Abstract: A portable threat detection apparatus and method is disclosed which may comprise a plurality of acoustic emission sensors arranged in a cluster, forming a polygon defining at least two axes of alignment between respective pairs of acoustic emission sensors; a computing device in cooperation with a non-transitory computer readable storage medium comprising computer readable instructions for performing: receiving a first signal produced by a first acoustic emission sensor within a respective pair of acoustic emission sensors, in response to the first acoustic emission sensor detecting an acoustic emission from a source, and receiving a second signal produced by a second acoustic emission sensor within the respective pair of acoustic emission sensors, in response to the second acoustic emission sensor detecting the acoustic emission; determining a cross-correlation factor between the first signal and the second signal; and, determining a bearing to the source based on the cross correlation factor.

Abstract: A portable threat detection apparatus and method is disclosed which may comprise a plurality of acoustic emission sensors arranged in a cluster, forming a polygon defining at least two axes of alignment between respective pairs of acoustic emission sensors; a computing device in cooperation with a non-transitory computer readable storage medium comprising computer readable instructions for performing: receiving a first signal produced by a first acoustic emission sensor within a respective pair of acoustic emission sensors, in response to the first acoustic emission sensor detecting an acoustic emission from a source, and receiving a second signal produced by a second acoustic emission sensor within the respective pair of acoustic emission sensors, in response to the second acoustic emission sensor detecting the acoustic emission; determining a cross-correlation factor between the first signal and the second signal; and, determining a bearing to the source based on the cross correlation factor.

Abstract: Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsinlike activity of the 20S proteasome may be selectively inhibited with the inventive compounds. The peptide-based compounds include an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of cell proliferation.

Abstract: Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like activity of the 20S proteasome may be selectively inhibited with the inventive compounds. The peptide-based compounds include at least three peptide units, an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of cell proliferation.

Abstract: The present invention relates to novel N-cyanomethyl amides which are cysteine protease inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.

Abstract: Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like activity of the 20S proteasome may be selectively inhibited with the inventive compounds. The peptide-based compounds include at least three peptide units, an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of cell proliferation.