Abstract: Substituted 2-pyridine cyclohexane-1,4-diamine compounds, a method for their production, pharmaceutical compositions containing them, and the use of such substituted 2-pyridine cyclohexane-1,4-diamine compounds for treating pain and various other medical conditions.

Abstract: A process for the manufacture of a=:1-1,3-dihydrofuro[3,4-c]pyridine (I) 1 which is 4,7-disubstituted with a readily cleavable group (R) involves reacting a bis(3-R-substituted 2-propynyl) ether of the formula (R—C≡C—CH2)2O (II) with acetonitrile in the presence of a cobalt(I) complex catalyst of the formula XCo(I)Lig1/2 (III), wherein X signifies cyclopentadienyl, acetylcyclopentadienyl, indenyl or phenylborinato and Lig1/2 signifies the cyclooctadiene or norbornadiene ligand (Lig1) or two carbonyl or ethene ligands (Lig2), in an aliphatic, alicyclic or aromatic hydrocarbon solvent, or in excess acetonitrile as the reagent and simultaneously the solvent, or in water alone or in admixture with an ethereal co-solvent, or in a mixture of two or more of the aforementioned types of solvents, at a temperature in the range from about 0° C. to about 80° C.

Abstract: Substituted 2-pyridine cyclohexane-1,4-diamine compounds, a method for their production, pharmaceutical compositions containing them, and the use of such substituted 2-pyridine cyclohexane-1,4-diamine compounds for treating pain and various other medical conditions.