Patents by Inventor Barry Bratcher
Barry Bratcher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10822591Abstract: Disclosed herein are methods and exemplary compositions associated with virus purification, exemplary aspects of which may include harvesting viral and antigenic substances from source organisms; and a purification platform comprising chemical separation and size-difference separation for the removal of contaminants, debris and impurities from the viral and protein (e.g. antigenic, including influenza hemagglutinin antigens) substances, as well as their concentration and collection.Type: GrantFiled: June 11, 2019Date of Patent: November 3, 2020Assignee: KENTUCKY BIOPROCESSING, INC.Inventors: Leigh Burden, Steven D. Hume, Joshua Morton, Greg Pogue, Barry Bratcher, Hugh A. Haydon, Carrie A. Simpson, Nick Partain, John W. Shepherd
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Patent number: 10757964Abstract: The disclosure describes methods for the purification of protein-enriched extracts to provide concentrates and isolates and methods for incorporation of such materials into products. The purification methods are adapted for removal of nicotine and may have other benefits, e.g., lightening the color of the protein-enriched extracts. The methods generally include treatment with peracetic acid or hydrogen peroxide and filtrations. A protein composition in the form of a concentrate or isolate is provided, the protein composition including RuBisCO, F2 fraction proteins, or combination thereof extracted from a plant of the Nicotiana species, wherein the protein composition is characterized by relatively low nicotine content.Type: GrantFiled: July 20, 2017Date of Patent: September 1, 2020Assignee: R.J. Reynolds Tobacco CompanyInventors: Kyle Ford, John-Paul Mua, Nicholas Partain, Joshua D. Morton, Barry Bratcher
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Publication number: 20200229461Abstract: The disclosure describes methods for the purification of protein-enriched extracts to provide concentrates and isolates and methods for incorporation of such materials into products. The purification methods are adapted for removal of, e.g., chlorophyll and may thus provide lightening the color of the protein-enriched extracts. The methods generally include treatment with peracetic acid or hydrogen peroxide and filtrations. A protein composition in the form of a concentrate or isolate is provided, the protein composition including RuBisCO, F2 fraction proteins, or combination thereof extracted from a plant material.Type: ApplicationFiled: January 16, 2020Publication date: July 23, 2020Inventors: Nicholas Partain, Joshua D. Morton, Barry Bratcher, John-Paul Mua, Kyle Ford
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Publication number: 20200113999Abstract: Disclosed herein are methods of forming compounds and exemplary compounds in the nature of a conjugated compound demonstrating enhanced stability, which in some embodiments comprises a protein and virus particle mixed in a conjugation reaction to form a conjugate mixture, such that the conditions and steps of forming these products allow for unrefrigerated storage for longer time periods than previous approaches, thus making feasible access to such products over a global supply chain.Type: ApplicationFiled: December 10, 2019Publication date: April 16, 2020Inventors: Leigh Burden, Steven D. Hume, Joshua Morton, Greg Pogue, Barry Bratcher, Hugh A. Haydon, Carrie A. Simpson, Nick Partain
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Publication number: 20190380378Abstract: The disclosure describes methods for providing nicotine isolates, including: receiving a solution containing nicotine derived from green tobacco biomass of a plant of the Nicotiana species; converting the nicotine to nicotine sulfate; concentrating the resulting nicotine sulfate-containing solution; adjusting the pH of the resulting nicotine sulfate concentrate to a pH of about 9.5 or greater to convert the nicotine sulfate to nicotine in free base form; extracting the resulting basic concentrate with an organic solvent to partition the nicotine into the organic solvent; and distilling the nicotine-containing organic solution to afford a nicotine isolate comprising about 90% or more nicotine by weight.Type: ApplicationFiled: June 13, 2019Publication date: December 19, 2019Inventors: Nicholas Partain, Joshua D. Morton, Carrie A. Simpson, Gary M. Dull, Barry Bratcher
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Publication number: 20190376049Abstract: Disclosed herein are methods and exemplary compositions associated with virus purification, antigen purification, and conjugation of virus and proteins (e.g., antigen) to form vaccines for delivery of immunological and other therapeutic agents, exemplary aspects of which may include harvesting viral and antigenic substances from source organisms; a purification platform comprising chemical separation and size-difference separation for the removal of contaminants, debris and impurities from the viral and protein (e.g. antigenic, including influenza hemagglutinin antigens) substances, as well as their concentration and collection; and a conjugation platform providing activation of the virus at a pH that increases binding rate and binding propensity between the virus and the protein, wherein embodiments related to the conjugation platform include controlling the ratio of virus to protein.Type: ApplicationFiled: June 11, 2019Publication date: December 12, 2019Inventors: Leigh Burden, Steven D. Hume, Joshua Morton, Greg Pogue, Barry Bratcher, Hugh A. Haydon, Carrie A. Simpson, Nick Partain
