Abstract: The invention relates to systems and methods for diagnosis-lifecycle management using longitudinal clinical and genomic data. The system retrieves clinical and genomic information, forms a longitudinal data record, and normalizes the data to an ontology such that diagnoses, medications, and genomic annotations are codified for analysis. For each diagnosis, the system defines a diagnosis lifecycle object having states including a baseline state, an active treatment state, and a managed state. A baseline is established from longitudinal patient data, and variances are detected by comparing protocol behaviors and rule-based thresholds with actual patient data. Treatment response is evaluated using a rule-based lifecycle model that incorporates adherence state transitions and clinical or genomic indicators, and the diagnosis lifecycle object is transitioned to a corresponding lifecycle state. Advantageously, the system may improve treatment assessment, monitoring, and clinical decision support across diagnoses.

Abstract: The invention relates generally to medication therapy and more particularly to a system and methods for medication therapy management to support improved adherence and alert clinicians of changes in behavior or symptoms. The system may facilitate interactions between various data sources (e.g., medical health records, genomics databases, and other connected third-party devices) to manage workflow, execute rules, interface with knowledge bases, codify information, schedule events, provide notification, and more. In addition, the system may include a conversational or actionable artificial intelligence persona tailored to each user and configured to, for example, converse, instruct, and/or coach a user according to one or more features of the system.

Abstract: The invention relates generally to medication therapy and more particularly to a system and methods for medication therapy management to support improved adherence and alert clinicians of changes in behavior or symptoms. The system may facilitate interactions between various data sources (e.g., medical health records, genomics databases, and other connected third-party devices) to manage workflow, execute rules, interface with knowledge bases, codify information, schedule events, provide notification, and more. In addition, the system may include a conversational or actionable artificial intelligence persona tailored to each user and configured to, for example, converse, instruct, and/or coach a user according to one or more features of the system.

Abstract: This invention relates to the field of medical informatics, and more particularly to a system and methods for generating and displaying a user interface of a patient medical record such that a user can annotate, augment, and overall interact with clinically more accurate and detailed medical information. In addition, the system may be configured to collect, display, and model an individual's genomic makeup, physiological characteristics, healthcare history, and lifestyle to enable personalized medicine, better understand the transition from health to disease, and identify additional risk factors for disease. Advantageously, the system is configured to collect, display, and model an individual's genomic makeup, health status, health history, and social determinants of health to enable personalized medicine, better understand the transition from health to disease, and identify additional risk factors for disease.

Abstract: The present invention relates to a system and methods for displaying genomic and clinical information. More specifically, the invention is directed to a system for collecting, displaying, and modeling an individual's genomic makeup, physiological characteristics, healthcare history, and lifestyle to enable personalized medicine, better understand the transition from health to disease, and identify additional risk factors for disease. Certain embodiments of the system facilitate generating and displaying a patient record on a graphical user interface. Additionally, embodiments of the invention allow users through the use of user interface to annotate, augment, and overall interact with the clinically more accurate and detailed user interface.