Patents by Inventor Barnett Rosenberg
Barnett Rosenberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8257714Abstract: The present invention provides compositions and methods for the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases, for stimulating an immune response in a subject, and for use as an alternative to interleukin-12 (IL-12) treatment. In particular, the present invention provides Apicomplexa-related proteins (ARPs) that have immune stimulatory activity and thus have uses in the treatment and prevention of cancer and infectious diseases and in immune modulation. Compositions comprising an ARP are provided. Methods of use of an ARP for the prevention and/or treatment of cancer and/or infectious diseases, for use as an alternative to interleukin-12 (IL-12) treatment, and for eliciting an immune response in a subject, are also provided.Type: GrantFiled: April 14, 2008Date of Patent: September 4, 2012Assignee: Michigan State UniversityInventors: Charles Aylsworth, Siu-Cheong Ho, David Juckett, John W. Judge, Barnett Rosenberg, Igor V. Zlatkin, Tatiana Zlatkin
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Methods of treating or preventing a disease, disorder or condition associated with a viral infection
Patent number: 7550150Abstract: The present invention relates to methods of treating or preventing a disease, disorder or condition associated with a viral infection using a dosing and resting regimen for administering a pharmaceutical composition that provides ARP.Type: GrantFiled: March 14, 2006Date of Patent: June 23, 2009Assignee: Barros Research InstituteInventors: Barnett Rosenberg, John W. Judge -
Publication number: 20090136999Abstract: The present invention provides compositions and methods for the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases, for stimulating an immune response in a subject, and for use as an alternative to interleukin-12 (IL-12) treatment. In particular, the present invention provides Apicomplexa-related proteins (ARPs) that have immune stimulatory activity and thus have uses in the treatment and prevention of cancer and infectious diseases and in immune modulation. Compositions comprising an ARP are provided. Methods of use of an ARP for the prevention and/or treatment of cancer and/or infectious diseases, for use as an alternative to interleukin-12 (IL-12) treatment, and for eliciting an immune response in a subject, are also provided.Type: ApplicationFiled: April 14, 2008Publication date: May 28, 2009Applicants: Michigan State University, Barros Research InstituteInventors: Charles Aylsworth, Siu-Cheong Ho, David Juckett, John W. Judge, Barnett Rosenberg, Igor V. Zlatkin, Tatiana Zlatkin
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Methods of treating or preventing a disease, disorder or condition associated with a viral infection
Publication number: 20060211027Abstract: The present invention relates to methods of treating or preventing a disease, disorder or condition associated with a viral infection using a dosing and resting regimen for administering a pharmaceutical composition that provides ARP.Type: ApplicationFiled: March 14, 2006Publication date: September 21, 2006Applicant: Barros Research InstituteInventors: Barnett Rosenberg, John Judge -
Publication number: 20050169935Abstract: The present invention provides compositions and methods for the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases, for stimulating an immune response in a subject, and for use as an alternative to interleukin-12 (IL-12) treatment. In particular, the present invention provides Apicomlexa-related proteins (ARPs) that have immune stimulatory activity and thus have uses in the treatment and prevention of cancer and infectious diseases and in immune modulation. Compositions comprising an ARP are provided. Methods of use of an ARP for the prevention and/or treatment of cancer and/or infectious diseases, for use as an alternative to interleukin-12 (IL-12) treatment, and for eliciting an immune response in a subject, are also provided.Type: ApplicationFiled: July 15, 2004Publication date: August 4, 2005Inventors: Charles Aylsworth, Siu-Cheong Ho, David Juckett, John Judge, Barnett Rosenberg, Igor Zlatkin, Tatiana Zlatkin
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Publication number: 20050058658Abstract: The present invention provides compositions and methods for the prevention and treatment of an infectious disease caused by infection with HIV and for stimulating an immune response in a subject. In particular, the present invention provides Apicomlexa-related proteins (ARPs) that have immune stimulatory activity and thus have uses in the treatment and prevention of an infectious disease caused by infection with HIV and in immune modulation. Compositions comprising an ARP are provided. Methods of use of an ARP for the prevention and/or treatment of an infectious disease caused with infection with HIV, and for eliciting an immune response in a subject, are also provided.Type: ApplicationFiled: July 15, 2004Publication date: March 17, 2005Applicant: Barros Research InstituteInventor: Barnett Rosenberg
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Patent number: 5562925Abstract: Malignant tumors in animals are treated by parenterally administering to an affected animal a solution containing a complex compound of platinum in an amount effective to cause regression of the tumor.Type: GrantFiled: June 2, 1994Date of Patent: October 8, 1996Assignee: Research Corporation Tech. Inc.Inventors: Barnett Rosenberg, Loretta Vancamp, Thomas Krigas
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Patent number: 5522974Abstract: Described is a method of preparing polyacrylamide gel containing capillary tube wherein acrylamide is polymerized from a liquid to a gel within the tube, the improvement comprising the steps of: a) after the polymerization, annealing the gel inside the tube by cycling the gel/tube at least once in a temperature range from 20.degree. C. to a temperature not to exceed about 75.degree. C. and back to ambient; and b) recovering the stress released gel-filled tube. Preferably, the polymerization commences at the middle of the tube and commences toward the extremities of the tube.Type: GrantFiled: October 21, 1993Date of Patent: June 4, 1996Assignee: Laurence A. FishelInventors: Laurence A. Fishel, Barnett Rosenberg, David A. Juckett