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Publication number: 20190374616Abstract: Disclosed herein are methods and exemplary compositions associated with virus purification, antigen purification, and conjugation of virus and proteins (e.g., antigen) to form vaccines for delivery of immunological and other therapeutic agents, exemplary aspects of which may include harvesting viral and antigenic substances from source organisms; a purification platform comprising chemical separation and size-difference separation for the removal of contaminants, debris and impurities from the viral and protein (e.g. antigenic, including influenza hemagglutinin antigens) substances, as well as their concentration and collection; and a conjugation platform providing activation of the virus at a pH that increases binding rate and binding propensity between the virus and the protein, wherein embodiments related to the conjugation platform include controlling the ratio of virus to protein.Type: ApplicationFiled: June 11, 2019Publication date: December 12, 2019Inventors: Leigh Burden, Steven D. Hume, Joshua Morton, Greg Pogue, Barry Bratcher, Hugh A. Haydon, Carrie A. Simpson, Nick Partain
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Patent number: 10214747Abstract: A new platform method to purify plant-based monoclonal antibodies is provided. Such a method includes an antibody purification platform that involves a standardized procedure for the production of a wide array of different antibodies within a simplified context. The versatility of the overall purification process accords a one-size-fits-all approach for myriad antibody products and includes plant tissue harvesting, extraction and clarification, filtrate generation, a succession of column chromatography procedures, and buffer exposure to provide the desired monoclonal antibodies in proper filtered and purified form for further incorporation and/or use within medicaments and other formulations. Thus, the purified monoclonal antibodies produced thereby such a method are also encompassed within this invention.Type: GrantFiled: October 3, 2014Date of Patent: February 26, 2019Assignee: KENTUCKY BIOPROCESSING, INC.Inventors: Josh Morton, Barry Bratcher, Kelsi Swope, Emmett Ernest Hiatt, III, Steven D. Hume, Larry Zeitlin
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Publication number: 20190021391Abstract: The disclosure describes methods for the purification of protein-enriched extracts to provide concentrates and isolates and methods for incorporation of such materials into products. The purification methods are adapted for removal of nicotine and may have other benefits, e.g., lightening the color of the protein-enriched extracts. The methods generally include treatment with peracetic acid or hydrogen peroxide and filtrations. A protein composition in the form of a concentrate or isolate is provided, the protein composition including RuBisCO, F2 fraction proteins, or combination thereof extracted from a plant of the Nicotiana species, wherein the protein composition is characterized by relatively low nicotine content.Type: ApplicationFiled: May 11, 2018Publication date: January 24, 2019Inventors: Kyle Ford, John-Paul Mua, Nicholas Partain, Joshua D. Morton, Barry Bratcher
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Publication number: 20190021390Abstract: The disclosure describes methods for the purification of protein-enriched extracts to provide concentrates and isolates and methods for incorporation of such materials into products. The purification methods are adapted for removal of nicotine and may have other benefits, e.g., lightening the color of the protein-enriched extracts. The methods generally include treatment with peracetic acid or hydrogen peroxide and filtrations. A protein composition in the form of a concentrate or isolate is provided, the protein composition including RuBisCO, F2 fraction proteins, or combination thereof extracted from a plant of the Nicotiana species, wherein the protein composition is characterized by relatively low nicotine content.Type: ApplicationFiled: July 20, 2017Publication date: January 24, 2019Inventors: Kyle Ford, John-Paul Mua, Nicholas Partain, Joshua D. Morton, Barry Bratcher
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Publication number: 20180263276Abstract: The present disclosure describes methods of obtaining and/or deriving proteins from plants of the Nicotiana species and methods for incorporation of such proteins into various products. For example, a method for obtaining a protein-enriched material from a plant of the Nicotiana species or portion thereof is provided, comprising: extracting one or more proteins from the plant material into a solvent to form a liquid protein-containing extract; separating a solid extracted plant material from the liquid protein-containing extract; clarifying the liquid protein-containing extract to form a clarified protein-containing extract and a solids fraction; and treating the clarified protein-containing extract so as to provide a protein-enriched material comprising at least about 60% protein by weight.Type: ApplicationFiled: May 24, 2018Publication date: September 20, 2018Inventors: John-Paul Mua, Kyle Ford, Leigh Ann Blevins Joyce, Margarette Elisa Lovette, Joshua D. Morton, Leigh Hagan, Barry Bratcher, Samuel Mark Debusk
