Patents by Inventor Barbara Johnson SASU

Barbara Johnson SASU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • T CELL RECEPTOR KNOCK OUT ENGINEERED IMMUNE CELLS, ENDOWED WITH CHIMERIC ANTIGEN RECEPTORS BINDING TO CD123 FOR THE TREATMENT OF RELAPSED/REFRACTORY ACUTE MYELOID LYMPHOMA OR BLASTIC PLASMACYTOID DENDRITIC CELL NEOPLASM
    Publication number: 20180051089
    Abstract: The present invention relates to a TCR KO—or TCR KO and dCK KO—engineered immune cells expressing a Chimeric Antigen Receptors (CAR) specific for CD123 that is a recombinant chimeric protein able to redirect immune cell specificity and reactivity toward CD123-expressing cells, and more particularly in which extracellular ligand binding is a scFV derived from a CD123 monoclonal antibody, conferring specific immunity against CD123 positive cells. The engineered immune cells endowed with such CD123 CARs are particularly suited for treating relapse refractory AML and blastic plasmacytoid dendritic cell neoplasm and for use as a treatment before bone marrow transplantation.
    Type: Application
    Filed: January 25, 2016
    Publication date: February 22, 2018
    Inventors: Roman GALETTO, Barbara Johnson SASU, Arvind RAJPAL, Philippe DUCHATEAU, Alexandre JUILLERAT, Julien VALTON, Mathieu SIMON
  • mAb-DRIVEN CHIMERIC ANTIGEN RECEPTOR SYSTEMS FOR SORTING/DEPLETING ENGINEERED IMMUNE CELLS
    Publication number: 20180002435
    Abstract: A polypeptide encoding a chimeric antigen receptor (CAR) comprising at least one extracellular binding domain that comprises a scFv formed by at least a VH chain and a VL chain specific to an antigen, wherein said extracellular binding domain comprises at least one mAb-specific epitope.
    Type: Application
    Filed: January 25, 2016
    Publication date: January 4, 2018
    Inventors: Barbara Johnson SASU, Arvind RAJPAL, Philippe DUCHATEAU, Alexandre JUILLERAT, Julien VALTON