Abstract: A method of modifying antigen-presenting cells is described, in which antigens of diseased cells or their cell components are transferred to the antigen-presenting cells, the antigen-presenting cells being brought into contact with the diseased cells or their cell components on a solid-phase substrate or in a suspension through introduction into a shared suspension and exertion of external forces, membrane components having antigens without cell nuclei of the diseased cells or their cell components being transferred to the antigen-presenting cells and subsequently a separation of the modified cells from the solid-phase substrate or from the suspension being performed.