Abstract: This disclosure describes systems, methods, and devices related to providing real-time response strategies in a supply chain. A system may be configured to obtain first sensor data collected from a first tracking device associated with a first asset, determine a first set of external data associated with the first asset, determine, based at least in part on the first sensor data and the first set of external data, a probability of failure and a mode of failure, and responsive to a determination that the probability of failure exceeds a failure threshold: determine a mitigation for the mode of failure that is available based at least in part on the first sensor data and the first set of external data, determine one or more real-world actions corresponding to the mitigation that, if performed, remediate the mode of failure, and cause the one or more real-world actions to be performed.

Abstract: This disclosure describes systems, methods, and devices related to programmatically updating the status of assets tracked in a supply chain environment. A system may be configured to obtain first sensor data collected from a first tracking device associated with a first asset, determine asset workflow information associated with the first asset, determine an intelligence engine configured to generate an inference of a status associated with the first asset, determine the status associated with the first asset, wherein the status is determined by the intelligence engine based on the first sensor data and the asset workflow information, and store the status of the first asset in an asset tracking database.

Abstract: Systems and methods for real time laparoscopic navigation. Exemplary embodiments can comprise scanning a structure of interest internal to a patient to provide image data; generating a first three-dimensional reconstruction of the structure of interest based on the image data; annotating the first three-dimensional reconstruction of the structure of interest with a plurality of reference points; obtaining spatial coordinates of the plurality of reference points during a laparoscopic procedure; and generating a second three-dimensional reconstruction of the structure of interest based on the spatial coordinates.

Abstract: Systems and methods for monitoring medical procedures. Particular embodiments relate to monitoring medical procedures performed in operating room environments through the use of various types of sensors.

Abstract: Systems and methods for tracking a surgical tool. Exemplary embodiments can comprise a surgical port, a tracking element configured for coupling to a surgical tool, and a camera mounted to a proximal end of the surgical port and configured to capture image data associated with the tracking element.

Abstract: A mobile computing system comprises a mobile computing device comprising a first hook and loop material secured to a back of the mobile computing device using a first adhesive. The hook and loop material covering a majority portion of the back of the mobile computing device and extending across the back of mobile computing device from a first side to a second side and covering a majority portion of at least the first side. A stylus associated with the mobile computing device comprising a second hook and loop material forming a tube with the stylus inserted therein and secured to the stylus using a second adhesive, said hook and loop material covering a majority of the stylus. The first and second first hook and loop material engaged when the stylus makes contact with the mobile computing device for secured storage when not in use.

Abstract: Systems and methods for determining a position of a surgical tool. Exemplary embodiments can comprise a surgical port, a reference marker, and a camera mounted to a proximal end of the surgical port and configured to capture image data associated with the reference marker.

Abstract: Reminders are provided to a user. A particular reminder for the user and a confidence level associated with the particular reminder are input. A current priority level for the particular reminder is then computed, where this computation is based on reminder prioritization factors that include this confidence level, a current context for the user, and additional information about this current context. One or more user notification methods for providing the particular reminder to the user are then selected, where this selection is based on notification method selection factors that include the computed current priority level for the particular reminder, the current context for the user, and the additional information about this current context. The selected user notification methods are then utilized to provide the particular reminder to the user.

Abstract: Systems and methods for monitoring medical procedures. Particular embodiment's relate to monitoring medical procedures performed in operating room environments through the use of various types of sensors, including for example, wireless electroencephalography (EEG) monitoring systems. Presented are systems and methods directed to a monitor medical procedures, including in particular the mental state of medical personnel associated with such procedures. Exemplary embodiment's of the present disclosure relate to systems and methods for monitoring medical procedures. Particular embodiment's relate to monitoring medical procedures performed in operating room environments through the use of various types of sensors, including for example, wireless electroencephalography (EEG) monitoring systems.

Abstract: Disclosed herein are methods and compositions for the treatment of diseases of the CNS with nucleic acid nanoparticles. Compositions are also disclosed herein that utilize nucleic acid nanoparticles to treat conditions such as Parkinson's Disease. Furthermore, methods of intranasally administering the compacted nucleic acid nanoparticles for therapeutic purposes in the brain are disclosed.

Abstract: Systems and methods for monitoring medical procedures. Particular embodiments relate to monitoring medical procedures performed in operating room environments through the use of various types of sensors.

Abstract: Systems and methods for determining a position of a surgical tool. Exemplary embodiments can comprise a surgical port, a reference marker, and a camera mounted to a proximal end of the surgical port and configured to capture image data associated with the reference marker.

Abstract: Systems and methods for real time laparoscopic navigation. Exemplary embodiments can comprise scanning a structure of interest internal to a patient to provide image data; generating a first three-dimensional reconstruction of the structure of interest based on the image data; annotating the first three-dimensional reconstruction of the structure of interest with a plurality of reference points; obtaining spatial coordinates of the plurality of reference points during a laparoscopic procedure; and generating a second three-dimensional reconstruction of the structure of interest based on the spatial coordinates.

Abstract: Disclosed herein are methods and compositions for the treatment of diseases of the CNS with nucleic acid nanoparticles. Compositions are also disclosed herein that utilize nucleic acid nanoparticles to treat conditions such as Parkinson's Disease. Furthermore, methods of intranasally administering the compacted nucleic acid nanoparticles for therapeutic purposes in the brain are disclosed.

Abstract: A system for associating a non-linear video path with a video file includes: a controller adapted to: present a video file through the user interface; receive a command through the user interface to associate a first path point with a frame in the video file; receive a command through the user interface to associate a second path point with a second frame in the video file; receive a command through the user interface to associate a third path point with a third frame in the video file, wherein the first path point, second path point, and third path point define a non-linear path, wherein the non-linear path is associated with the video file such that, when presented to a user for playback through a device that receives user input, progress of the video file during playback is controlled by one or more user inputs related to the non-linear path.

Abstract: Systems and methods for tracking a surgical tool. Exemplary embodiments can comprise a surgical port, a tracking element configured for coupling to a surgical tool, and a camera mounted to a proximal end of the surgical port and configured to capture image data associated with the tracking element.

Abstract: A system for associating a non-linear video path with a video file includes: a controller adapted to: present a video file through the user interface; receive a command through the user interface to associate a first path point with a frame in the video file; receive a command through the user interface to associate a second path point with a second frame in the video file; receive a command through the user interface to associate a third path point with a third frame in the video file, wherein the first path point, second path point, and third path point define a non-linear path, wherein the non-linear path is associated with the video file such that, when presented to a user for playback through a device that receives user input, progress of the video file during playback is controlled by one or more user inputs related to the non-linear path.

Abstract: This invention provides a crayon of special external configuration arranged to facilitate the training and development of a tripod grip in the use of pencils, pens and the like. The crayon has a body which has convexly curved end portions and at least first, second and third surfaces which are defined intermediate the body end portions in such manner as to impart to the body a generally triangular transverse cross-sectional shape of a location substantially centrally between the body and portions. Those surfaces converge toward one of the body end portions. The intersections of at least two of the surfaces with each and with the body end portions are smoothly convexly curved.

Abstract: Methods for treating a headache, such as a migraine, in a subject comprising administering a therapeutically effective amount of an adipocytokine, for example, adiponectin, to the subject are disclosed. Pharmaceutical compositions comprising adipocytokine, for example, adiponectin, are disclosed. Methods of diagnosing the presence or absence of a headache in a subject, such as a migraine, by assessing the level of adiponectin in the subject are disclosed.