Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods for delivering therapy to an adrenal gland of a patient. The apparatuses, systems, and methods may include a plurality of stimulation elements arranged configured to deliver stimulation energy through at least one of the plurality of stimulation elements to modulate aldosterone levels within the patient.

Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods for delivering therapy to an adrenal gland of a patient. The apparatuses, systems, and methods may include a plurality of stimulation elements arranged configured to deliver stimulation energy through at least one of the plurality of stimulation elements to modulate aldosterone levels within the patient.

Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems and methods for treating an ischemic brain injury. Certain aspects include delivering the treatment substrate to a therapy region in a patient's brain. In addition, certain aspects of the disclosure can include using a number of electrodes arranged with a deep brain stimulation lead to identify the therapy region.

Abstract: A medical device for permanent implantation in a circulatory system of a patient may include an implant configured for percutaneous or minimally-invasive insertion into the patient, at least one connector fixedly attached to the implant and configured to releasably attach to a delivery device, the at least one connector being exposed to blood flow within the circulatory system following implantation, and an anti-thrombus feature configured to transition from an undeployed state to a deployed state.

Abstract: A catheter assembly includes a catheter and a delivery element. The catheter has a distal end with a distal tip, a proximal end, and a longitudinal length. The catheter includes a body that defines a central lumen extending along the catheter to the distal end. The catheter also includes a forward-facing transducer array disposed at the distal tip of the catheter. The transducer array is configured and arranged for transforming applied electrical signals to acoustic signals and also for transforming received echo signals to electrical signals. At least one catheter conductor is electrically coupled to the transducer array and extends along the catheter. The delivery element is disposed in the lumen of the catheter. The delivery element includes a distal tip that is configured and arranged for contacting patient tissue. The distal tip of the delivery element is configured and arranged to extend beyond the distal tip of the catheter.

Abstract: A guidewire system may include a tubular guidewire including at least one lumen and a plurality of apertures disposed through an outer wall, and at least one pressure wire slidably disposed within the at least one lumen, the at least one pressure wire having at least one pressure sensor disposed thereon. A method of measuring a blood pressure gradient across a treatment site may include advancing the tubular guidewire to the treatment site, positioning at least one aperture distal and at least one aperture proximal of the treatment site, translating the pressure wire within the tubular guidewire, positioning the pressure wire such that a distal pressure sensor is disposed adjacent the at least one aperture distal of the treatment site, and a proximal pressure sensor is disposed adjacent the at least one aperture proximal of the treatment site, and measuring a blood pressure gradient across the treatment site.

Abstract: A catheter assembly includes a catheter and a delivery element. The catheter has a distal end with a distal tip, a proximal end, and a longitudinal length. The catheter includes a body that defines a central lumen extending along the catheter to the distal end. The catheter also includes a forward-facing transducer array disposed at the distal tip of the catheter. The transducer array is configured and arranged for transforming applied electrical signals to acoustic signals and also for transforming received echo signals to electrical signals. At least one catheter conductor is electrically coupled to the transducer array and extends along the catheter. The delivery element is disposed in the lumen of the catheter. The delivery element includes a distal tip that is configured and arranged for contacting patient tissue. The distal tip of the delivery element is configured and arranged to extend beyond the distal tip of the catheter.

Abstract: A catheter assembly includes a catheter and a delivery element. The catheter has a distal end with a distal tip, a proximal end, and a longitudinal length. The catheter includes a body that defines a central lumen extending along the catheter to the distal end. The catheter also includes a forward-facing transducer array disposed at the distal tip of the catheter. The transducer array is configured and arranged for transforming applied electrical signals to acoustic signals and also for transforming received echo signals to electrical signals. At least one catheter conductor is electrically coupled to the transducer array and extends along the catheter. The delivery element is disposed in the lumen of the catheter. The delivery element includes a distal tip that is configured and arranged for contacting patient tissue. The distal tip of the delivery element is configured and arranged to extend beyond the distal tip of the catheter.

Abstract: A porous, water-absorbing fleece is made from crosslinkable biocompatible and biodegradable macromers. A solution of the macromers is frozen and vacuum-dried through lyophilization. The “fleece” formed by lyophilization is then crosslinked, for example by heat and/or an initiator of crosslinking. The resulting crosslinked material is highly water absorbent, readily swelling to at least its size before lyophilization, but retains macroporosity as well as the microporosity of a gel. Porosity and strength of the fleece can be controlled by initial polymer concentration and extent of crosslinking. The fleece materials can be used in different embodiments for applications in medicine and tissue engineering.