Abstract: The present invention provides methods of treating an autoimmune disorder comprising administering to the subject an effective amount of a molecule comprising molecules having multispecificity, such as wherein at least one of a first immunoglobulin fragment antigen binding region (Fab1) and at least one of a second immunoglobulin fragment antigen binding region (Fab2), wherein Fab1 is specific for Fc?RI or Fc?RIIa, and wherein Fab2 is specific for Fc?RIIb.

Abstract: The present invention provides compositions comprising molecules having multispecificity and method of their use.

Abstract: The present invention provides compositions comprising molecules having multispecificity and method of their use.

Abstract: Particular members of the multisubunit immune recognition receptor (MIRR) family of receptors, specifically, the B cell antigen receptor (BCR), the pre-B cell receptor (pre-BCR), the pro-B cell receptor (pro-BCR), Ig Fc receptors (FcR), and NK receptors, can be physically uncoupled from their associated transducers. The invention describes regulatory compounds and methods for mimicking such dissociation/destabilization for the purposes of receptor desensitization and for treatment of conditions in which receptor desensitization or alternatively, enhanced or prolonged receptor sensitization, is desirable. Compounds and methods for enhancing or prolonging receptor sensitization are also disclosed, as are methods for identifying regulatory compounds suitable for use in the present methods.

Abstract: The invention provides isolated regulatory immune cells as well as cell cultures and conditioned media derived therefrom. Also provided are methods of repressing B cell autoantibody production and/or secretion and methods of treating autoimmune disorders using regulatory immune cells or precursors thereto. Further provided are methods of diagnosing in a mammalian subject a defect in regulatory cell mediated repression of autoantibody secretion by B cells.