Patents by Inventor Barry Berkowitz

Barry Berkowitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for controlling gram negative bacteria in mammals
    Patent number: 6017950
    Abstract: Methods for controlling growth of gram negative bacteria, such as Helicobacter pylori, which are agents associated with disorders of the gastrointestinal tract of a mammal are described. They include administering a therapeutically effective amount of a polyether ionophore antibiotic to a mammal, such that growth of gram negative bacteria which are agents associated with disorders of the gastrointestinal tract of a mammal is controlled. Packaged pharmaceutical compositions for controlling gram negative bacteria are also described.
    Type: Grant
    Filed: August 5, 1997
    Date of Patent: January 25, 2000
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Barry Berkowitz, George Sachs, Chris Blackburn
  • Peptide compositions and uses therefor
    Patent number: 5459237
    Abstract: A biologically active amphiphilic peptide which in accordance with an aspect of the present invention, includes one of the following basic structures X.sub.1 through X.sub.7, wherein:X.sub.1 is --[R.sub.1 --R.sub.2 --R.sub.2 --R.sub.3 --R.sub.1 --R.sub.2 --R.sub.2 ]--.sub.nX.sub.2 is --[R.sub.2 --R.sub.2 --R.sub.3 --R.sub.1 --R.sub.2 --R.sub.2 --R.sub.1 ]--.sub.n ;X.sub.3 is --[R.sub.2 --R.sub.3 --R.sub.1 --R.sub.2 --R.sub.2 --R.sub.1 --R.sub.2 ]--.sub.n ;X.sub.4 is --[R.sub.3 --R.sub.1 --R.sub.2 --R.sub.2 --R.sub.1 --R.sub.2 --R.sub.2 ]--.sub.n ;X.sub.5 is --[R.sub.1 --R.sub.2 --R.sub.2 --R.sub.1 --R.sub.2 --R.sub.2 --R.sub.3 ]--.sub.n ;X.sub.6 is --[R.sub.2 --R.sub.2 --R.sub.1 --R.sub.2 --R.sub.2 --R.sub.3 --R.sub.1 ]--.sub.n ; andX.sub.7 is --[R.sub.2 --R.sub.1 --R.sub.2 --R.sub.2 --R.sub.3 --R.sub.1 --R.sub.2 ]--.sub.n ;wherein R.sub.1 is a basic hydrophilic amino acid, R.sub.2 is a hydrophobic amino acid, R.sub.3 is a neutral hydrophilic, basic hydrophilic or hydrophobic amino acid and n is from 2 to 5.
    Type: Grant
    Filed: July 2, 1992
    Date of Patent: October 17, 1995
    Assignee: Magainin Pharmaceuticals Inc.
    Inventors: Barry Berkowitz, W. Lee Maloy, U. Prasad Kari
  • Composition and treatment with biologically active peptides and antibiotic
    Patent number: 5254535
    Abstract: A composition comprising at least one biologically active amphiphilic peptide, said peptide being an ion channel-forming peptide, and an antibiotic selected from the class consiting of bacitracins, aminoglycosides, penicillins, monobactams, hydrophobic antibiotics, 50-S ribosome inhibitors, antibiotics having a large lipid like lactone ring, and derivatives or analogues thereof. The biologically active amphiphilic peptide and the antibiotic may be administered in amounts effective to inhibit growth of a target cell. The biologically active amphiphilic peptide and antibiotic may potentiate each other.
    Type: Grant
    Filed: September 5, 1989
    Date of Patent: October 19, 1993
    Assignee: The Children's Hospital of Pennsylvania
    Inventors: Michael Zasloff, Barry Berkowitz
  • Composition and treatment with biologically active peptides and toxic cations
    Patent number: 5221664
    Abstract: A composition comprising a biologically active amphiphilic ion channel-forming peptide or ion channel forming protein and a toxic cation, such as a silver cation. Such compositions may be employed as pharmaceuticals, particularly for the treatment and prevention of eye infections.
    Type: Grant
    Filed: November 18, 1991
    Date of Patent: June 22, 1993
    Assignee: Magainin Pharmaaceuticals Inc.
    Inventors: Barry Berkowitz, Leonard Jacob
  • Composition and treatment with biologically active peptides and antibiotics which inhibit DNA gyrase
    Patent number: 5208220
    Abstract: A composition comprising at least one biologically active amphiphilic peptide or protein, said peptide or protein being an ion channel-forming peptide or protein, and an antibiotic which inhibits DNA gyrase. The biologically active amphiphilic peptide and the antibiotic which inhibits DNA gyrase may be administered in amounts effective to inhibit growth of a target cell such as a bacterium.
    Type: Grant
    Filed: November 15, 1991
    Date of Patent: May 4, 1993
    Assignee: Magainin Pharmaceuticals, Inc.
    Inventor: Barry Berkowitz
  • Wound treatment employing biologically active ion channel forming peptides and proteins
    Patent number: 5045531
    Abstract: A process for treating a wound in a host which comprises administering to the host having a wound at least one biologically active amphiphilic peptide. The peptide is an ion channel-forming peptide and is administered in an amount effective for treating a wound in a host.
    Type: Grant
    Filed: December 18, 1989
    Date of Patent: September 3, 1991
    Assignee: Magainin Sciences Inc.
    Inventors: Barry Berkowitz, Leonard S. Jacob
  • Wound treatment employing biologically active ion channel forming peptides and proteins
    Patent number: RE35492
    Abstract: A process for treating a wound in a host which comprises administering to the host having a wound at least one biologically active amphiphilic peptide. The peptide is an ion channel-forming peptide and is administered in an amount effective for treating a wound in a host.
    Type: Grant
    Filed: September 8, 1994
    Date of Patent: April 8, 1997
    Assignee: Magainin Pharmaceuticals, Inc.
    Inventors: Barry Berkowitz, Leonard S. Jacob