Patents by Inventor Barbara E. Kurys

Barbara E. Kurys has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-(pyridinylamino) isoindolines and related compounds
    Patent number: 6004977
    Abstract: Novel N-(pyridinylamino)isoindolines and related compounds, intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing the N-(pyridinylamino)isoindolines and related compounds, the intermediates or compositions thereof are disclosed.
    Type: Grant
    Filed: October 29, 1997
    Date of Patent: December 21, 1999
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Barbara E. Kurys, David M. Fink, Brian S. Freed, Gregory H. Merriman
  • Pyridiniminyl-1,2-benzisoxazoles and -benzisothiazoles
    Patent number: 5948798
    Abstract: Novel pyridiniminyl-1,2-benzisoxazoles and -benzisothiazoles, intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing the 1,2-benzisoxazoles and -benzisothiazoles and intermediates, or compositions thereof are disclosed.
    Type: Grant
    Filed: October 30, 1997
    Date of Patent: September 7, 1999
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: David M. Fink, Barbara E. Kurys, Gregory M. Shutske, John D. Tomer, IV
  • Pyridiniminyl-1,2-benzisothiazoles
    Patent number: 5728717
    Abstract: Novel pyridiniminyl-1,2-benzisoxazoles and -benzisothiazoles, intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing the 1,2-benzisoxazoles and -benzisothiazoles and intermediates, or compositions thereof are disclosed.
    Type: Grant
    Filed: February 26, 1997
    Date of Patent: March 17, 1998
    Assignee: Hoechst Marion Roussel Inc.
    Inventors: David M. Fink, Barbara E. Kurys, Gregory M. Shutske, John D. Tomer, IV
  • 4- and 6-carbamates related to physostigmine and intermediates for the preparation thereof
    Patent number: 5726323
    Abstract: This invention relates to 4- and 6-carbamates related to physostigmine of the formula ##STR1## where R.sub.1 is alkyl, cycloalkyl, bicycloalkyl, aryl or arylloweralkyl; R.sub.2 is hydrogen or alkyl or the group --NR.sub.1 R.sub.2 taken together forms a monocyclic or bicyclic ring of 5 to 12 carbons; m is 0, 1, or 2; each X is independently hydrogen, halogen, loweralkyl, nitro or amino; and the pharmaceutically acceptable acid addition salts thereof, and where applicable, the geometric and optical isomers and racemic mixtures thereof. This invention also relates to novel intermediates useful in the preparation of the 4- and 6-carbamates. The compounds of this invention display utility for alleviating various memory dysfunctions characterized by a decreased cholinergic function, such as Alzheimer's disease.
    Type: Grant
    Filed: September 5, 1996
    Date of Patent: March 10, 1998
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Edward J. Glamkowski, Barbara E. Kurys
  • Pyridiniminyl-1,2-benzisoxazoles and -benzisothiazoles
    Patent number: 5668154
    Abstract: Novel pyridiniminyl-1,2-benzisoxazoles and -benzisothiazoles, intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing the 1,2-benzisoxazoles and -benzisothiazoles and intermediates, or compositions thereof are disclosed.
    Type: Grant
    Filed: May 2, 1996
    Date of Patent: September 16, 1997
    Assignee: Hoechst Marion Roussel Inc.
    Inventors: David M. Fink, Barbara E. Kurys, Gregory M. Shutske, John D. Tomer, IV
  • 4-and 6-carbamates related to physostigmine and intermediates for the preparation thereof
    Patent number: 5591864
    Abstract: This invention relates to 4- and 6-carbamates related to physostigmine of the formula ##STR1## where R.sub.1 is alkyl, cycloalkyl, bicycloalkyl, aryl or arylloweralkyl; R.sub.2 is hydrogen or alkyl or the group --NR.sub.1 R.sub.2 taken together forms a monocyclic or bicyclic ring of 5 to 12 carbons; m is 0, 1, or 2; each X is independently hydrogen, halogen, loweralkyl, nitro or amino; and the pharmaceutically acceptable acid addition salts thereof, and where applicable, the geometric and optical isomers and racemic mixtures thereof. This invention also relates to novel intermediates useful in the preparation of the 4- and 6-carbamates. The compounds of this invention display utility for alleviating various memory dysfunctions characterized by a decreased cholinergic function, such as Alzheimer's disease.
