Patents by Inventor Barbara J. England

Barbara J. England has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and reagents for the rapid determination of glycated hemoglobin
    Patent number: 5686316
    Abstract: The invention is a rapid, continuous test for glycated hemoglobin using a non-equilibrium affinity binding method. Agarose beads derivatized with 3-aminophenylboronic acid specifically bind glycated hemoglobin. This solid phase is incorporated into a sample processor card, modified to mix and to separate the test solution from the solid phase prior to absorbance readings. Two absorbance readings are made on the test solution, one immediately after mixing the reagent/diluent with the specimen, and one after a significant amount of binding has occurred. A linear correlation between total glycated hemoglobin and hemoglobin A.sub.1c permits standardization and reporting of units equivalent to % hemoglobin A.sub.1c. Stable glycated hemoglobin solutions for use as standards in the assay, and a method for preparing the standards are also disclosed.
    Type: Grant
    Filed: April 28, 1995
    Date of Patent: November 11, 1997
    Assignee: Abbott Laboratories
    Inventors: Michael D. Fiechtner, John M. Ramp, Barbara J. England, Mary J. Annino
  • Method for preparing a glycated hemoglobin solution
    Patent number: 5589393
    Abstract: The invention is a rapid, continuous test for glycated hemoglobin using a non-equilibrium affinity binding method. Agarose beads derivatized with 3-aminophenylboronic acid specifically bind glycated hemoglobin. This solid phase is incorporated into a sample processor card, modified to mix and to separate the test solution from the solid phase prior to absorbance readings. Two absorbance readings are made on the test solution, one immediately after mixing the reagent/diluent with the specimen, and one after a significant amount of binding has occurred. A linear correlation between total glycated hemoglobin and hemoglobin A.sub.1c permits standardization and reporting of units equivalent to % hemoglobin A.sub.1c. Stable glycated hemoglobin solutions for use as standards in the assay, and a method for preparing the standards are also disclosed.
    Type: Grant
    Filed: April 24, 1995
    Date of Patent: December 31, 1996
    Assignee: Abbott Laboratories
    Inventors: Michael D. Fiechtner, John M. Ramp, Barbara J. England, Mary J. Annino
  • Stabilized bilirubin calibrator solution and method therefor
    Patent number: 5401639
    Abstract: A stabilized anoxic diagnostic reagent solution comprising an oxygen labile reagent, glucose oxidase, glucose, a hydrogen donor, sterile membrane fragments derived from bacteria having membranes containing an oxygen transfer system, and a reagent binding agent. The stabilized reagent has at least six months storage stability at 2.degree.-8.degree. C. and open vial stability of at least three weeks.
    Type: Grant
    Filed: August 25, 1992
    Date of Patent: March 28, 1995
    Assignee: Abbott Laboratories
    Inventors: Louis Saldivar, Jr., Barbara J. England