Patents by Inventor Barrie E. Kirk

Barrie E. Kirk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Imidazole derivatives, pharmaceutical compositions and use
    Patent number: 5112819
    Abstract: Certain novel imidazole derivatives N-substituted by a vinyl group itself carrying a mevalonic acid derivative or corresponding lactone are inhibitors of HMG-CoA reductase and are useful for lowering blood plasma cholesterol levels.The compounds are of general formula (I): ##STR1## in which one of the groups R.sup.1 and R.sup.2 represents a C.sub.1-6 alkyl group optionally substituted by one to three halogen atoms and the other represents a phenyl ring optionally substituted by one to five substituents selected from halogen atoms and hydroxyl, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, S(O).sub.n C.sub.1-3 alkyl, (CH.sub.2).sub.m NR.sup.a R.sup.b, (CH.sub.2).sub.m NR.sup.c COR.sup.d and trifluoromethyl groups;R.sup.3 represents a phenyl ring optionally substituted by one to five substituents selected from halogen atoms and hydroxyl, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, S(O).sub.n C.sub.1-3 alkyl, (CH.sub.2).sub.m NR.sup.a R.sup.b, (CH.sub.2).sub.m NR.sup.c COR.sup.
    Type: Grant
    Filed: October 9, 1990
    Date of Patent: May 12, 1992
    Assignee: Glaxo Group Limited
    Inventors: Barry C. Ross, Barrie E. Kirk, Michael G. Lester, Panayiotis A. Procopiou, Nigel S. Watson
  • Carbocyclic analogues of 7H-1,2,3-triazolo [4,5-d]pyrimidine furanosides
    Patent number: 5100896
    Abstract: The present invention provides a compound of formula (I) ##STR1## and salts and solvates and pharmaceutically acceptable derivatives thereof, and describes processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of viral diseases, especially those caused by the Herpetoviridae.
    Type: Grant
    Filed: July 23, 1990
    Date of Patent: March 31, 1992
    Assignee: Glaxo Group Limited
    Inventors: Alan D. Borthwick, Keith Biggadike, Barrie E. Kirk, Richard Storer, Niall G. Weir, Anthony D. Baxter, Chi L. Mo
  • Guanine derivatives
    Patent number: 4857531
    Abstract: The present invention provides a compound of formula (I) ##STR1## and salts and solvates thereof, and describes processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of viral diseases, especially those caused by the Herpetoviridae.
    Type: Grant
    Filed: August 15, 1986
    Date of Patent: August 15, 1989
    Assignee: Glaxo Group Limited
    Inventors: David A. Borthwick, Barrie E. Kirk, Derek N. Evans, Keith Biggadike, Leslie Stephenson