    Type: Grant
    Filed: April 27, 1992
    Date of Patent: January 7, 1997
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Edward J. Glamkowski, Barbara E. Kurys
  • 8-azabicyclo[3.2.1]octane methanone and corresponding oximes
    Patent number: 5340936
    Abstract: This invention relates to compounds of the formula ##STR1## where X is --0--, --S--or --NH--;Y is hydrogen, halogen and loweralkoxy;p is 1 or 2;n is 2, 3 or 4;R is hydrogen, loweralkyl, loweralkoxy, hydroxy, halogen, amino, loweralkylamino, nitro, loweralkylthio, trifiuoromethoxy, cyano, trifluoromethyl, ##STR2## where aryl is ##STR3## R.sub.1 is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, carboxyl, loweralkylamino, nitro, loweralkylthio, cyano, and trifluoromethyl;m is 1 or 2; a pharmaceutically acceptable acid addition salt thereof and, where applicable the geometric and optical isomers and racemic mixtures thereof.The compounds and compositions of this invention are useful as antipsychotic agent, as 5-HT.sub.3 receptor antagonists and as inhibitors of the reuptake of serotonin.
    Type: Grant
    Filed: March 25, 1993
    Date of Patent: August 23, 1994
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Edward J. Glamkowski, David M. Fink, Barbara E. Kurys, Yulin Chiang
  • Heteroaryl-8-azabicyclo[3,2,1]octanes as antipsychotic agents, 5-HT.sub.3 receptor antagonists and inhibitors of the reuptake of serotonin
    Patent number: 5334599
    Abstract: This invention relates to compounds of the formula ##STR1## where X is --O--, --S-- or --NH--;Y is hydrogen, halogen and loweralkoxy;p is 1 or 2;n is 2, 3 or 4;R is hydrogen, loweralkyl, loweralkoxy, hydroxy, halogen, amino, loweralkylamino, nitro, loweralkylthio, trifiuoromethoxy, cyano, trifiuoromethyl, ##STR2## R.sub.1 is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, carboxyl, loweralkylamino, nitro, loweralkylthio, cyano, and trifiuoromethyl;m is 1 or 2; a pharmaceutically acceptable acid addition salt thereof and, where applicable the geometric and optical isomers and racemic mixtures thereof.The compounds and compositions of this invention are useful as antipsychotic as 5-HT.sub.3 receptor antagonists and as inhibitors of the reuptake of serotonin.
    Type: Grant
    Filed: March 25, 1993
    Date of Patent: August 2, 1994
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Edward J. Glamkowski, David M. Fink, Barbara E. Kurys, Yulin Chiang
  • 4- and 6-carbamates related to physostigmine and intermediates for the preparation thereof
    Patent number: 5260452
    Abstract: This invention relates to 4- and 6-carbamates related to physostigmine of the formula ##STR1## where R.sub.1 is alkyl, cycloalkyl, bicycloalkyl, aryl or arylloweralkyl; R.sub.2 is hydrogen or alkyl or the group --NR.sub.1 R.sub.2 taken together forms a monocyclic or bicyclic ring of 5 to 12 carbons; m is 0,1, or 2; each X is independently hydrogen, halogen, loweralkyl, nitro or amino; and the pharmaceutically acceptable acid addition salts thereof, and where applicable, the geometric and optical isomers and racemic mixtures thereof. This invention also relates to novel intermediates useful in the preparation of the 4- and 6-carbamates. The compounds of this invention display utility for alleviating various memory dysfunctions characterized by a decreased cholinergic function, such as Alzheimer's disease.
    Type: Grant
    Filed: September 3, 1991
    Date of Patent: November 9, 1993
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Edward J. Glamkowski, Barbara E. Kurys
  • Heteroaryl-8-azabicyclo[3.2.1]octanes as antipsychotic agents, 5-HT.sub.3 receptor antagonists and inhibitors of the reuptake of serotonin
    Patent number: 5234931
    Abstract: This invention relates to compounds of the formula ##STR1## where X is --O--, --S-- or --NH--;Y is hydrogen, halogen and loweralkoxy;p is 1 or 2;n is 2, 3 or 4;R is hydrogen, loweralkyl, loweralkoxy, hydroxy, halogen, amino, loweralkylamino, nitro, loweralkylthio, trifluoromethoxy, cyano, trifluoromethyl, ##STR2## R.sub.1 is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, carboxyl, loweralkylamino, nitro, loweralkylthio, cyano, and trifluoromethyl;m is 1 or 2; a pharmaceutically acceptable acid addition salt thereof and, where applicable the geometric and optical isomers and racemic mixtures thereof.The compounds and compositions of this invention are useful as antipsychotic agents, as 5-HT.sub.3 receptor antagonists and as inhibitors of the reuptake of serotonin.