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Patent number: 9775376Abstract: A smokeless tobacco composition configured for insertion into the mouth of a user is provided. The smokeless tobacco composition includes a tobacco material, a sugar alcohol, and a natural gum binder component, wherein the composition is in the form of a pastille. A process for preparing a smokeless tobacco composition pastille configured for insertion into the mouth of a user is also provided. The process includes providing an aqueous mixture comprising a hydrated natural gum binder component, mixing a tobacco material with the aqueous mixture to form a smokeless tobacco mixture, heating the smokeless tobacco mixture, depositing the heated smokeless tobacco mixture into a mold, and curing the smokeless tobacco mixture to form a smokeless tobacco composition pastille.Type: GrantFiled: December 1, 2010Date of Patent: October 3, 2017Assignee: R.J. Reynolds Tobacco CompanyInventors: Daniel Verdin Cantrell, Joshua D. Morton, Steven D. Hume, Barry Bratcher, Robert Frank Boutin, Thomas Hinkemeyer, Thaddeus J. Jackson
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Patent number: 9661876Abstract: The present disclosure describes methods of obtaining and/or deriving a sugar-enriched extract from plants of the Nicotiana species and methods for incorporation of such extracts into various tobacco compositions. One exemplary method for preparing a sugar-enriched extract comprises contacting Nicotiana plant material with a solvent and extracting sugars into the solvent to form a liquid sugar-containing extract; separating a solid extracted plant material from the liquid sugar-containing extract; clarifying the liquid sugar-containing extract to form a clarified sugar-containing extract and a solids fraction; and isolating the liquid sugar-containing extract to provide a sugar-enriched extract comprising a combined weight of fructose and glucose of at least about 10% by dry weight. In certain embodiments, the sugars of the extract comprise at least about 50% by weight fructose.Type: GrantFiled: March 14, 2013Date of Patent: May 30, 2017Assignee: R.J. Reynolds Tobacco CompanyInventors: John-Paul Mua, Barry Bratcher, Kyle Ford, Leigh Hagan, Leigh Ann Blevins Joyce, Joshua D. Morton, Samuel Mark Debusk, Margarette Elisa Lovette
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Publication number: 20160333365Abstract: A new platform method to purify plant-based monoclonal antibodies is provided. Such a method includes an antibody purification platform that involves a standardized procedure for the production of a wide array of different antibodies within a simplified context. The versatility of the overall purification process accords a one-size-fits-all approach for myriad antibody products and includes plant tissue harvesting, extraction and clarification, filtrate generation, a succession of column chromatography procedures, and buffer exposure to provide the desired monoclonal antibodies in proper filtered and purified form for further incorporation and/or use within medicaments and other formulations. Thus, the purified monoclonal antibodies produced thereby such a method are also encompassed within this invention.Type: ApplicationFiled: October 3, 2014Publication date: November 17, 2016Inventors: Josh Morton, Barry Bratcher, Kelsi Swope, Emmett Ernest Hiatt, III, Steven D. Hume, Larry Zeitlin
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Publication number: 20160192697Abstract: The present disclosure describes methods of obtaining and/or deriving proteins from plants of the Nicotiana species and methods for incorporation of such proteins into various products. For example, a method for obtaining a protein-enriched material from a plant of the Nicotiana species or portion thereof is provided, comprising: extracting one or more proteins from the plant material into a solvent to form a liquid protein-containing extract; separating a solid extracted plant material from the liquid protein-containing extract; clarifying the liquid protein-containing extract to form a clarified protein-containing extract and a solids fraction; and treating the clarified protein-containing extract so as to provide a protein-enriched material comprising at least about 60% protein by weight.Type: ApplicationFiled: March 14, 2016Publication date: July 7, 2016Inventors: John-Paul Mua, Kyle Ford, Leigh Ann Blevins Joyce, Margarette Elisa Lovette, Joshua D. Morton, Leigh Hagan, Barry Bratcher, Samuel Mark Debusk
