, 1988
    Date of Patent: September 18, 1990
    Assignees: The Salk Instute for Biological Studies, The Trustees of Columbia University
    Inventors: Barbara Chu, Fred R. Kramer, Paul Lizardi, Leslie E. Orgel