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Patent number: 4665069Abstract: An analgesia composition comprising an aqueous solution of a neurologically active agent in a concentration of from about 10.sup.-3 to about 10.sup.-13 grams/ml and a method of relieving pain comprising topically applying the composition to the genitalia of a human or non-human animal.Type: GrantFiled: April 2, 1985Date of Patent: May 12, 1987Inventor: Barnett Rosenberg
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Patent number: 4657927Abstract: Malonato platinum coordination compounds and a method of treating malignant tumors sensitive to a planar dsp.sup.2 platinum (II) coordination compound or an octahedral d.sup.2 sp.sup.3 platinum (IV) coordination compound comprising the parenteral administration to an affected animal of a solution of the compound.Type: GrantFiled: May 25, 1983Date of Patent: April 14, 1987Assignee: Research CorporationInventors: Michael J. Cleare, James D. Hoeschele, Barnett Rosenberg, Loretta Van Camp
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Patent number: 4584316Abstract: Palladium complexes and pharmaceutical compositions containing palladium complexes adapted for the treatment of tumors cells sensitive to the palladium complexes and methods of treating tumor cells using the palladium complexes are disclosed.Type: GrantFiled: July 16, 1984Date of Patent: April 22, 1986Assignee: Research CorporationInventors: Barnett Rosenberg, Devinder S. Gill
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Patent number: 4440782Abstract: A method for treating animals afflicted with a viral infection comprising the administration to the animal of a platinum coordination compound.Type: GrantFiled: September 18, 1980Date of Patent: April 3, 1984Assignee: Research CorporationInventors: James P. Davidson, Barnett Rosenberg, Ronald W. Hinz
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Patent number: 4419351Abstract: A platinum-[2,4-dioxopyrimidine] complex and pharmaceutical composition suitable as an anti-tumor, anti-bacterial and anti-viral agent and process for the manufacture thereof comprising reacting a 2,4-dioxopyrimidine having the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are suitable substituents with cis-diaquodiamineplatinum (II).Type: GrantFiled: December 18, 1978Date of Patent: December 6, 1983Assignee: Research CorporationInventors: Barnett Rosenberg, Loretta Van Camp, Robert G. Ficher, Samir Kansy, Henry J. Peresie, James P. Davidson
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Patent number: 4344440Abstract: A portable microprobe uses 10 gigahertz CW microwave radiation at a power level of less than 10 milliwatts for recording of a number of biophysical phenomena associated with the cardiac and neural activity of the life system. The microprobe consists of a Gunn diode feeding power into a short, insulated dielectric waveguide, the free end of which houses a point contact semiconductor diode isolated by a metal shield from the incident beam. The wave guide concentrates and delivers a pencil shaped beam into the tissue of interest and the back-scattered radiation is modulated and detected by the diode. The detected signal is filtered, amplified and recorded to reflect on-going biological activity. The receiver electronics is housed in a small self-contained package and has its output connected through a flexible attachment to two ear tubes which enable continuous monitoring of the audio response through an electrical and audio converter indicative of the on-going biological activity.Type: GrantFiled: April 1, 1980Date of Patent: August 17, 1982Inventors: Trygve Aaby, Barnett Rosenberg
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Patent number: 4339437Abstract: Malignant tumor cells sensitive to platinum coordination compounds in animals are treated by parenterally administering to an affected animal a solution containing a complex compound of platinum in an amount effective to cause regression of the tumor.Type: GrantFiled: July 26, 1979Date of Patent: July 13, 1982Assignee: Research CorporationInventors: Barnett Rosenberg, Loretta VanCamp, Thomas Krigas
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Patent number: 4258051Abstract: A method for treating animals afflicted with a viral infection comprising the administration to the animal of a platinum coordination compound.Type: GrantFiled: March 1, 1977Date of Patent: March 24, 1981Assignee: Research CorporationInventors: James P. Davidson, Barnett Rosenberg, Ronald W. Hinz
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Patent number: 4177263Abstract: Malignant tumors in animals are treated by parenterally administering to an affected animal a solution containing a complex compound of platinum in an amount effective to cause regression of the tumor.Type: GrantFiled: December 27, 1976Date of Patent: December 4, 1979Assignee: Research CorporationInventors: Barnett Rosenberg, Loretta VanCamp, Thomas Krigas
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Patent number: 4140707Abstract: Malonato platinum coordination compounds and a method of treating malignant tumors comprising the parenteral administration to an affected animal of a solution of the compound.Type: GrantFiled: March 18, 1977Date of Patent: February 20, 1979Assignee: Research CorporationInventors: Michael J. Cleare, James D. Hoeschele, Barnett Rosenberg, Loretta L. Van Camp
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Patent number: 4053587Abstract: A method for treating animals afflicted with a viral infection comprising the administration to the animal of a platinum coordination compound.This is a Continuation, of application Ser. No. 350,924, filed Apr. 13, 1973, now abandoned.Type: GrantFiled: January 10, 1975Date of Patent: October 11, 1977Assignee: Research CorporationInventors: James P. Davidson, Barnett Rosenberg, Ronald W. Hinz