Abstract: Provided herein are engineered IL-15 (eIL-15) molecules and complexes containing engineered IL-15 molecules (eIL-15 complexes) and encoding polynucleotides. Also provided are compositions and articles of manufacture containing the conjugates, and methods for their administration to subjects to enhance immune response. In some embodiments, the eIL-15 molecules or complexes specifically bind the IL-2/15R??c, complex on the surface of cells. Also provided are methods and uses employing the provided eIL-15 molecules alone or in combination with other therapeutic agents or treatment regimens.

Abstract: Methods are provided for using antibodies and antibody fragments that bind one or more cysteinyl leukotrienes (cysLTs) for treatment of diseases, including inflammatory, respiratory and gastrointestinal diseases and conditions associated with aberrant levels of one or more cysLTs. Anti-cysLT antibodies and antigen-binding antibody fragments, and compositions containing such antibodies and antibody fragments, are also provided.

Abstract: Methods are provided for using antibodies that bind one or more cysteinyl leukotrienes (cysLTs) for treatment of diseases, including inflammatory diseases and asthma, associated with aberrant levels of one or more cysLTs. Anti-cysLT antibodies and antigen-binding antibody fragments, and compositions containing such antibodies and antibody fragments, are also provided.