Abstract: The invention provides compounds of formula (I): ##STR1## or a physiologically acceptable salt, solvate or metabolically labile ester thereof wherein the R groups are defined in the specification.The compounds may be used in the treatment or prophylaxis of hypertension and diseases associated with cognitive disorders.

Abstract: The invention provides compounds of the general formula (I): ##STR1## or a physiologically acceptable salt, solvate (e.g. hydrate) or a metabolically labile ester thereof.The compounds may be used in the treatment or prophylaxis of hypertension and diseases associated with cognitive disorders.

Abstract: The invention provides compounds of the general formula (I) ##STR1## and physiologically acceptable salts, solvates or non-toxic metabolically labile esters thereof where R.sup.1 represents a halogen atom; Ar represents the group ##STR2## R.sup.3 represents a C-linked tetrazolyl group; R.sup.4 and R.sup.5, which may be the same or different, each independently represent a hydrogen atom or a halogen atom or a C.sub.1-6 alkyl group; andHet represents an N-linked imidazolyl group optionally substituted at the 2-position.The compounds may be used in the treatment or prophylaxis of hypertension and diseases associated with cognitive disorders.

Abstract: The invention provides compounds of formula (I): ##STR1## or a physiologically acceptable salt, solvate or metabolically labile ester thereof whereinR.sup.1 represents a hydrogen atom or a halogen atom or a group selected from C.sub.1-6 alkyl, C.sub.2-6 alkenyl, fluoroC.sub.1-6 alkyl, C.sub.1-6 alkoxy, --CHO, --CO.sub.2 H or --COR.sup.2 ;Ar represents optionally substituted phenylHet represents the group ##STR2## A represents ##STR3## The compounds may be used in the treatment or prophylaxis of hypertension and diseases associated with cognitive disorders.

Abstract: The invention provides compounds of formula (I): ##STR1## or a physiologically acceptable salt, solvate or metabolically labile ester thereof whereinR.sup.1 represents a hydrogen atom or a halogen atom or a group selected from C.sub.1-6 alkyl, C.sub.2-6 alkenyl, fluoroC.sub.1-6 alkyl, C.sub.1-6 alkoxy, --CHO, --CO.sub.2 H or --COR.sup.2 ;Ar represents the group ##STR2## Het represents an N-linked imidazolyl group optionally substituted by one, two or three substituents.The compounds may be used in the treatment or prophylaxis of hypertension and diseases associated with cognitive disorders.

Abstract: The invention provides compounds of formula (I): ##STR1## or a physiologically acceptable salt, solvate or metabolically labile ester thereof.The compounds may be used in the treatment or prophylaxis of hypertension and diseases associated with cognitive disorders.

Abstract: This invention relates to imidazole derivatives having hypocholesterolemic and hypolipidemic activity, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medicine, particularly in the treatment and/or prevention of atherosclerosis and coronary heart disease.

Abstract: Certain novel imidazole derivatives N-substituted by a vinyl group itself carrying a mevalonic acid derivative or corresponding lactone are inhibitors of HMG-CoA reductase and are useful for lowering blood plasma cholesterol levels.The compounds are of general formula (I): ##STR1## in which one of the groups R.sup.1 and R.sup.2 represents a C.sub.1-6 alkyl group optionally substituted by one to three halogen atoms and the other represents a phenyl ring optionally substituted by one to five substituents selected from halogen atoms and hydroxyl, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, S(O).sub.n C.sub.1-3 alkyl, (CH.sub.2).sub.m NR.sup.a R.sup.b, (CH.sub.2).sub.m NR.sup.c COR.sup.d and trifluoromethyl groups;R.sup.3 represents a phenyl ring optionally substituted by one to five substituents selected from halogen atoms and hydroxyl, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, S(O).sub.n C.sub.1-3 alkyl, (CH.sub.2).sub.m NR.sup.a R.sup.b, (CH.sub.2).sub.m NR.sup.c COR.sup.

Abstract: Compounds of formula ##STR1## wherein R.sup.1 or R.sup.2 represents a C.sub.1-6 alkyl group optionally substituted by one to three halogen atoms and the other represents a phenyl or pyridyl ring or N-oxide thereof optionally substituted by one or more substituents selected from halogen atoms and hydroxyl, C.sub.1-3 alkyl, C.sub.1-3 alkoxy and trifluoromethyl groups; wherein R.sup.3 represents a phenyl or pyridyl ring or N-oxide thereof optionally substituted by one or more substituents selected from halogen atoms and hydroxyl, C.sub.1-3 alkyl, C.sub.1-3 alkoxy and trifluoromethyl groups with the proviso that only one of the groups R.sup.1, R.sup.2 or R.sup.3 represents an optionally substituted pyridyl ring; X represents --CH.dbd.CH--; and Z represents ##STR2## wherein R.sup.4 represents a hydrogen atom, a carboxyl protecting group or a cation; and R.sup.5 represents a hydrogen atom or a C.sub.1-3 alkyl group; a solvate thereof, or acid addition salts of compounds wherein R.sup.

Abstract: A compound of the formula I ##STR1## in which R.sup.1 represents a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms, the --CONHR.sup.1 group being present at the 3- or 4-position on the phenyl ring, and esters thereof at the 2-carboxyl group and/or at the 8-hydroxy group, have antibacterial and/or .beta.-lactamase inhibiting activity.

