Patents by Inventor Barbara Savoldo

Barbara Savoldo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREATMENT OF CD30-POSITIVE CANCER
    Publication number: 20230263890
    Abstract: Methods for treating a CD30-positive cancer in a subject are disclosed, wherein the methods comprise administering a lymphodepleting chemotherapy and CD30-specific chimeric antigen receptor (CAR)-expressing cells.
    Type: Application
    Filed: June 4, 2021
    Publication date: August 24, 2023
    Applicants: Tessa Therapeutics Ltd., The University of North Carolina at Chapel Hill
    Inventors: Aung Myo, Ivan David Horak, Jonathan Serody, Gianpietro Dotti, Barbara Savoldo
  • SURVIVIN SPECIFIC T-CELL RECEPTOR TARGETING TUMOR BUT NOT T CELLS
    Publication number: 20170335290
    Abstract: Embodiments of the disclosure concern engineered T cell receptors that are specific for the survivin tumor antigen but do not have “on-target off tumor” toxicity. In particular embodiments, particular alpha and beta chains are utilized in engineered T cell receptors for cell therapy that have effective anti-tumor activity but lack fratricidal effects. Methods, compositions, and kits are provided herein.
    Type: Application
    Filed: October 30, 2015
    Publication date: November 23, 2017
    Inventors: Barbara Savoldo, Gianpietro Dotti, Caroline Eva Arber Barth
  • TARGETING CD138 IN CANCER
    Publication number: 20160017048
    Abstract: Embodiments of the present disclosure concern therapeutic vectors and cells that target certain cancer cells but do not other cells having the same antigen. In specific embodiments, the methods and compositions of the disclosure concern cells having a CD138-specific chimeric antigen receptor whose expression is under the control of environment-specific regulation. In specific embodiments the environment is hypoxia. In some cases, the compositions comprise a suicide gene.
    Type: Application
    Filed: March 7, 2014
    Publication date: January 21, 2016
    Inventors: Gianpietro Dotti, Carlos A. Ramos, Barbara Savoldo