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Patent number: 9301544Abstract: The present disclosure describes methods of obtaining and/or deriving proteins from plants of the Nicotiana species and methods for incorporation of such proteins into various products. For example, a method for obtaining a protein-enriched material from a plant of the Nicotiana species or portion thereof is provided, comprising: extracting one or more proteins from the plant material into a solvent to form a liquid protein-containing extract; separating a solid extracted plant material from the liquid protein-containing extract; clarifying the liquid protein-containing extract to form a clarified protein-containing extract and a solids fraction; and treating the clarified protein-containing extract so as to provide a protein-enriched material comprising at least about 60% protein by weight.Type: GrantFiled: March 14, 2013Date of Patent: April 5, 2016Assignee: R.J. Reynolds Tobacco CompanyInventors: John-Paul Mua, Kyle Ford, Leigh Ann Blevins Joyce, Margarette Elisa Lovette, Joshua D. Morton, Leigh Hagan, Barry Bratcher, Samuel Mark Debusk
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Patent number: 9220295Abstract: A process of extracting at least one target component from a plant material is provided. The process includes homogenizing a plant material in the presence of an extraction solvent to reduce the plant material to a plant liquid component and a plant pulp component. Each of the components may be further processed to extract specific components therefrom. Specifically, the plant liquid component can be processed to extract a plant-derived starch material, plant-derived proteins, plant-derived sugars, plant-derived sugars, and the like. The plant pulp material can be processed to extract pectin and cellulose. An associated system is also provided.Type: GrantFiled: March 25, 2011Date of Patent: December 29, 2015Assignee: R.J. Reynolds Tobacco CompanyInventors: Joshua D. Morton, Steven D. Hume, Barry Bratcher
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Publication number: 20140271952Abstract: The present disclosure describes methods of obtaining and/or deriving proteins from plants of the Nicotiana species and methods for incorporation of such proteins into various products. For example, a method for obtaining a protein-enriched material from a plant of the Nicotiana species or portion thereof is provided, comprising: extracting one or more proteins from the plant material into a solvent to form a liquid protein-containing extract; separating a solid extracted plant material from the liquid protein-containing extract; clarifying the liquid protein-containing extract to form a clarified protein-containing extract and a solids fraction; and treating the clarified protein-containing extract so as to provide a protein-enriched material comprising at least about 60% protein by weight.Type: ApplicationFiled: March 14, 2013Publication date: September 18, 2014Applicant: R.J. REYNOLDS TOBACCO COMPANYInventors: John-Paul Mua, Kyle Ford, Leigh Ann Blevins Joyce, Margarette Elisa Lovette, Joshua D. Morton, Leigh Hagan, Barry Bratcher, Samuel Mark Debusk
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Publication number: 20140271951Abstract: The present disclosure describes methods of obtaining and/or deriving a sugar-enriched extract from plants of the Nicotiana species and methods for incorporation of such extracts into various tobacco compositions. One exemplary method for preparing a sugar-enriched extract comprises contacting Nicotiana plant material with a solvent and extracting sugars into the solvent to form a liquid sugar-containing extract; separating a solid extracted plant material from the liquid sugar-containing extract; clarifying the liquid sugar-containing extract to form a clarified sugar-containing extract and a solids fraction; and isolating the liquid sugar-containing extract to provide a sugar-enriched extract comprising a combined weight of fructose and glucose of at least about 10% by dry weight. In certain embodiments, the sugars of the extract comprise at least about 50% by weight fructose.Type: ApplicationFiled: March 14, 2013Publication date: September 18, 2014Applicant: R.J. REYNOLDS TOBACCO COMPANYInventors: John-Paul Mua, Barry Bratcher, Kyle Ford, Leigh Hagan, Leigh Ann Blevins Joyce, Joshua D. Morton, Samuel Mark Debusk, Margarette Elisa Lovette
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Publication number: 20130263870Abstract: A smokeless tobacco composition configured for insertion into the mouth of a user is provided. The smokeless tobacco composition includes a tobacco material, a sugar alcohol, and a natural gum binder component, wherein the composition is in the form of a pastille. A process for preparing a smokeless tobacco composition pastille configured for insertion into the mouth of a user is also provided. The process includes providing an aqueous mixture comprising a hydrated natural gum binder component, mixing a tobacco material with the aqueous mixture to form a smokeless tobacco mixture, heating the smokeless tobacco mixture, depositing the heated smokeless tobacco mixture into a mould, and curing the smokeless tobacco mixture to form a smokeless tobacco composition pastille.Type: ApplicationFiled: May 31, 2013Publication date: October 10, 2013Inventors: Daniel Verdin Cantrell, Joshua D. Morton, Steven D. Hume, Barry Bratcher, Robert Frank Boutin, Thomas Hinkemeyer, Thaddeus J. Jackson