Abstract: Intermediate compounds of the formula ##STR1## for the preparation of antibacterially active penem compounds and salts wherein R is hydrogen or an esterifying group, R.sup.1 is an unsubstituted or a mono-, di-, or tri-substituted phenyl, naphthyl, thienyl, pyridyl, quinolyl or isoquinolyl, R.sup.2 is hydrogen or a hydroxyl group which may be protected, R.sup.4 is chlorine or bromine and R.sup.5 is an alkyl or phenyl group; methods for making such compounds or salts.

Abstract: The present invention relates to certain penem derivatives of the general formula I ##STR1## in which R represents a hydrogen atom or a carboxyl esterifying group, R.sup.1 represents certain unsubstituted and substituted aromatic and heterocyclic groups, and R.sup.2 represents a hydrogen atom, an unsubstituted or substituted alkyl or aryl group.The compound of formula I and salts thereof may be used in the treatment of bacterial infections in man and other animals.

Abstract: Penem-derivatives of the formula I ##STR1## in which R is hydrogen or a carboxyl esterifying groupR.sup.1 is phenyl, naphthyl, thienyl, pyridyl, quinolyl or isoquinolyl any of which is optionally substituted by one, two or three substituents of the group halogen, cycloalkyl, --NH.sub.2, --CONH.sub.2, --NO.sub.2, --CN, --R.sup.2, --OR.sup.2, --SR.sup.2, --SO--R.sup.2, --SO.sub.2 R.sup.2, --CO--R.sup.2, --CO--O--R.sup.2, --CH.sub.2 --CO--O--R.sup.2, --NHR.sup.2, --NR.sup.2 R.sup.2', --CO--NH--R.sup.2, --CO--NR.sup.2 R.sup.2', --NH--CO--R.sup.2, --NH--CO--NH--R.sub.2, --NH--CO--NH--R.sup.2, --NH--SO.sub.2 --R.sup.2, --CF.sub.3, --CO--OH, --CO.sub.2 --CO--OH wherein R.sup.2 and R.sup.2' are the same or different and each represents alkyl of 1 to 4 carbon atomsor a salts thereof, process for the manufacture thereof and antibacterial pharmaceutical preparations containing them.

Abstract: Compounds of the formula Ia and their tautomers Ib ##STR1## in which formulae R represents a carboxyl esterifying group are described, as well as processes for their manufacture. Ia and Ib are valuable starting materials for the preparation of various derivatives substituted at position 3 that possess antibacterial properties.

Abstract: BIS-Imido carbonate sulphones of the formula: ##STR1## in which R represents phenyl which is unsubstituted or substituted by one or two substituents, which is the same or different, selected from methyl, trifluoromethyl, nitro and cyano groups, and chlorine, flourine and bromine atoms, and p represents the integer 1, are produced by reacting a compound of formula VI ##STR2## in which R is as defined above, with thionyl chloride in the presence of an organic base. The compounds of formula II are useful in the production of 1, 2, 4, 6-thiatriazines.

Abstract: New thiazole derivatives of the general formula I ##STR1## and their salts with physiologically acceptable acids are described as well as a process for their manufacture. The new compounds exhibit histamine H-2 antagonist activity and may thus be used to inhibit gastric acid secretion and to treat gastric and peptic ulcers.

Abstract: Antibacterially active penem compounds and salts of the formula ##STR1## wherein R is hydrogen or an esterifying group, R.sup.2 is hydrogen, hydroxy, or protected hydroxy, and R.sup.1 is phenyl, naphthyl, thienyl, pyridyl, quinolyl, or isoquinolyl, or such a group which is mono-, di-, or tri-substituted; methods for making such compounds or salts; and antibacterial pharmaceutical preparations containing the compounds or salts.

Abstract: What are disclosed are penem compounds of the formula ##STR1## wherein R is hydrogen, a cation, or an esterifying group and R.sup.1 is alkyl or aryl, methods for making such compounds, methods for using the compounds as a .beta.-lactamase inhibitor or as an antibacterial agent, and pharmaceutical preparations containing the compounds.

Abstract: What are disclosed are compounds, useful as intermediates in the preparation of substituted penem compounds, of the formula ##STR1## wherein R is a removable esterifying group, R.sup.1 is lower alkyl or phenyl, R.sup.2 is hydrogen, lower alkyl, lower alkoxyalkyl, lower alkanoyloxyalkyl, or tri-lower alkylsilyloxyalkyl, and R.sub.a, R.sub.b, R.sub.c, R.sub.d, and R.sub.e are hydrogen, aliphatic cycloaliphatic hydrocarbon, free or esterified carboxyl, halo, or cyano, and any two of R.sub.a -R.sub.e, taken together, may form a cycloaliphatic ring.

Abstract: What are disclosed are compounds, useful as intermediates in the preparation of substituted penem compounds, of the formula ##STR1## wherein R is a removable esterifying group, R.sup.2 is hydrogen, lower alkyl, lower alkoxyalkyl, lower alkanoyloxyalkyl, or tri-lower alkylsilyloxyalkyl, and R.sub.a, R.sub.b, R.sub.c, R.sub.d, and R.sub.e are hydrogen, aliphatic cycloaliphatic hydrocarbon, free or esterified carboxyl, halo, or cyano, and any two of R.sub.a -R.sub.e, taken together, may form a cycloaliphatic ring.