Patents by Inventor Barclay Morrison

Barclay Morrison has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hyaluronidase for the prevention, treatment, reduction and/or abolishment of cerebral edema and intracranial pressure
    Patent number: 12042528
    Abstract: The current invention is a method of treating, preventing, reducing and/or abolishing edema and/or intracranial pressure in a subject by the administration of hyaluronidase. The edema in the brain and intracranial pressure can be the result of a traumatic event, disease or condition including but not limited to a traumatic brain injury, a stroke, a brain tumor, and post-operative swelling.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: July 23, 2024
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Barclay Morrison, III, Steve Kernie, Patricia Walker
  • Systems and methods for real-time concussion diagnosis by electroencephalogram activity monitoring
    Patent number: 11759147
    Abstract: Systems and methods for detecting concussions in real-time are provided. An exemplary system of detecting concussions in real time includes an accelerometer to measure acceleration event and generate an accelerometry signal. The system includes a plurality of electrodes to detect an electroencephalogram (EEG) and each of the electrodes can be attached to a top region of the headgear through a flexible shaft. The system further includes a signal processing circuit to amplify, filter and broadcast an electroencephalogram (EEG) signal to a local wireless receiving unit.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: September 19, 2023
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: James M. Noble, Barclay Morrison, Catherine Schevon, Ioannis Kymissis
  • HYALURONIDASE FOR THE PREVENTION, TREATMENT, REDUCTION AND/OR ABOLISHMENT OF CEREBRAL EDEMA AND INTRACRANIAL PRESSURE
    Publication number: 20210369819
    Abstract: The current invention is a method of treating, preventing, reducing and/or abolishing edema and/or intracranial pressure in a subject by the administration of hyaluronidase. The edema in the brain and intracranial pressure can be the result of a traumatic event, disease or condition including but not limited to a traumatic brain injury, a stroke, a brain tumor, and post-operative swelling.
    Type: Application
    Filed: November 28, 2018
    Publication date: December 2, 2021
    Inventors: Barclay Morrison III, Steve Kernie, Patricia Walker
  • SYSTEMS AND METHODS FOR REAL-TIME CONCUSSION DIAGNOSIS BY ELECTROENCEPHALOGRAM ACTIVITY MONITORING
    Publication number: 20190298262
    Abstract: Systems and methods for detecting concussions in real-time are provided. An exemplary system of detecting concussions in real time includes an accelerometer to measure acceleration event and generate an accelerometry signal. The system includes a plurality of electrodes to detect an electroencephalogram (EEG) and each of the electrodes can be attached to a top region of the headgear through a flexible shaft. The system further includes a signal processing circuit to amplify, filter and broadcast an electroencephalogram (EEG) signal to a local wireless receiving unit.
    Type: Application
    Filed: June 8, 2017
    Publication date: October 3, 2019
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: James N. Noble, Barclay Morrison, Catherine Schevon, Ioannis Kymissis
  • Enzyme combinations to reduce brain tissue swelling
    Patent number: 9040040
    Abstract: Tissue fixed charge density (FCD) is identified as another potential therapeutic target for reducing brain tissue swelling. Reduction of the FCD could reduce the thermodynamic force driving water entry into the brain. The present invention discloses chondroitinase ABC (ChABC) reduces tissue FCD and reduces tissue swelling, indicating that it may be an effective treatment to reduce edema and control intracranial pressure.
    Type: Grant
    Filed: May 23, 2013
    Date of Patent: May 26, 2015
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Benjamin Simon Elkin, Barclay Morrison, III, John Desmond Finan
  • ENZYME COMBINATIONS TO REDUCE BRAIN TISSUE SWELLING
    Publication number: 20130259848
    Abstract: Tissue fixed charge density (FCD) is identified as another potential therapeutic target for reducing brain tissue swelling. Reduction of the FCD could reduce the thermodynamic force driving water entry into the brain. The present invention discloses chondroitinase ABC (ChABC) reduces tissue FCD and reduces tissue swelling, indicating that it may be an effective treatment to reduce edema and control intracranial pressure.
    Type: Application
    Filed: May 23, 2013
    Publication date: October 3, 2013
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Benjamin Simon ELKIN, Barclay MORRISON, III, John Desmond Finan
  • Spermidine derivatives for the treatment of chronic neurodegenerative diseases
    Publication number: 20050124554
    Abstract: Compounds of the general formula (I): are useful in treating chronic neurodegenerative diseases or conditions in mammals, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Chorea and Multiple Sclerosis. In formula (I), a=3 or 4; b=3 or 4 provided that a+b?7; c is an integer from 1 to 5; d is 0 or 1.
    Type: Application
    Filed: February 3, 2003
    Publication date: June 9, 2005
    Inventors: Barclay Morrison, Ashley Pringle, Lars Sundstrom, Ernst Wulfert