    Type: Grant
    Filed: February 4, 1992
    Date of Patent: August 10, 1993
    Assignee: Hoechst-Roussel Pharmaceuticals Incorporated
    Inventors: Edward J. Glamkowski, David M. Fink, Barbara E. Kurys, Yulin Chiang
  • Benzo(b)pyrrolobenzodiazepines
    Patent number: 5189161
    Abstract: Novel benzo[b]pyrrolo[3,2,1-jk]benzodiazepines, intermediates and processes for the preparation thereof, and methods for alleviating pain utilizing the compounds or compositions thereof are disclosed.
    Type: Grant
    Filed: March 4, 1991
    Date of Patent: February 23, 1993
    Assignee: Hoechst Roussel Pharmaceuticals Inc.
    Inventors: Edward J. Glamkowski, Barbara E. Kurys
  • Memory enhancing and analgesic 1,2,3a,8,8a-hexahydro-3a,8(and 1,3a,8)-di(and tri)methylpyrrolo[2,3-b]indoles
    Patent number: 5187165
    Abstract: There are disclosed various derivatives of eseroline and related compounds of the formula below ##STR1## where R,R.sub.1, X,Z and m are as defined in the specification, which compounds being useful for enhancing cholinergic function, as antidepressant agents and as analgesic agents.
    Type: Grant
    Filed: September 22, 1988
    Date of Patent: February 16, 1993
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Russell R. L. Hamer, Grover C. Helsley, Edward J. Glamkowski, Yulin Chiang, Brian S. Freed, Barbara E. Kurys
  • 4- and 6-carbamates related to physostigmine and intermediates for the preparation thereof
    Patent number: 5081117
    Abstract: This invention relates to 4- and 6-carbamates related to physostigmine of the formula ##STR1## where R.sub.1 is alkyl, cycloalkyl, bicycloalkyl, aryl or arylloweralkyl; R.sub.2 is hydrogen or alkyl or the group --NR.sub.1 R.sub.2 taken together forms a monocyclic or bicyclic ring of 5 to 12 carbons; m is 0,1, or 2; each X is independently hydrogen, halogen, loweralkyl, nitro or amino; and the pharmaceutically acceptable acid addition salts thereof, and where applicable, the geometric and optical isomers and racemic mixtures thereof. This invention also relates to novel intermediates useful in the preparation of the 4- and 6-carbamates. The compounds of this invention display utility for alleviating various memory dysfunctions characterized by a decreased cholinergic function, such as Alzheimer's disease.
    Type: Grant
    Filed: November 3, 1989
    Date of Patent: January 14, 1992
    Assignee: Hoechst-Roussel Pharmaceuticals Incorporated
    Inventors: Edward J. Glamkowski, Barbara E. Kurys
  • Benzo(b)pyrrolobenzodiazepines
    Patent number: 5015738
    Abstract: Novel benzo[b]pyrrolo[3,2,1-jk]benzodiazepines, intermediates and processes for the preparation thereof, and methods for alleviating pain utilizing the compounds or compositions thereof are disclosed.
    Type: Grant
    Filed: September 21, 1990
    Date of Patent: May 14, 1991
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Edward J. Glamkowski, Barbara E. Kurys
  • Benzo(b)pyrrolobenzodiazepines
    Patent number: 4983601
    Abstract: Novel benzo[b]pyrrolo[3,2,1-jk]benzodiazepines, intermediates and processes for the preparation thereof, and methods for alleviating pain utilizing the compounds or compositions thereof are disclosed.
    Type: Grant
    Filed: August 7, 1989
    Date of Patent: January 8, 1991
    Assignee: Hoechst-Roussel Pharmaceutical Inc.
    Inventors: Edward J. Glamkowski, Barbara E. Kurys
  • Carbonate derivatives of eseroline
    Patent number: 4971992
    Abstract: This invention relates to 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol carbonate esters of the ##STR1## the pharmaceutically acceptable acid addition salts thereof and where applicable to the geometric and optical isomers and racemic mixtures thereof. The compounds of this invention display utility as analgesic agents.
    Type: Grant
    Filed: March 27, 1989
    Date of Patent: November 20, 1990
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Edward J. Glamkowski, Yulin Chiang, Barbara E. Kurys
  • 7H-benzo[b]pyrazino[1,2-d]pyrrolo[3,2,1-jk][1,4]benzodiazepines
    Patent number: 4929615
    Abstract: Novel 7H-benzo[b]pyrazino[1,2-d]pyrrolo[3,2,1-jk][1,4]benzodiazepines, processes for the preparation thereof, and a method of treating depression utilizing compounds or compositions thereof are disclosed.
    Type: Grant
    Filed: June 12, 1989
    Date of Patent: May 29, 1990
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Edward J. Glamkowski, Barbara E. Kurys