Patents by Inventor Barbara Polski

Barbara Polski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prognosis and monitoring of membranous nephropathy based on the analysis of PLA2R1 epitope profile and spreading
    Patent number: 10739356
    Abstract: Disclosed is a method for assessing the prognosis of idiopathic membranous nephropathy in a body fluid sample from a human subject, based on profiling PLA2R1 epitopes recognized by autoantibodies in the sample. The method further relates to analysis of PLA2R1 epitope spreading amongst three PLA2R1 domains (Cys R, CTLD1 and CTLD7) that are recognized by anti-PLA2R1 autoantibodies, two of which (CTLD1 and CTLD7) are more closely associated with active idiopathic membranous nephropathy and likely linked by a mechanism of epitope spreading.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: August 11, 2020
    Assignees: Université de Nice Sophia Antipolis, Centre National de la Recherche Scientifique (CNRS), CHU de Nice
    Inventors: Vincent Louis Marie Esnault, Barbara Polski, Gérard Jean Frantz Lambeau, Guillaume Dolla
  • PROGNOSIS AND MONITORING OF MEMBRANOUS NEPHROPATHY BASED ON THE ANALYSIS OF PLA2R1 EPITOPE PROFILE AND SPREADING
    Publication number: 20180203020
    Abstract: The invention relates to a method for assessing the prognosis of idiopathic membranous nephropathy in a subject, based on the analysis of PLA2R1 epitope profile. The invention further relates to a method for monitoring the progression of idiopathic membranous nephropathy based on the analysis of the PLA2R1 epitope spreading. The invention highlights that three PLA2R1 domains (Cys R, CTLD1 and CTLD7) are involved in anti-PLA2R1 activity, with two of them (CTLD1 and CTLD7) more closely associated with active idiopathic membranous nephropathy and likely linked by a mechanism of epitope spreading.
    Type: Application
    Filed: July 8, 2016
    Publication date: July 19, 2018
    Inventors: Vincent Louis Marie Esnault, Barbara Polski, Gérard Jean Frantz Lambeau, Guillaume Dolla