Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: An enamel bead-making system involves a novel bead-pulling station and a mandrel (slender rod). The mandrel is for manually dipping a preheated metal bead core into a container of glass powder so that the powder melts and later solidifies on the core, thereby creating an enamel or glass coated bead. To safely remove the hot enamel bead from the mandrel, the mandrel is manually pulled through a V-notch in an upper edge of the bead-pulling station, which forces the bead off the end of the mandrel and into a collection area for cooling. A second V-notch allows a subsequent bead to be removed and cooled at a location spaced apart from the first one. If a bead sticks on the mandrel, the mandrel can be pushed through a small hole in the bead-pulling station, which helps break a glass bond that might develop between the mandrel and the enamel bead.