Patents by Inventor Barbara Mohar

Barbara Mohar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of enantiomerically enriched proton pump inhibitors
    Patent number: 8889873
    Abstract: The invention discloses a process for the preparation of compounds having structures typical for proton pump inhibitors in enantiomerically enriched form by using particular metal catalysts in an enantioselective oxidation step. Also disclosed are useful further processes and pure intermediate and subsequently final products.
    Type: Grant
    Filed: October 13, 2009
    Date of Patent: November 18, 2014
    Assignee: LEK Pharmaceuticals D.D.
    Inventors: Barbara Mohar, Renata Toplak Casar
  • PROCESS FOR THE PREPARATION OF EZETIMIBE AND DERIVATIVES THEREOF
    Publication number: 20130190487
    Abstract: The present invention relates to the method of preparing of ezetimibe and in particular to novel intermediates for its synthesis and an improved process for preparing such intermediates. Said intermediates may be obtained in high yields and purity in a fast and cost efficient manner. The present invention relates to a novel crystalline form of ezetimibe as well.
    Type: Application
    Filed: January 24, 2008
    Publication date: July 25, 2013
    Applicant: KRKA
    Inventors: Anton Stimac, Barbara Mohar, Michel Stephan, Mojca Bevc, Rok Zupet, Andrej Gartner, Vesna Kroselj, Matej Smrkolj, Davor Kidemet, Gregor Sedmak, PRIMOZ BENKIC, ALEN KLJAJIC, MIHA PLEVNIK
  • PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED PROTON PUMP INHIBITORS
    Publication number: 20120046319
    Abstract: The invention discloses a process for the preparation of compounds having structures typical for proton pump inhibitors in enantiomerically enriched form by using particular metal catalysts in an enantioselective oxidation step. Also disclosed are useful further processes and pure intermediate and subsequently final products.
    Type: Application
    Filed: October 13, 2009
    Publication date: February 23, 2012
    Inventors: Barbara Mohar, Renata Toplak Casar
  • NEW TRINEM ANTIBIOTICS AND INHIBITORS OF BETA-LACTAMASES
    Publication number: 20110166118
    Abstract: The present invention relates to a compound of Formula (I) in particular compounds of formula (Ia), the use of a therapeutically effective amount of one or more compounds of formula (I) or (Ia) as a broad-spectrum antibiotic and the use of a pharmaceutical composition comprising said compounds for the treatment of bacterial infections in humans or animals.
    Type: Application
    Filed: June 18, 2009
    Publication date: July 7, 2011
    Applicant: LEK PHARMACEUTICALS D.D.
    Inventors: Ivan Plantan, Andrej Prezelj, Uros Urleb, Barbara Mohar, Michel Stephan
  • Form of a benzenesulfonamide derivative
    Patent number: 7868174
    Abstract: The present disclosure relates to an improved process for the preparation of enantiomerically enriched alcohols of Formula (I), from the corresponding ketone of Formula (II), by asymmetric transfer hydrogenation, using a hydrogen donor, catalyzed by a ruthenium or rhodium complex of an optically active N-sulfamoyl-1,2-diamine. R is as defined herein.
    Type: Grant
    Filed: July 21, 2005
    Date of Patent: January 11, 2011
    Assignee: Pliva-Istrazivanje I Razvoj d.o.o.
    Inventors: Amir Avdagic, Barbara Mohar, Damjan Sterk, Michel Stephan
  • NEW ORTHO-FUNCTIONALIZED P-CHIRAL ARYLPHOSPHINES AND DERIVATIVES: THEIR PREPARATION AND USE IN ASYMMETRIC CATALYSIS
    Publication number: 20100099875
    Abstract: The invention relates to novel organo phosphorus P-chiral optically active compounds of formula (I) having a hydroxyl, mercapto, amino, carboxyl, sulfonyl group on aryl near a phosphorus atom, to the preparation and the use thereof in then asymmetrical catalysis of unsaturated compounds. Novel acylphosphine optically pure ligands embodied in the form of transition metal complexes exhibit an increased activity and enantloselectivity, in particular in asymmetrical hydrogenation, in comparison with the same type Uganda such as DiPAMP.
    Type: Application
    Filed: June 20, 2006
    Publication date: April 22, 2010
    Applicants: PHOSPHOENIX SARL, NATIONAL INSTITUTE OF CHEMISTRY
    Inventors: Michel Stephan, Barbara Mohar
  • Synthesis of optically pure(r)-5-(2-amynopropyl)-2-methoxybenzenesulphonamide
    Patent number: 7538246
    Abstract: The present invention relates to a new process for the preparation of optically pure(R)-5-(2-aminopropyl)-2-methoxybenzenesulphonamide, which is an intermediate in the synthesis of tamsulosin.
    Type: Grant
    Filed: December 27, 2004
    Date of Patent: May 26, 2009
    Assignee: Lek Pharmaceuticals d.d.
    Inventor: Barbara Mohar
  • Process and intermediates for the preparation of olanzapine
    Patent number: 7498433
    Abstract: The invention provides an improved process for preparing Olanzapine as well as intermediates therefor.
    Type: Grant
    Filed: January 16, 2004
    Date of Patent: March 3, 2009
    Assignee: KRKA, Tovarna Zdravil, D.D.
    Inventors: Roman Lenarsic, Rok Zupet, Milena Benedik, Barbara Mohar, Anton {hacek over (S)}timac
  • Novel Form of a Benzenesulfonamide Derivative
    Publication number: 20080009629
    Abstract: The present disclosure relates to an improved process for the preparation of enantiomerically enriched alcohols of Formula (I), from the corresponding ketone of Formula (II), by asymmetric transfer hydrogenation, using a hydrogen donor, catalyzed by a ruthenium or rhodium complex of an optically active N-sulfamoyl-1,2-diamine. R is as defined herein.
    Type: Application
    Filed: July 21, 2005
    Publication date: January 10, 2008
    Applicant: Pliva-Istrazivanje I Razvoj d.o.o.
    Inventors: Amir Avdagic, Barbara Mohar, Damjan Sterk, Michel Stephan
  • Synthesis of optically pure(r)-5-(2-amynopropyl)-2-methoxybenzenesulphonamide
    Publication number: 20070155989
    Abstract: The present invention relates to a new process for the preparation of optically pure (R)-5-(2-aminopropyl)-2-methoxybenzenesulphonamide, which is an intermediate in the synthesis of tamsulosin.
    Type: Application
    Filed: December 27, 2004
    Publication date: July 5, 2007
    Inventor: Barbara Mohar
  • Process and intermediates for the preparation of olanzapine
    Publication number: 20060040921
    Abstract: The invention provides an improved process for preparing Olanzapine as well as intermediates therefor.
    Type: Application
    Filed: January 16, 2004
    Publication date: February 23, 2006
    Applicant: KRKA, Tovarna Zdravil D.D.
    Inventors: Roman Lenarsic, Rok Zupet, Milena Benedik, Barbara Mohar, Anton Stimac