Patents by Inventor Barbara Klein

Barbara Klein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11958016
    Abstract: Dialysis devices include a frame defined by a plurality of sidewalls that are impermeable to a sample being dialyzed, a pair of dialysis membranes that are each associated with an opposing face of the plurality of sidewalls such that the plurality of sidewalls and the pair of dialysis membranes define a sample chamber, an outer shell surrounding at least a portion of the pair of dialysis membranes, and a cap selectively associated with the sample chamber. The cap can be selectively associated with the sample chamber via an attachment mechanism that is configured to provide aural and/or haptic feedback when the cap forms a tight association with the sample chamber. The cap can be a sensor cap having one or more probes for measuring at least one property of fluid inside and/or outside the sample chamber and a transmitter for transmitting data captured at the probe(s) to a destination device.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: April 16, 2024
    Assignees: Pierce Biotechnology, Inc., Life Technologies Corporation
    Inventors: Kay Opperman, Barbara Kaboord, Aaron McBride, Greg Nagy, Sandro Klein, Joanna Geddes
  • Publication number: 20090171590
    Abstract: The invention encompasses analyzers and analyzer systems that include a single particle analyzer, methods of using the analyzers and analyzers systems to analyze samples, either for single particles or for multiple particles (multiplexing), methods of doing business based on the use of the analyzers or analyzer systems of the system, and electronic media for storing parameters useful in the analyzers and analyzer systems of the invention.
    Type: Application
    Filed: November 21, 2008
    Publication date: July 2, 2009
    Inventors: Robert PUSKAS, Richard A. Livingston, Douglas D. Held, Barbara Klein, Neolle Fukushima, Robert Freese, Philippe J. Goix, Peter R. David, Mickey Urdea
  • Publication number: 20080158543
    Abstract: The invention encompasses analyzers and analyzer systems that include a single particle analyzer, methods of using the analyzers and analyzers systems to analyze samples, either for single particles or for multiple particles (multiplexing), methods of doing business based on the use of the analyzers or analyzer systems of the system, and electronic media for storing parameters useful in the analyzers and analyzer systems of the invention.
    Type: Application
    Filed: August 13, 2007
    Publication date: July 3, 2008
    Inventors: Robert Puskas, Richard A. Livingston, Douglas D. Held, Barbara Klein, Noelle Fukushima, Robert Freese, Philippe J. Goix, Peter R. David, Mickey Urdea
  • Publication number: 20060240083
    Abstract: A medical composition comprising an antimicrobially effective and immunostimulating amount of a combination of a ?-glucan component and a silver-containing component is disclosed. The medical composition may be adapted for use topically or incorporated with a mesh material which may be further adapted for use as a wound dressing or as a surgical mesh. Methods for manufacturing the medical compositions described herein are also provided. The invention further provides methods for treating tissue damaged by wound or burn, and methods for treating or repairing tissue at a surgical site.
    Type: Application
    Filed: July 6, 2006
    Publication date: October 26, 2006
    Applicant: BRENNEN MEDICAL, LLC
    Inventors: Barbara Klein, Leo Katzner
  • Publication number: 20060078998
    Abstract: The invention encompasses analyzers and analyzer systems that include a single particle analyzer, methods of using the analyzers and analyzers systems to analyze samples, either for single particles or for multiple particles (multiplexing), methods of doing business based on the use of the analyzers or analyzer systems of the system, and electronic media for storing parameters useful in the analyzers and analyzer systems of the invention.
    Type: Application
    Filed: January 28, 2005
    Publication date: April 13, 2006
    Inventors: Robert Puskas, Richard Livingston, Douglas Held, Barbara Klein, Noelle Fukushima, Robert Freese, Philippe Goix, Peter David, Mickey Urdea
  • Publication number: 20050244372
    Abstract: The present invention relates to recombinant human interleukin-3 (hIL-3) variant or mutant proteins (muteins). These hIL-3 muteins contain amino acid substitutions and may also have amino acid deletions at both the N- and C-termini. The invention also relates to pharmaceutical compositions containing the hIL-3 muteins and methods for using them. Additionally, the present invention relates to recombinant expression vectors comprising nucleotide sequences encoding the hIL-3 muteins, related microbial expression systems, and processes for making the hIL-3 muteins using the microbial expression systems. Included in the present invention are deletion mutants of hIL-3 in which from 1 to 14 amino acids have been deleted from the N-terminus, and from 1 to 15 amino acids 119 to 133 have been deleted from the C-terminus, and which also contain amino acid substitutions in the polypeptide.
    Type: Application
    Filed: May 13, 2004
    Publication date: November 3, 2005
    Inventors: S. Bauer, Mark Abrams, Sarah Braford-Goldberg, Maire Caparon, Alan Easton, Barbara Klein, John McKearn, Peter Olins, Kumnan Paik, John Thomas
  • Publication number: 20050059149
    Abstract: The present invention relates to methods of ex-vivo expansion of hematopoietic cells by culturing hematopoietic cells in a growth medium comprising a chimera protein which comprises a variant of human interleukin-3 (hIL-3) which contains multiple amino acid substitutions and which may have portions of the native hIL-3 molecule deleted and a hematopoietic growth factor. The present invention also relates to the ex-vivo expansion of hematopoietic cells for gene therapy. Additionally, the present invention relates to the use of the expanded hematopoietic cells for treating patients having a hematopoietic disorder.
