Abstract: The present invention provides a method of assessing the glucocorticoid receptor signalling pathway modulated by a test compound comprising; (a) providing a cell having a first polynucleotide construct comprising a first reporter gene under the control of a first promoter indicative of a first glucocorticoid receptor signalling pathway; (b) providing a second cell of the same lineage as the cell (a), and comprising a second polynucleotide construct having a second reporter gene under the control of a second promoter indicative of a second glucocorticoid receptor signalling pathway; (c) incubating said first and second cells with a test compound; (d) monitoring for expression of the first and second reporter genes.