    Type: Application
    Filed: September 22, 2004
    Publication date: March 17, 2005
    Inventors: S. Bauer, Mark Abrams, Sarah Braford-Goldberg, Maire Caparon, Alan Easton, Barbara Klein, John McKearn, Peter Olins, Kumnan Paik, John Thomas
  • Publication number: 20050037439
    Abstract: The invention relates nucleic acids and their encoded polypeptides, whose expression is modulated in cancer or tumor cells. The invention further relates to methods useful for treating or modulating cancer or tumors in mammals in need of such biological effect. This includes the diagnosis and treatment of oncological disorders. Additionally, the present invention further relates to the use of antibodies against the polypeptides of the present invention as diagnostic probes or as therapeutic agents as well as the use of polynucleotide sequences encoding the polypeptides of the present invention as diagnostic probes or therapeutic agents for the treatment of a broad range of pathological states.
    Type: Application
    Filed: October 29, 2003
    Publication date: February 17, 2005
    Inventors: Maureen Bourner, Paul Hippenmeyer, Richard Head, Richard Mazzarella, Nicholas Staten, Barbara Klein
  • Patent number: 6713114
    Abstract: The invention relates to a frozen beverage topping composition which provides a frothy or foam layer to a beverage. The beverage topping composition provides creaming and can flavor, sweeten, and slightly cool coffee and other beverages. The frozen beverage topping composition of the invention may be made in non-dairy, dairy (containing non-fat dry milk and non-dairy fat), and real dairy (containing non-fat dry mile and butterfat) forms, as well as caloric and non-caloric sweetened versions. Methods of producing the frozen beverage topping composition are provided as well as methods of using the frozen beverage topping compositions.
    Type: Grant
    Filed: February 14, 2001
    Date of Patent: March 30, 2004
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Barbara Klein, James Faller, Teresa Paeschke, Eleftherios Moros, Jennifer Grady, Maureen Cheng, Glinda Lofton, Lynn Magden, Nicole Romero
  • Publication number: 20030194783
    Abstract: The present invention relates to human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally co-administered with a other colony stimulating factors (CSF), cytokines, lymphokines, interleukins, hematopoietic growth factors or IL-3 variants.
    Type: Application
    Filed: February 8, 2002
    Publication date: October 16, 2003
    Inventors: John P. McKearn, Peter Olins, John Thomas, Maire Caparon, Alan Easton, Barbara Klein, S. Christopher Bauer, Mark Abrams, Kumnan Paik, Sarah Braford-Goldberg
  • Patent number: 6541678
    Abstract: The present invention discloses an immunostimulating agent that may be applied to various surgical devices to promote rapid healing and the ready acceptance and integration of the surgical devices with the body tissues at the surgical site.
    Type: Grant
    Filed: March 21, 2001
    Date of Patent: April 1, 2003
    Assignee: Brennen Medical, Inc.
    Inventor: Barbara Klein
  • Publication number: 20020197355
    Abstract: The invention relates to a frozen beverage topping composition which provides a frothy or foam layer to a beverage. The beverage topping composition provides creaming and can flavor, sweeten, and slightly cool coffee and other beverages. The frozen beverage topping composition of the invention may be made in non-dairy, dairy (containing non-fat dry milk and non-dairy fat), and real dairy (containing non-fat dry mile and butterfat) forms, as well as caloric and non-caloric sweetened versions. Methods of producing the frozen beverage topping composition are provided as well as methods of using the frozen beverage topping compositions.
    Type: Application
    Filed: February 14, 2001
    Publication date: December 26, 2002
    Inventors: Barbara Klein, James Faller, Teresa Paeschke, Eleftherios Moros, Jenniefer Grady, Maureen Cheng, Glinda Lofton, Lynn Magedn, Nicole Romero
  • Publication number: 20020055697
    Abstract: The present invention discloses an immunostimulating agent that may be applied to various surgical devices to promote rapid healing and the ready acceptance and integration of the surgical devices with the body tissues at the surgical site.
    Type: Application
    Filed: March 21, 2001
    Publication date: May 9, 2002
    Inventor: Barbara Klein
  • Patent number: 6379662
    Abstract: The present invention relates to human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally co-administered with a other colony stimulating factors (CSF), cytokines, lymphokines, interleukins, hematopoietic growth factors or IL-3 variants.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: April 30, 2002
    Inventors: John P. McKearn, Peter Olins, John Thomas, Maire Caparon, Alan Easton, Barbara Klein, S. Christopher Bauer, Mark Abrams, Kumnan Paik, Sarah Braford-Goldberg
  • Patent number: 6358505
    Abstract: Disclosed are novel G-CSF receptor agonist proteins, DNAs which encode the multi-functional hematopoietic receptor agonists proteins, methods of making the multi-functional hematopoietic receptor agonists proteins and methods of using the multi-functional hematopoietic receptor agonists proteins.
    Type: Grant
    Filed: June 25, 1999
    Date of Patent: March 19, 2002
    Inventors: Linda Zurfluh, Barbara Klein, Charles McWherter, Yiping Feng, John McKearn, Sarah Braford-Goldberg
  • Patent number: 6133506
    Abstract: Promoters in the 5' non-translated region of genes from Cuphea lanceota that code for .beta.-ketoacyl-(ACP) reductase are disclosed, as well as alleles and derivatives of said promoters. These promoters in the 5' non-translated region may for example be coupled with foreign genes, forming chimeric genes, and be transmitted to plants in appropriate vector systems.
    Type: Grant
    Filed: May 23, 1996
    Date of Patent: October 17, 2000
    Assignee: Max-Planck-Gesellschaft zur Forerung Der Wissenschaft E.V.
    Inventors: Reinhard Topfer, Christa Horicke-Grandpierre, Barbara Klein, Jeff Schell